Under Dr. Jenny Ting, Program Director, the Administrative Core supports the scientific and translational goals of this Center of Excellence for Immune Mechanisms of Virus Control (CEIMVC) by providing leadership and day-to-day operational administration. The Administrative Core is responsible for managing, coordinating, and supervising the overall project. It will coordinate administrative/scientific oversight of all research projects, cores, and pilot programs and the activities ofthe external Scientific Advisory Board (SAB). In addition, this Core is responsible for the day-to-day operations and management, including monitoring of expenditures, addressing grant management issues as well as unexpected issues that arise. The primary goal of the Administrative Core is to promote success for all Center programs by managing, coordinating, and supervising all Center activities. This includes research programs, core activities, pilot research projects, financial monitoring and oversight, compliance and regulatory activities, intellectual property and technology development, biosafety and security issues for all personnel, materials and data sharing plans associated with Center programs. The Administrative Core is ultimately responsible for ensuring the successful completion of the Center's mission to study novel immune mechanisms that are generalizable to anti-viral immunity. We will be assisting all personnel associated with the Program in achieving the goals listed in the Program Abstract, specifically in advancing knowledge regarding novel PRRs that are important for nucleic acid sensing and applying this knowledge to the study of NIAID high priority viral pathogens. The Scientific Administrators and the Administrative Staff will work together toward the stated goals.

Public Health Relevance

The administrative core for the Center of Excellence for Immune Mechanisms of Virus Control is crucial for the research program, regulatory activities, biosafety, security issues, and financial monitoring. Administrative Core is ultimately responsible for ensuring the successful completion ofthe Center's goal of unveiling how novel intracellular Pathogen Recognition Receptors mediate host response to NIAID high priority viruses.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Program--Cooperative Agreements (U19)
Project #
1U19AI109965-01
Application #
8675629
Study Section
Special Emphasis Panel (ZAI1-ZL-I (J1))
Project Start
Project End
Budget Start
2014-03-01
Budget End
2015-02-28
Support Year
1
Fiscal Year
2014
Total Cost
$182,413
Indirect Cost
$62,254
Name
University of North Carolina Chapel Hill
Department
Type
DUNS #
608195277
City
Chapel Hill
State
NC
Country
United States
Zip Code
27599
Feng, Zongdi; Li, You; McKnight, Kevin L et al. (2015) Human pDCs preferentially sense enveloped hepatitis A virions. J Clin Invest 125:169-76
Giguère, Patrick M; Gall, Bryan J; Ezekwe Jr, Ejiofor A D et al. (2014) G Protein signaling modulator-3 inhibits the inflammasome activity of NLRP3. J Biol Chem 289:33245-57
Damania, Blossom; Dittmer, Dirk P (2014) What lies within: coinfections and immunity. Cell Host Microbe 16:145-7
Zhang, Lu; Mo, Jinyao; Swanson, Karen V et al. (2014) NLRC3, a member of the NLR family of proteins, is a negative regulator of innate immune signaling induced by the DNA sensor STING. Immunity 40:329-41
West, John A; Wicks, Megan; Gregory, Sean M et al. (2014) An important role for mitochondrial antiviral signaling protein in the Kaposi's sarcoma-associated herpesvirus life cycle. J Virol 88:5778-87
Canna, Scott W; de Jesus, Adriana A; Gouni, Sushanth et al. (2014) An activating NLRC4 inflammasome mutation causes autoinflammation with recurrent macrophage activation syndrome. Nat Genet 46:1140-6
Giffin, Louise; Yan, Feng; Ben Major, M et al. (2014) Modulation of Kaposi's sarcoma-associated herpesvirus interleukin-6 function by hypoxia-upregulated protein 1. J Virol 88:9429-41
Yamane, Daisuke; McGivern, David R; Wauthier, Eliane et al. (2014) Regulation of the hepatitis C virus RNA replicase by endogenous lipid peroxidation. Nat Med 20:927-35