Under Dr. Jenny Ting, Program Director, the Administrative Core supports the scientific and translational goals of this Center of Excellence for Immune Mechanisms of Virus Control (CEIMVC) by providing leadership and day-to-day operational administration. The Administrative Core is responsible for managing, coordinating, and supervising the overall project. It will coordinate administrative/scientific oversight of all research projects, cores, and pilot programs and the activities ofthe external Scientific Advisory Board (SAB). In addition, this Core is responsible for the day-to-day operations and management, including monitoring of expenditures, addressing grant management issues as well as unexpected issues that arise. The primary goal of the Administrative Core is to promote success for all Center programs by managing, coordinating, and supervising all Center activities. This includes research programs, core activities, pilot research projects, financial monitoring and oversight, compliance and regulatory activities, intellectual property and technology development, biosafety and security issues for all personnel, materials and data sharing plans associated with Center programs. The Administrative Core is ultimately responsible for ensuring the successful completion of the Center's mission to study novel immune mechanisms that are generalizable to anti-viral immunity. We will be assisting all personnel associated with the Program in achieving the goals listed in the Program Abstract, specifically in advancing knowledge regarding novel PRRs that are important for nucleic acid sensing and applying this knowledge to the study of NIAID high priority viral pathogens. The Scientific Administrators and the Administrative Staff will work together toward the stated goals.

Public Health Relevance

The administrative core for the Center of Excellence for Immune Mechanisms of Virus Control is crucial for the research program, regulatory activities, biosafety, security issues, and financial monitoring. Administrative Core is ultimately responsible for ensuring the successful completion ofthe Center's goal of unveiling how novel intracellular Pathogen Recognition Receptors mediate host response to NIAID high priority viruses.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Program--Cooperative Agreements (U19)
Project #
5U19AI109965-03
Application #
9024435
Study Section
Special Emphasis Panel (ZAI1)
Project Start
Project End
Budget Start
2016-03-01
Budget End
2017-02-28
Support Year
3
Fiscal Year
2016
Total Cost
Indirect Cost
Name
University of North Carolina Chapel Hill
Department
Genetics
Type
Schools of Medicine
DUNS #
608195277
City
Chapel Hill
State
NC
Country
United States
Zip Code
27599
Huang, Juin-Hua; Liu, Chu-Yu; Wu, Sheng-Yang et al. (2018) NLRX1 Facilitates Histoplasma capsulatum-Induced LC3-Associated Phagocytosis for Cytokine Production in Macrophages. Front Immunol 9:2761
Zhang, Yugen; Dittmer, Dirk P; Mieczkowski, Piotr A et al. (2018) RIG-I Detects Kaposi's Sarcoma-Associated Herpesvirus Transcripts in a RNA Polymerase III-Independent Manner. MBio 9:
Anders, Penny M; Montgomery, Nathan D; Montgomery, Stephanie A et al. (2018) Human herpesvirus-encoded kinase induces B cell lymphomas in vivo. J Clin Invest 128:2519-2534
Feng, Hui; Lenarcic, Erik M; Yamane, Daisuke et al. (2017) NLRX1 promotes immediate IRF1-directed antiviral responses by limiting dsRNA-activated translational inhibition mediated by PKR. Nat Immunol 18:1299-1309
McKnight, Kevin L; Xie, Ling; González-López, Olga et al. (2017) Protein composition of the hepatitis A virus quasi-envelope. Proc Natl Acad Sci U S A 114:6587-6592
Swanson, Karen V; Junkins, Robert D; Kurkjian, Cathryn J et al. (2017) A noncanonical function of cGAMP in inflammasome priming and activation. J Exp Med 214:3611-3626
Freeman, Leslie; Guo, Haitao; David, Clément N et al. (2017) NLR members NLRC4 and NLRP3 mediate sterile inflammasome activation in microglia and astrocytes. J Exp Med 214:1351-1370
Host, Kurtis M; Jacobs, Sarah R; West, John A et al. (2017) Kaposi's Sarcoma-Associated Herpesvirus Increases PD-L1 and Proinflammatory Cytokine Expression in Human Monocytes. MBio 8:
Ma, Zhe; Hopcraft, Sharon E; Yang, Fan et al. (2017) NLRX1 negatively modulates type I IFN to facilitate KSHV reactivation from latency. PLoS Pathog 13:e1006350
Jha, Sushmita; Brickey, W June; Ting, Jenny Pan-Yun (2017) Inflammasomes in Myeloid Cells: Warriors Within. Microbiol Spectr 5:

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