The Emory University Autoimmunity Center of Excellence U19 will conduct basic and translational research on the B cell and autoantibody underpinnings of SLE and ether human autoimmune diseases. The function of this Administrative Cere A will be te provide support, organization, coordination and efficient management of the ACE. The goals of this Core are: 1. To provide oversight and guidance to all components and investigators of the ACE in order to ensure proper and timely fiscal management and use of human and financial resources. 2. To ensure that all investigators and support personnel are trained and accredited by the Emory Research Subject Review Board (RSRB) and that such training and accreditation is current as mandated by RSRB guidelines. A critical objective of this core will be to ensure patients safety and confidentiality. 3. To facilitate the Interaction between Emory ACE, the organizing center and the ACE Steering Committee. 4. To maximize the coordination and scientific progress of all projects. 5. To coordinate patient recruitment;sample collection and distribution;and data storage, management and sharing. These goals will be accomplished through close Interaction between Dr. Sanz (U19 and Core Director), the Core Manager (Ms. Scantlin) and the Business Administrator (Ms. Critchet), who will oversee grant accounfing support personnel and provide the liaison between the ACE, the NIH and the Emery University of Office of Sponsored Programs (OSP). They will coordinate efforts among Investigators and most Importantly, to ensure patients safety and confidentiality. Ms. Critchet will supervise the preparation and distribution of financial and administrative reports, develop and monitor budgets;monitor expenses and budgets ensuring costs are allowable, allocable, reasonable, and properly authorized. This structure will provide indispensable fiscal oversight and help with timely execution of strategic decisions made by the group. Relevance This Core will enable the Emory ACE U19 investigators to pursue critical research in human autoimmunity in an efficient, safe and productive fashion

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Program--Cooperative Agreements (U19)
Project #
1U19AI110483-01
Application #
8732945
Study Section
Special Emphasis Panel (ZAI1)
Project Start
Project End
Budget Start
2014-05-01
Budget End
2015-04-30
Support Year
1
Fiscal Year
2014
Total Cost
Indirect Cost
Name
Emory University
Department
Type
DUNS #
City
Atlanta
State
GA
Country
United States
Zip Code
30322
Sanz, Iñaki (2017) New Perspectives in Rheumatology: May You Live in Interesting Times: Challenges and Opportunities in Lupus Research. Arthritis Rheumatol 69:1552-1559
Jaworski, Juan Pablo; Bryk, Peter; Brower, Zachary et al. (2017) Pre-existing neutralizing antibody mitigates B cell dysregulation and enhances the Env-specific antibody response in SHIV-infected rhesus macaques. PLoS One 12:e0172524
Sisirak, Vanja; Sally, Benjamin; D'Agati, Vivette et al. (2016) Digestion of Chromatin in Apoptotic Cell Microparticles Prevents Autoimmunity. Cell 166:88-101
Yu, Cuiling; Liu, Yanling; Chan, Justin Tze Ho et al. (2016) Identification of human plasma cells with a lamprey monoclonal antibody. JCI Insight 1:
Sanz, Iñaki (2016) Systemic lupus erythematosus: Extent and patterns of off-label use of rituximab for SLE. Nat Rev Rheumatol 12:700-702
Scharer, Christopher D; Blalock, Emily L; Barwick, Benjamin G et al. (2016) ATAC-seq on biobanked specimens defines a unique chromatin accessibility structure in naïve SLE B cells. Sci Rep 6:27030
Sanz, Ignacio (2016) Editorial: IgA Responses and Future Development of Rheumatoid Arthritis. Arthritis Rheumatol 68:2351-3
Chen, Luojing; Oleksyn, David; Pulvino, Mary et al. (2016) A critical role for the protein kinase PKK in the maintenance of recirculating mature B cells and the development of B1 cells. Immunol Lett 172:67-78
Barwick, Benjamin G; Scharer, Christopher D; Bally, Alexander P R et al. (2016) Plasma cell differentiation is coupled to division-dependent DNA hypomethylation and gene regulation. Nat Immunol 17:1216-1225
Hart, Geoffrey T; Akkaya, Munir; Chida, Asiya S et al. (2016) The Regulation of Inherently Autoreactive VH4-34-Expressing B Cells in Individuals Living in a Malaria-Endemic Area of West Africa. J Immunol 197:3841-3849

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