Abstract

Immune responses are of paramount importance in protection from infectious diseases and vaccines are an exceedingly cost-effective measure to prevent these illnesses. Despite considerable progress, the immunological correlates of protection from enteric infections and malaria, as well as other infectious agents that form part of this Ul 9 application remain unknown. To address these major gaps in knowledge, we will establish an Immunology Core that will generate unique immunological data to be correlated with microbiome, P. falciparum, V. cholerae, ETEC and other unique sequencing data resulting from studies proposed in this U19 application to address unexplored and critical new aspects of host-parasite interactions. The PI of this Immunology Core and his team are extremely experienced in the study of immune responses to infectious agents and vaccine development in humans and animal models using state-of-the-art techniques and instrumentation.

Public Health Relevance

There is a critical need to find new ways to diagnose and treat infectious diseases around the world. The proposed research in this U19 award will use state-of-the-art genomics approaches to study a variety of high-priority pathogens to better understand how they cause disease in infected individuals. This Immunology Core will provide new information about how we respond to infectious diseases.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Program--Cooperative Agreements (U19)
Project #
1U19AI110820-01
Application #
8711767
Study Section
Special Emphasis Panel (ZAI1)
Project Start
2014-04-15
Project End
2019-03-31
Budget Start
2014-04-15
Budget End
2015-03-31
Support Year
1
Fiscal Year
2014
Total Cost
Indirect Cost

  Institution

Name
University of Maryland Baltimore
Department
Type
DUNS #
City
Baltimore
State
MD
Country
United States
Zip Code
21201

  Publications

Liu, Hong; Xu, Wenjie; Solis, Norma V et al. (2018) Functional convergence of gliP and aspf1 in Aspergillus fumigatus pathogenicity. Virulence 9:1062-1073
Richter, Taylor K S; Michalski, Jane M; Zanetti, Luke et al. (2018) Responses of the Human Gut Escherichia coli Population to Pathogen and Antibiotic Disturbances. mSystems 3:
Ouattara, Amed; Tran, Tuan M; Doumbo, Safiatou et al. (2018) Extent and Dynamics of Polymorphism in the Malaria Vaccine Candidate Plasmodium falciparum Reticulocyte-Binding Protein Homologue-5 in Kalifabougou, Mali. Am J Trop Med Hyg 99:43-50
Mendes, António M; Machado, Marta; Gonçalves-Rosa, Nataniel et al. (2018) A Plasmodium berghei sporozoite-based vaccination platform against human malaria. NPJ Vaccines 3:33
Chung, Matthew; Teigen, Laura; Libro, Silvia et al. (2018) Multispecies Transcriptomics Data Set of Brugia malayi, Its Wolbachia Endosymbiont wBm, and Aedes aegypti across the B. malayi Life Cycle. Microbiol Resour Announc 7:
Watkins, Tonya N; Liu, Hong; Chung, Matthew et al. (2018) Comparative transcriptomics of Aspergillus fumigatus strains upon exposure to human airway epithelial cells. Microb Genom :
Robertson, Colin D; Hazen, Tracy H; Kaper, James B et al. (2018) Phosphotyrosine-Mediated Regulation of Enterohemorrhagic Escherichia coli Virulence. MBio 9:
Ndungo, Esther; Randall, Arlo; Hazen, Tracy H et al. (2018) A Novel Shigella Proteome Microarray Discriminates Targets of Human Antibody Reactivity following Oral Vaccination and Experimental Challenge. mSphere 3:
Hazen, Tracy H; Mettus, Roberta; McElheny, Christi L et al. (2018) Diversity among blaKPC-containing plasmids in Escherichia coli and other bacterial species isolated from the same patients. Sci Rep 8:10291
Chung, Matthew; Teigen, Laura; Liu, Hong et al. (2018) Targeted enrichment outperforms other enrichment techniques and enables more multi-species RNA-Seq analyses. Sci Rep 8:13377

Showing the most recent 10 out of 55 publications