Tuberculosis (TB) takes longer to cure than almost any other bacterial infection. Subpopulations of Mycobacterium tuberculosis (Mtb) become phenotypically drug-tolerant in association with host-imposed stresses that put Mtb into a slowly-replicating or non-replicating state (here called NR for simplicity). We hypothesize that NR Mtb represent a major population of the

Public Health Relevance

These studies will address two challenges: to characterize one of the persistent, metabolically diverse Mtb populations of most importance for TB treatment duration and relapse, and to identify early markers of bacterial clearance in response to chemotherapy. This will advance our understanding of Mtb's persistence and help find drugs that can overcome it.

Agency
National Institute of Health (NIH)
Type
Research Program--Cooperative Agreements (U19)
Project #
1U19AI111143-01
Application #
8726600
Study Section
Special Emphasis Panel (ZAI1)
Project Start
Project End
Budget Start
Budget End
Support Year
1
Fiscal Year
2014
Total Cost
Indirect Cost
Name
Weill Medical College of Cornell University
Department
Type
DUNS #
City
New York
State
NY
Country
United States
Zip Code
10065