Public Health Relevance

Many people exposed to the bacteria that cause Tuberculosis (TB) become infected but only a small number will progress to disease. This proposal will develop new tests that can identify people who are either at high risk or low risk of developing TB. The knowledge gained will allow targeting TB treatment to the right group of infected people and preventing them from developing Tb and spreading the bacteria to others.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Program--Cooperative Agreements (U19)
Project #
1U19AI111276-01
Application #
8726578
Study Section
Special Emphasis Panel (ZAI1-LG-M (M1))
Project Start
Project End
Budget Start
2014-08-01
Budget End
2015-07-31
Support Year
1
Fiscal Year
2014
Total Cost
$94,391
Indirect Cost
$15,711
Name
Boston Medical Center
Department
Type
DUNS #
005492160
City
Boston
State
MA
Country
United States
Zip Code
02118
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Peterson, Eliza J R; Ma, Shuyi; Sherman, David R et al. (2016) Network analysis identifies Rv0324 and Rv0880 as regulators of bedaquiline tolerance in Mycobacterium tuberculosis. Nat Microbiol 1:16078
Bhatt, Kamlesh; Verma, Sheetal; Ellner, Jerrold J et al. (2015) Quest for correlates of protection against tuberculosis. Clin Vaccine Immunol 22:258-66
Salgame, Padmini; Geadas, Carolina; Collins, Lauren et al. (2015) Latent tuberculosis infection--Revisiting and revising concepts. Tuberculosis (Edinb) 95:373-84