Public Health Relevance

Many people exposed to the bacteria that cause Tuberculosis (TB) become infected but only a small number will progress to disease. This proposal will develop new tests that can identify people who are either at high risk or low risk of developing TB. The knowledge gained will allow targeting TB treatment to the right group of infected people and preventing them from developing Tb and spreading the bacteria to others.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Program--Cooperative Agreements (U19)
Project #
5U19AI111276-03
Application #
9119764
Study Section
Special Emphasis Panel (ZAI1)
Project Start
Project End
Budget Start
2016-08-01
Budget End
2017-07-31
Support Year
3
Fiscal Year
2016
Total Cost
Indirect Cost
Name
Boston Medical Center
Department
Type
DUNS #
005492160
City
Boston
State
MA
Country
United States
Zip Code
Koch, Anastasia S; Brites, Daniela; Stucki, David et al. (2017) The Influence of HIV on the Evolution of Mycobacterium tuberculosis. Mol Biol Evol 34:1654-1668
Tientcheu, Leopold D; Koch, Anastasia; Ndengane, Mthawelenga et al. (2017) Immunological consequences of strain variation within the Mycobacterium tuberculosis complex. Eur J Immunol 47:432-445
Saito, Kohta; Warrier, Thulasi; Somersan-Karakaya, Selin et al. (2017) Rifamycin action on RNA polymerase in antibiotic-tolerant Mycobacterium tuberculosis results in differentially detectable populations. Proc Natl Acad Sci U S A 114:E4832-E4840
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Prosser, Gareth; Brandenburg, Julius; Reiling, Norbert et al. (2017) The bacillary and macrophage response to hypoxia in tuberculosis and the consequences for T cell antigen recognition. Microbes Infect 19:177-192
Collins, Lauren F; Geadas, Carolina; Ellner, Jerrold J (2016) Diagnosis of Latent Tuberculosis Infection: Too Soon to Pull the Plug on the Tuberculin Skin Test. Ann Intern Med 164:122-4

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