? Administrative Core A strong Administrative Core is essential for providing leadership and infrastructure for both scientific and logistical dimensions of large-scale collaborative efforts such as this proposed multi-site research Center. The goal of this Human Tissue Models for Infectious Diseases Cooperative Research Center (HTMID CRC) is to establish a novel 3D human tissue platform to model viral infections of the developing central nervous system. We therefore need to bring together experts from disparate scientific domains and thus, these objectives to facilitate collaborative interactions become even more critical. By providing the investigators with a single point of contact, the Administrative Core will coordinate all activities, including administrative support, financial support, resource sharing and banking, cross-training of personnel, and data management. There are five major goals of the Administrative Core: to facilitate sharing of resources and collaborations among Center investigators (Aim 1); to coordinate external oversight and timely progression toward milestones for each project (Aim 2); to disseminate all results and methodology to the public in a timely manner (Aim 3); to conduct financial and regulatory oversight (Aim 4); and to solicit applications and award Pilot Developmental Research Project grants (Aim 5). The Administrative Core will provide additional support to the Center by keeping team members apprised of the latest technological advances in data collection, storage, sharing, and analysis. The Administrative Core will also take a proactive stance toward coordinating with other Centers to adopt data structures that can facilitate the eventual sharing of data across Centers. Through these activities, the Administrative Core will support individual investigators, research teams, collaborators and consultants to ensure a successful collaborative effort through centralized coordination of the proposed Projects and Cores.

National Institute of Health (NIH)
National Institute of Allergy and Infectious Diseases (NIAID)
Research Program--Cooperative Agreements (U19)
Project #
Application #
Study Section
Special Emphasis Panel (ZAI1-BLG-M (J2))
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of Pennsylvania
Domestic Higher Education
United States
Zip Code
Christian, Kimberly M; Song, Hongjun; Ming, Guo-Li (2018) A previously undetected pathology of Zika virus infection. Nat Med 24:258-259
Ho, Cheng-Ying; Castillo, Nicolas; Encinales, Liliana et al. (2018) Second-trimester Ultrasound and Neuropathologic Findings in Congenital Zika Virus Infection. Pediatr Infect Dis J 37:1290-1293
Yang, Shu; Xu, Miao; Lee, Emily M et al. (2018) Emetine inhibits Zika and Ebola virus infections through two molecular mechanisms: inhibiting viral replication and decreasing viral entry. Cell Discov 4:31
Lang, Jianshe; Cheng, Yichen; Rolfe, Alyssa et al. (2018) An hPSC-Derived Tissue-Resident Macrophage Model Reveals Differential Responses of Macrophages to ZIKV and DENV Infection. Stem Cell Reports 11:348-362
Song, Guang; Rho, Hee-Sool; Pan, Jianbo et al. (2018) Multiplexed Biomarker Panels Discriminate Zika and Dengue Virus Infection in Humans. Mol Cell Proteomics 17:349-356
Yoon, Ki-Jun; Vissers, Caroline; Ming, Guo-Li et al. (2018) Epigenetics and epitranscriptomics in temporal patterning of cortical neural progenitor competence. J Cell Biol 217:1901-1914
Qian, Xuyu; Jacob, Fadi; Song, Mingxi Max et al. (2018) Generation of human brain region-specific organoids using a miniaturized spinning bioreactor. Nat Protoc 13:565-580
Ye, Fei; Kang, Eunchai; Yu, Chuan et al. (2017) DISC1 Regulates Neurogenesis via Modulating Kinetochore Attachment of Ndel1/Nde1 during Mitosis. Neuron 96:1041-1054.e5
Yoon, Ki-Jun; Song, Guang; Qian, Xuyu et al. (2017) Zika-Virus-Encoded NS2A Disrupts Mammalian Cortical Neurogenesis by Degrading Adherens Junction Proteins. Cell Stem Cell 21:349-358.e6
Wen, Zhexing; Song, Hongjun; Ming, Guo-Li (2017) How does Zika virus cause microcephaly? Genes Dev 31:849-861

Showing the most recent 10 out of 16 publications