In this project we will explore highly innovative planning and delivery strategies to optimally utilize the powerful dose shaping capabilities of IMPT. The theoretical advantage of proton therapy compared to photon therapy is due to the reduced integral dose (""""""""dose bath"""""""") and the finite range. The added potential of IMPT compared to IMRT derives from the additional degree of freedom, i.e. the beamlet energy. However, to realize the true potential of IMPT, considerable further research is needed.
The specific aims of this project focus on different aspects that influence the power of IMPT: Robust optimization of the dose distributions to reduce their sensitivity to uncertainties, biological dose optimization, personalized treatment optimization, and finally, hypofractionation facilitated via the reduced dose bath achievable with IMPT. This project supports the mission of the NCI to improve the treatment and continuing care of cancer patients.
This research aims to improve radiation treatment for cancer patients by improving our ability to direct the radiation at the tumor to spare adjacent normal tissue by using protons (charged particles) with intensity-modulated proton therapy. This can potentially improve cancer cure rates, reduce side effects, or both, depending on the clinical scenario. With an increasing number of proton centers in the United States and abroad, the research in this program project is increasingly important for public health.
|Niedzielski, Joshua S; Yang, Jinzhong; Liao, Zhongxing et al. (2016) (18)F-Fluorodeoxyglucose Positron Emission Tomography Can Quantify and Predict Esophageal Injury During Radiation Therapy. Int J Radiat Oncol Biol Phys 96:670-8|
|Gunn, G Brandon; Blanchard, Pierre; Garden, Adam S et al. (2016) Clinical Outcomes and Patterns of Disease Recurrence After Intensity Modulated Proton Therapy for Oropharyngeal Squamous Carcinoma. Int J Radiat Oncol Biol Phys 95:360-7|
|Hall, David C; Makarova, Anastasia; Paganetti, Harald et al. (2016) Validation of nuclear models in Geant4 using the dose distribution of a 177 MeV proton pencil beam. Phys Med Biol 61:N1-N10|
|Unkelbach, Jan; Botas, Pablo; Giantsoudi, Drosoula et al. (2016) Reoptimization of Intensity Modulated Proton Therapy Plans Based on Linear Energy Transfer. Int J Radiat Oncol Biol Phys 96:1097-1106|
|Niedzielski, Joshua S; Yang, Jinzhong; Stingo, Francesco et al. (2016) Objectively Quantifying Radiation Esophagitis With Novel Computed Tomography-Based Metrics. Int J Radiat Oncol Biol Phys 94:385-93|
|Wang, Xin Shelley; Shi, Qiuling; Williams, Loretta A et al. (2016) Prospective Study of Patient-Reported Symptom Burden in Patients With Non-Small-Cell Lung Cancer Undergoing Proton or Photon Chemoradiation Therapy. J Pain Symptom Manage 51:832-8|
|Underwood, Tracy; Paganetti, Harald (2016) Variable Proton Relative Biological Effectiveness: How Do We Move Forward? Int J Radiat Oncol Biol Phys 95:56-8|
|Unkelbach, Jan; BussiÃ¨re, Marc R; Chapman, Paul H et al. (2016) Spatiotemporal Fractionation Schemes for Irradiating Large Cerebral Arteriovenous Malformations. Int J Radiat Oncol Biol Phys 95:1067-74|
|Taylor, Paige A; Kry, Stephen F; Alvarez, Paola et al. (2016) Results From the Imaging and Radiation Oncology Core Houston's Anthropomorphic Phantoms Used for Proton Therapy Clinical Trial Credentialing. Int J Radiat Oncol Biol Phys 95:242-8|
|Peeler, Christopher R; Mirkovic, Dragan; Titt, Uwe et al. (2016) Clinical evidence of variable proton biological effectiveness in pediatric patients treated for ependymoma. Radiother Oncol :|
Showing the most recent 10 out of 15 publications