The specific aims of the Administrative Core (A) are to provide centralized scientific and administrative management, financial control services, and clerical and materials management support to all projects and cores. The Administrative Core will provide necessary support for the organization and conduct of the Steering Committee /Internal Advisory Board meetings, the annual Investigator Meeting and Retreat with the External Advisory Board, and monthly or as-needed telephone, video, and web conferences. This core supports the mission of the NCI to improve the treatment and continuing care of cancer patients.

Public Health Relevance

This research aims to improve radiafion treatment for cancer patients by improving our ability to direct the radiation at the tumor to spare adjacent normal tissue by using protons (charged particles) with intensity- modulated proton therapy. This can potentially improve cancer cure rates, reduce side effects, or both, depending on the clinical scenario. With an increasing number of proton centers in the United States and abroad, the research in this program project is increasingly important for public health.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Program--Cooperative Agreements (U19)
Project #
2U19CA021239-35
Application #
8716852
Study Section
Special Emphasis Panel (ZCA1-RPRB-C (J1))
Project Start
1997-04-01
Project End
2019-08-31
Budget Start
2014-09-25
Budget End
2015-08-31
Support Year
35
Fiscal Year
2014
Total Cost
$124,102
Indirect Cost
$25,843
Name
Massachusetts General Hospital
Department
Type
DUNS #
073130411
City
Boston
State
MA
Country
United States
Zip Code
02199
Guan, Fada; Geng, Changran; Ma, Duo et al. (2018) RBE Model-Based Biological Dose Optimization for Proton Radiobiology Studies. Int J Part Ther 5:160-171
Liao, Zhongxing; Simone 2nd, Charles B (2018) Particle therapy in non-small cell lung cancer. Transl Lung Cancer Res 7:141-152
Blanchard, Pierre; Gunn, Gary Brandon; Lin, Alexander et al. (2018) Proton Therapy for Head and Neck Cancers. Semin Radiat Oncol 28:53-63
Chen, Yizheng; Grassberger, Clemens; Li, Junli et al. (2018) Impact of potentially variable RBE in liver proton therapy. Phys Med Biol 63:195001
Geng, Changran; Gates, Drake; Bronk, Lawrence et al. (2018) Physical parameter optimization scheme for radiobiological studies of charged particle therapy. Phys Med 51:13-21
Liao, Zhongxing; Lee, J Jack; Komaki, Ritsuko et al. (2018) Bayesian Adaptive Randomization Trial of Passive Scattering Proton Therapy and Intensity-Modulated Photon Radiotherapy for Locally Advanced Non-Small-Cell Lung Cancer. J Clin Oncol 36:1813-1822
Yepes, Pablo; Adair, Antony; Grosshans, David et al. (2018) Comparison of Monte Carlo and analytical dose computations for intensity modulated proton therapy. Phys Med Biol 63:045003
Unkelbach, Jan; Paganetti, Harald (2018) Robust Proton Treatment Planning: Physical and Biological Optimization. Semin Radiat Oncol 28:88-96
Vassiliev, Oleg N; Kry, Stephen F; Grosshans, David R et al. (2018) Average stopping powers for electron and photon sources for radiobiological modeling and microdosimetric applications. Phys Med Biol 63:055007
Paganetti, Harald (2018) Proton Relative Biological Effectiveness - Uncertainties and Opportunities. Int J Part Ther 5:2-14

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