The specific aims of the Administrative Core (A) are to provide centralized scientific and administrative management, financial control services, and clerical and materials management support to all projects and cores. The Administrative Core will provide necessary support for the organization and conduct of the Steering Committee /Internal Advisory Board meetings, the annual Investigator Meeting and Retreat with the External Advisory Board, and monthly or as-needed telephone, video, and web conferences. This core supports the mission of the NCI to improve the treatment and continuing care of cancer patients.

Public Health Relevance

This research aims to improve radiafion treatment for cancer patients by improving our ability to direct the radiation at the tumor to spare adjacent normal tissue by using protons (charged particles) with intensity- modulated proton therapy. This can potentially improve cancer cure rates, reduce side effects, or both, depending on the clinical scenario. With an increasing number of proton centers in the United States and abroad, the research in this program project is increasingly important for public health.

National Institute of Health (NIH)
National Cancer Institute (NCI)
Research Program--Cooperative Agreements (U19)
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Special Emphasis Panel (ZCA1-RPRB-C (J1))
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Massachusetts General Hospital
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Taylor, Paige A; Kry, Stephen F; Followill, David S (2017) Pencil Beam Algorithms Are Unsuitable for Proton Dose Calculations in Lung. Int J Radiat Oncol Biol Phys 99:750-756
DeLaney, Thomas F; Chen, Yen-Lin; Baldini, Elizabeth H et al. (2017) Phase 1 trial of preoperative image guided intensity modulated proton radiation therapy with simultaneously integrated boost to the high risk margin for retroperitoneal sarcomas. Adv Radiat Oncol 2:85-93
Mohan, Radhe; Grosshans, David (2017) Proton therapy - Present and future. Adv Drug Deliv Rev 109:26-44
Hall, David C; Trofimov, Alexei V; Winey, Brian A et al. (2017) Predicting Patient-specific Dosimetric Benefits of Proton Therapy for Skull-base Tumors Using a Geometric Knowledge-based Method. Int J Radiat Oncol Biol Phys 97:1087-1094
Zaghian, Maryam; Cao, Wenhua; Liu, Wei et al. (2017) Comparison of linear and nonlinear programming approaches for ""worst case dose"" and ""minmax"" robust optimization of intensity-modulated proton therapy dose distributions. J Appl Clin Med Phys 18:15-25
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Mohan, Radhe; Das, Indra J; Ling, Clifton C (2017) Empowering Intensity Modulated Proton Therapy Through Physics and Technology: An Overview. Int J Radiat Oncol Biol Phys 99:304-316
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Niedzielski, Joshua S; Yang, Jinzhong; Stingo, Francesco et al. (2017) A Novel Methodology using CT Imaging Biomarkers to Quantify Radiation Sensitivity in the Esophagus with Application to Clinical Trials. Sci Rep 7:6034
Giantsoudi, Drosoula; Adams, Judith; MacDonald, Shannon M et al. (2017) Proton Treatment Techniques for Posterior Fossa Tumors: Consequences for Linear Energy Transfer and Dose-Volume Parameters for the Brainstem and Organs at Risk. Int J Radiat Oncol Biol Phys 97:401-410

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