The specific aims of the Administrative Core (A) are to provide centralized scientific and administrative management, financial control services, and clerical and materials management support to all projects and cores. The Administrative Core will provide necessary support for the organization and conduct of the Steering Committee /Internal Advisory Board meetings, the annual Investigator Meeting and Retreat with the External Advisory Board, and monthly or as-needed telephone, video, and web conferences. This core supports the mission of the NCI to improve the treatment and continuing care of cancer patients.
This research aims to improve radiafion treatment for cancer patients by improving our ability to direct the radiation at the tumor to spare adjacent normal tissue by using protons (charged particles) with intensity- modulated proton therapy. This can potentially improve cancer cure rates, reduce side effects, or both, depending on the clinical scenario. With an increasing number of proton centers in the United States and abroad, the research in this program project is increasingly important for public health.
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|Mohan, Radhe; Grosshans, David (2017) Proton therapy - Present and future. Adv Drug Deliv Rev 109:26-44|
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|Zaghian, Maryam; Cao, Wenhua; Liu, Wei et al. (2017) Comparison of linear and nonlinear programming approaches for ""worst case dose"" and ""minmax"" robust optimization of intensity-modulated proton therapy dose distributions. J Appl Clin Med Phys 18:15-25|
|Mohan, Radhe; Peeler, Christopher R; Guan, Fada et al. (2017) Radiobiological issues in proton therapy. Acta Oncol 56:1367-1373|
|Mohan, Radhe; Das, Indra J; Ling, Clifton C (2017) Empowering Intensity Modulated Proton Therapy Through Physics and Technology: An Overview. Int J Radiat Oncol Biol Phys 99:304-316|
|Unkelbach, Jan; Papp, Dávid; Gaddy, Melissa R et al. (2017) Spatiotemporal fractionation schemes for liver stereotactic body radiotherapy. Radiother Oncol 125:357-364|
|Niedzielski, Joshua S; Yang, Jinzhong; Stingo, Francesco et al. (2017) A Novel Methodology using CT Imaging Biomarkers to Quantify Radiation Sensitivity in the Esophagus with Application to Clinical Trials. Sci Rep 7:6034|
|Giantsoudi, Drosoula; Adams, Judith; MacDonald, Shannon M et al. (2017) Proton Treatment Techniques for Posterior Fossa Tumors: Consequences for Linear Energy Transfer and Dose-Volume Parameters for the Brainstem and Organs at Risk. Int J Radiat Oncol Biol Phys 97:401-410|
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