This core is a central resource to support clinical trials and physics research and MD Anderson Cancer Center (MDACC). Core B provides the following services: (1) support for proton and photon treatment planning;(2) quality assurance and delivery of treatments for patients enrolled in the clinical trials of Projects 1 and 2;(3) robustness evaluation and robust optimization of the proton treatment plans and treatment delivery for IMPT;(4) measurements for experimental verification and validation of computed dose distributions;(5) clinical physics support for credentialing for the trials described in Projects 1 and 2;and (6) dose computations with highly accurate methods including those employing Monte Carlo techniques. This core will also maintain, enhance and support the use of computational and optimization hardware and software infrastructure for treatment planning and QA for Projects 1 and 2 and for physics research in Projects 3 and 4. This core supports the mission of the NCI to improve the treatment and continuing care of cancer patients.

Public Health Relevance

This research aims to improve radiation treatment for cancer patients by improving our ability to direct the radiation at the tumor to spare adjacent normal tissue by using protons (charged particles) with intensity- modulated proton therapy. This can potentially improve cancer cure rates, reduce side effects, or both, depending on the clinical scenario. With an increasing number of proton centers in the United States and abroad, the research in this program project is increasingly important for public health.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Program--Cooperative Agreements (U19)
Project #
2U19CA021239-35
Application #
8716859
Study Section
Special Emphasis Panel (ZCA1-RPRB-C (J1))
Project Start
1997-04-01
Project End
2019-08-31
Budget Start
2014-09-25
Budget End
2015-08-31
Support Year
35
Fiscal Year
2014
Total Cost
$383,428
Indirect Cost
$79,842
Name
Massachusetts General Hospital
Department
Type
DUNS #
073130411
City
Boston
State
MA
Country
United States
Zip Code
02199
Taylor, Paige A; Kry, Stephen F; Followill, David S (2017) Pencil Beam Algorithms Are Unsuitable for Proton Dose Calculations in Lung. Int J Radiat Oncol Biol Phys 99:750-756
DeLaney, Thomas F; Chen, Yen-Lin; Baldini, Elizabeth H et al. (2017) Phase 1 trial of preoperative image guided intensity modulated proton radiation therapy with simultaneously integrated boost to the high risk margin for retroperitoneal sarcomas. Adv Radiat Oncol 2:85-93
Mohan, Radhe; Grosshans, David (2017) Proton therapy - Present and future. Adv Drug Deliv Rev 109:26-44
Hall, David C; Trofimov, Alexei V; Winey, Brian A et al. (2017) Predicting Patient-specific Dosimetric Benefits of Proton Therapy for Skull-base Tumors Using a Geometric Knowledge-based Method. Int J Radiat Oncol Biol Phys 97:1087-1094
Zaghian, Maryam; Cao, Wenhua; Liu, Wei et al. (2017) Comparison of linear and nonlinear programming approaches for ""worst case dose"" and ""minmax"" robust optimization of intensity-modulated proton therapy dose distributions. J Appl Clin Med Phys 18:15-25
Mohan, Radhe; Peeler, Christopher R; Guan, Fada et al. (2017) Radiobiological issues in proton therapy. Acta Oncol 56:1367-1373
Mohan, Radhe; Das, Indra J; Ling, Clifton C (2017) Empowering Intensity Modulated Proton Therapy Through Physics and Technology: An Overview. Int J Radiat Oncol Biol Phys 99:304-316
Unkelbach, Jan; Papp, Dávid; Gaddy, Melissa R et al. (2017) Spatiotemporal fractionation schemes for liver stereotactic body radiotherapy. Radiother Oncol 125:357-364
Niedzielski, Joshua S; Yang, Jinzhong; Stingo, Francesco et al. (2017) A Novel Methodology using CT Imaging Biomarkers to Quantify Radiation Sensitivity in the Esophagus with Application to Clinical Trials. Sci Rep 7:6034
Giantsoudi, Drosoula; Adams, Judith; MacDonald, Shannon M et al. (2017) Proton Treatment Techniques for Posterior Fossa Tumors: Consequences for Linear Energy Transfer and Dose-Volume Parameters for the Brainstem and Organs at Risk. Int J Radiat Oncol Biol Phys 97:401-410

Showing the most recent 10 out of 34 publications