This core is a central resource to support clinical trials and physics research and MD Anderson Cancer Center (MDACC). Core B provides the following services: (1) support for proton and photon treatment planning;(2) quality assurance and delivery of treatments for patients enrolled in the clinical trials of Projects 1 and 2;(3) robustness evaluation and robust optimization of the proton treatment plans and treatment delivery for IMPT;(4) measurements for experimental verification and validation of computed dose distributions;(5) clinical physics support for credentialing for the trials described in Projects 1 and 2;and (6) dose computations with highly accurate methods including those employing Monte Carlo techniques. This core will also maintain, enhance and support the use of computational and optimization hardware and software infrastructure for treatment planning and QA for Projects 1 and 2 and for physics research in Projects 3 and 4. This core supports the mission of the NCI to improve the treatment and continuing care of cancer patients.
This research aims to improve radiation treatment for cancer patients by improving our ability to direct the radiation at the tumor to spare adjacent normal tissue by using protons (charged particles) with intensity- modulated proton therapy. This can potentially improve cancer cure rates, reduce side effects, or both, depending on the clinical scenario. With an increasing number of proton centers in the United States and abroad, the research in this program project is increasingly important for public health.
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|Niedzielski, Joshua S; Yang, Jinzhong; Stingo, Francesco et al. (2017) A Novel Methodology using CT Imaging Biomarkers to Quantify Radiation Sensitivity in the Esophagus with Application to Clinical Trials. Sci Rep 7:6034|
|Giantsoudi, Drosoula; Adams, Judith; MacDonald, Shannon M et al. (2017) Proton Treatment Techniques for Posterior Fossa Tumors: Consequences for Linear Energy Transfer and Dose-Volume Parameters for the Brainstem and Organs at Risk. Int J Radiat Oncol Biol Phys 97:401-410|
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