The NIH Roadmap and NCI strategic plans repeatedly invoke the need for greater involvement of healthcare systems in research. Integrated delivery systems, which provide comprehensive care from prevention to palliation, can address key research questions about cancer prevention and control that cannot be answered in many other settings. A consortium of healthcare systems with internal research capabilities creates an unprecedented opportunity to study variations in policy and patterns of cancer prevention and care. In recognition of this potential, the National Cancer Institute issued a Request for Applications in 1997 to """"""""facilitate the conduct of NCI sponsored research on cancer prevention...detection... [and] treatment"""""""" through collaboration among health care delivery systems. In response a group of HMOs (10 collaborators initially, and 13 in the proposed application), formed the HMO Cancer Research Network (CRN), whose overall objective is to conduct research that improves the effectiveness of cancer prevention and treatment through research that identifies individual, provider, system and treatment factors that affect outcomes. We propose herein a research infrastructure and array of projects that capitalize on the unique facets and contributions of a network of delivery systems. The proposed Cancer Research Network consists of four cores, five projects, and a research emphasis on translation of cancer care innovations in community settings. The CRN infrastructure supports our overall goals through a rich, interconnected set of shared resources, and collectively, the projects exploit the CRN's geographic diversity and its sophisticated automated data capabilities. CRN projects are designed to pinpoint the ways in which community-based health care systems can best respond to their enrolled members by: 1) ensuring that they receive the right cancer prevention services;2) devising cancer prevention messages that are readily understood and used;3) providing treatment that is both effective and cost effective to those patients with cancer;and 4) responding holistically to patients'physical and psychosocial needs. Research in the CRN will be readily applicable across health care settings and will contribute to overall improvements in the quality of cancer care.

National Institute of Health (NIH)
National Cancer Institute (NCI)
Research Program--Cooperative Agreements (U19)
Project #
Application #
Study Section
Special Emphasis Panel (ZCA1-SRRB-Y (J2))
Program Officer
Pressman, Emilee J
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Group Health Cooperative
United States
Zip Code
Engmann, Natalie J; Ergas, Isaac J; Yao, Song et al. (2017) Genetic Ancestry Is not Associated with Breast Cancer Recurrence or Survival in U.S. Latina Women Enrolled in the Kaiser Permanente Pathways Study. Cancer Epidemiol Biomarkers Prev 26:1466-1469
Lieu, Tracy A; Ray, G Thomas; Prausnitz, Stephanie R et al. (2017) Oncologist and organizational factors associated with variation in breast cancer multigene testing. Breast Cancer Res Treat 163:167-176
Hassett, Michael J; Uno, Hajime; Cronin, Angel M et al. (2017) Survival after recurrence of stage I-III breast, colorectal, or lung cancer. Cancer Epidemiol 49:186-194
Kimmick, Gretchen G; Major, Brittny; Clapp, Jonathan et al. (2017) Using ePrognosis to estimate 2-year all-cause mortality in older women with breast cancer: Cancer and Leukemia Group B (CALGB) 49907 and 369901 (Alliance A151503). Breast Cancer Res Treat 163:391-398
Mazor, Kathleen M; Rubin, Donald L; Roblin, Douglas W et al. (2016) Health literacy-listening skill and patient questions following cancer prevention and screening discussions. Health Expect 19:920-34
Walsh, Kathleen; Ryan, Jamie; Daraiseh, Nancy et al. (2016) Errors and Nonadherence in Pediatric Oral Chemotherapy Use. Oncology 91:231-236
Ray, G Thomas; Mandelblatt, Jeanne; Habel, Laurel A et al. (2016) Breast cancer multigene testing trends and impact on chemotherapy use. Am J Manag Care 22:e153-60
Hassett, Michael J; Jiang, Wei; Habel, Laurel A et al. (2016) Characteristics of second breast events among women treated with breast-conserving surgery for DCIS in the community. Breast Cancer Res Treat 155:541-9
Asgari, Maryam M; Moffet, Howard H; Ray, G Thomas et al. (2015) Trends in Basal Cell Carcinoma Incidence and Identification of High-Risk Subgroups, 1998-2012. JAMA Dermatol 151:976-81
Weinmann, Sheila; Williams, Andrew E; Kamineni, Aruna et al. (2015) Cervical cancer screening and follow-up in 4 geographically diverse US health care systems, 1998 through 2007. Cancer 121:2976-83

Showing the most recent 10 out of 179 publications