The proposed research seeks to expand our understanding of epithelial ovarian cancer through a coordinated and comprehensive approach that will focus on three main areas. The general themes are shown in Table A. 1. Table A.1 Scope of the proposed studies and expected outcomes. Focus Areas Discovery expansion and replication Biological studies Epidemiologic studies Expected outcomes ? New associations and independent replication ? New findings by histologic subtype ? New markers: copy number variants ? New endpoints: overall survival ? Identify functional consequences of variants ? Improve understanding of biological mechanisms ? Gene x gene interaction ? Gene x environment interaction ? Risk prediction models

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Program--Cooperative Agreements (U19)
Project #
5U19CA148112-04
Application #
8504773
Study Section
Special Emphasis Panel (ZCA1-SRLB-4)
Project Start
Project End
Budget Start
2013-07-01
Budget End
2014-06-30
Support Year
4
Fiscal Year
2013
Total Cost
$305,598
Indirect Cost
$93,079
Name
H. Lee Moffitt Cancer Center & Research Institute
Department
Type
DUNS #
139301956
City
Tampa
State
FL
Country
United States
Zip Code
33612
(2016) Identification of four novel susceptibility loci for oestrogen receptor negative breast cancer. Nat Commun 7:11375
Zhao, Zhiguo; Wen, Wanqing; Michailidou, Kyriaki et al. (2016) Association of genetic susceptibility variants for type 2 diabetes with breast cancer risk in women of European ancestry. Cancer Causes Control 27:679-93
Cheng, Timothy H T; Thompson, Deborah J; O'Mara, Tracy A et al. (2016) Five endometrial cancer risk loci identified through genome-wide association analysis. Nat Genet 48:667-74
(2016) Genome-Wide Meta-Analyses of Breast, Ovarian, and Prostate Cancer Association Studies Identify Multiple New Susceptibility Loci Shared by at Least Two Cancer Types. Cancer Discov 6:1052-67
Saunders, Edward J; Dadaev, Tokhir; Leongamornlert, Daniel A et al. (2016) Gene and pathway level analyses of germline DNA-repair gene variants and prostate cancer susceptibility using the iCOGS-genotyping array. Br J Cancer 114:945-52
Shi, Jiajun; Zhang, Yanfeng; Zheng, Wei et al. (2016) Fine-scale mapping of 8q24 locus identifies multiple independent risk variants for breast cancer. Int J Cancer 139:1303-17
Lei, Jieping; Rudolph, Anja; Moysich, Kirsten B et al. (2016) Genetic variation in the immunosuppression pathway genes and breast cancer susceptibility: a pooled analysis of 42,510 cases and 40,577 controls from the Breast Cancer Association Consortium. Hum Genet 135:137-54
Gusev, Alexander; Shi, Huwenbo; Kichaev, Gleb et al. (2016) Atlas of prostate cancer heritability in European and African-American men pinpoints tissue-specific regulation. Nat Commun 7:10979
Winham, Stacey J; Pirie, Ailith; Chen, Yian Ann et al. (2016) Investigation of Exomic Variants Associated with Overall Survival in Ovarian Cancer. Cancer Epidemiol Biomarkers Prev 25:446-54
Muranen, Taru A; Greco, Dario; Blomqvist, Carl et al. (2016) Genetic modifiers of CHEK2*1100delC-associated breast cancer risk. Genet Med :

Showing the most recent 10 out of 114 publications