The FDA is now required to evaluate and regulate tobacco products toward the goal of protecting public health. This study will develop animal models to assess the relative abuse liability of several tobacco products using aqueous extracts of those products that provide a range of constituents similar to product exposure in humans. In concert with humans studies in this POI, these models may be useful for anficipafing the likelihood and extent of population-level abuse of new tobacco products in humans and its associated impact on public health. They may also help understand how chemicals other than nicotine contribute to tobacco addiction and suggest relevant performance standards for tobacco products to limit or reduce their addictiveness.
|Bickel, Warren K; Johnson, Matthew W; Koffarnus, Mikhail N et al. (2014) The behavioral economics of substance use disorders: reinforcement pathologies and their repair. Annu Rev Clin Psychol 10:641-77|
|Ho, Yen-Yi; Baechler, Emily C; Ortmann, Ward et al. (2014) Using gene expression to improve the power of genome-wide association analysis. Hum Hered 78:94-103|
|Vogel, Rachel Isaksson; Hertsgaard, Louise A; Dermody, Sarah S et al. (2014) Sex differences in response to reduced nicotine content cigarettes. Addict Behav 39:1197-204|
|Bickel, Warren K; Koffarnus, Mikhail N; Moody, Lara et al. (2014) The behavioral- and neuro-economic process of temporal discounting: A candidate behavioral marker of addiction. Neuropharmacology 76 Pt B:518-27|