Abstract

Public Health Relevance

The FDA is now required to evaluate and regulate tobacco products toward the goal of protecting public health. This study will develop animal models to assess the relative abuse liability of several tobacco products using aqueous extracts of those products that provide a range of constituents similar to product exposure in humans. In concert with humans studies in this POI, these models may be useful for anficipafing the likelihood and extent of population-level abuse of new tobacco products in humans and its associated impact on public health. They may also help understand how chemicals other than nicotine contribute to tobacco addiction and suggest relevant performance standards for tobacco products to limit or reduce their addictiveness.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Program--Cooperative Agreements (U19)
Project #
5U19CA157345-02
Application #
8558742
Study Section
Special Emphasis Panel (ZCA1-RPRB-7)
Project Start
Project End
Budget Start
2013-09-01
Budget End
2014-08-31
Support Year
2
Fiscal Year
2013
Total Cost
$371,592
Indirect Cost
$89,116

  Institution

Name
University of Minnesota Twin Cities
Department
Type
DUNS #
555917996
City
Minneapolis
State
MN
Country
United States
Zip Code
55455

  Publications

Bunney, Patricia E; Hansen, Mylissa; LeSage, Mark (2018) Effects of isolated tobacco alkaloids and tobacco products on deprivation-induced food intake and meal patterns in rats. Pharmacol Biochem Behav 165:45-55
LeSage, Mark G; Smethells, John R; Harris, Andrew C (2018) Status and Future Directions of Preclinical Behavioral Pharmacology in Tobacco Regulatory Science. Behav Anal (Wash D C) 18:252-274
Berman, Micah L; Hatsukami, Dorothy K (2018) Reducing tobacco-related harm: FDA's proposed product standard for smokeless tobacco. Tob Control 27:352-354
Stein, Jeffrey S; Koffarnus, Mikhail N; Stepanov, Irina et al. (2018) Cigarette and e-liquid demand and substitution in e-cigarette-naïve smokers. Exp Clin Psychopharmacol 26:233-243
Harris, Andrew C; Muelken, Peter; Smethells, John R et al. (2018) Effects of nicotine-containing and ""nicotine-free"" e-cigarette refill liquids on intracranial self-stimulation in rats. Drug Alcohol Depend 185:1-9
Smethells, John R; Harris, Andrew C; Burroughs, Danielle et al. (2018) Substitutability of nicotine alone and an electronic cigarette liquid using a concurrent choice assay in rats: A behavioral economic analysis. Drug Alcohol Depend 185:58-66
Smith, Tracy T; Hatsukami, Dorothy K; Benowitz, Neal L et al. (2018) Whether to push or pull? Nicotine reduction and non-combusted alternatives - Two strategies for reducing smoking and improving public health. Prev Med 117:8-14
Bickel, Warren K; Mellis, Alexandra M; Snider, Sarah E et al. (2018) 21st century neurobehavioral theories of decision making in addiction: Review and evaluation. Pharmacol Biochem Behav 164:4-21
Harris, Andrew C; Muelken, Peter; Haave, Zach et al. (2018) Propylene glycol, a major electronic cigarette constituent, attenuates the adverse effects of high-dose nicotine as measured by intracranial self-stimulation in rats. Drug Alcohol Depend 193:162-168
Ho, Yen-Yi; Nhu Vo, Tien; Chu, Haitao et al. (2018) A Bayesian hierarchical model for demand curve analysis. Stat Methods Med Res 27:2038-2049

Showing the most recent 10 out of 58 publications