Core Leader:
Ch aim Putterman. A central element of the U19 grant is the collection and characterization of patients with systemic lupus erythematosus (SLE), related autoimmune conditions, and normal controls. This requires protocol-driven identification of subjects, standardized recording of medical history, epidemiological information, family history, and the collection and storage of high-quality biospecimens. Underpinning all of this is a secure, accessible database assuring data integrity and interoperability.
The specific aims of the Clinical Resource Core (CRC) are: 1. Recruitment of subjects with SLE and related conditions, disease controls, and healthy controls; 2. Collection of demographic, clinical, and epidemiological data with storage in a secure, confidential database; 3. Collection and storage of serum, urine, DNA, and RNA for distribution to researchers in this program, from affected and unaffected family members. 4. Immortalization of B cells to provide a resource of cells for isolation of stress-related RNPs and testing of immunomodulatory effects

Public Health Relevance

Several aims in collaborative projects rely on the use of material derived from human subjects. In order to facilitate these projects, we will use a CRC facility for the recruitment subjects, centralized collection of information and specimens for use by multiple investigators, and computational support. Archiving of DNA form affected and unaffected family members will facilitate future genomic sequencing studies.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Program--Cooperative Agreements (U19)
Project #
1U19CA179564-01
Application #
8590507
Study Section
Special Emphasis Panel (ZRG1-OBT-S (50))
Project Start
2013-09-01
Project End
2018-08-31
Budget Start
2013-09-01
Budget End
2014-08-31
Support Year
1
Fiscal Year
2013
Total Cost
$403,561
Indirect Cost
$68,367
Name
Rockefeller University
Department
Type
DUNS #
071037113
City
New York
State
NY
Country
United States
Zip Code
10065
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Ren, Aiming; Patel, Dinshaw J (2014) c-di-AMP binds the ydaO riboswitch in two pseudo-symmetry-related pockets. Nat Chem Biol 10:780-6