The initial period of funding for the Functional Atlas of Nuclear Receptors has demonstrated the ability of the Consortium members to pursue the collective goal of generation and validation of high-content datasets and the distribution of these data to the wider community through a central web portal. In doing so, we greatly exceeded all of the specific aims articulated in the original application and fulfilled our mission of providing discovery-driven research datasets to the wider community with a rich data framework that provides a basis for new ideas and directions for their research. Moreover, we also demonstrated our ability to engage the wider nuclear receptor community to participate in the annotation of the resource by initiating the only active, peer reviewed, free access journal dedicated entirely to nuclear receptors (NRs). Over the four years of funding to date however, there has been an increasing emphasis placed by the sponsoring agencies involved on the need for the Consortium to establish strategies that will result in the generation and dissemination of datasets and methodologies of a more translational character. Accordingly, the scientific scope of the Consortium has shifted to reflect this emphasis. Our goals for the second phase of funding are: (1) to define the temporal and spatial physiology of NRs and to relate normal mechanisms to that of pathologic states in obesity, diabetes, cardiovascular, metabolic, toxic/environmental, senescent, oncologic, and reproductive diseases;(2) to define normal hormonal/environmental signaling to coregulator (coactivators and corepressors) complexes and to relate such signaling to the aforementioned diseases by construction of new animal models for human diseases. As in the previous funding period, we will continue to: acquire large data sets of information on NRs and coregulators that are not easily possible in R01 funded laboratories and to quickly disseminate this data world-wide to investigators in the NR/coregulator field;refine and develop new approaches to manipulate data and distribute it via the NURSA website;collect protocols, new techniques, investigative materials, animal models, and expert scientific opinions/perspectives, and provide them to the non-NURSA community for their use in laboratory/clinical investigations;and finally, we will accomplish all of the above in the context of modern genomic and proteomic technologies, and in the most cost effective and efficient manner possible.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Program--Cooperative Agreements (U19)
Project #
5U19DK062434-10
Application #
8111780
Study Section
Special Emphasis Panel (ZDK1-GRB-9 (M1))
Program Officer
Silva, Corinne M
Project Start
2002-08-15
Project End
2012-06-30
Budget Start
2011-07-01
Budget End
2012-06-30
Support Year
10
Fiscal Year
2011
Total Cost
$2,739,320
Indirect Cost
Name
Baylor College of Medicine
Department
Anatomy/Cell Biology
Type
Schools of Medicine
DUNS #
051113330
City
Houston
State
TX
Country
United States
Zip Code
77030
Kim, Kang Ho; Choi, Sungwoo; Zhou, Ying et al. (2017) Hepatic FXR/SHP axis modulates systemic glucose and fatty acid homeostasis in aged mice. Hepatology 66:498-509
Wagner, Martin; Choi, Sungwoo; Panzitt, Katrin et al. (2016) Liver receptor homolog-1 is a critical determinant of methyl-pool metabolism. Hepatology 63:95-106
Han, Sang Jun; Begum, Khurshida; Foulds, Charles E et al. (2016) The Dual Estrogen Receptor ? Inhibitory Effects of the Tissue-Selective Estrogen Complex for Endometrial and Breast Safety. Mol Pharmacol 89:14-26
Fleet, Tiffany; Stashi, Erin; Zhu, Bokai et al. (2016) Genetic and Environmental Models of Circadian Disruption Link SRC-2 Function to Hepatic Pathology. J Biol Rhythms 31:443-60
Wu, San-Pin; Kao, Chung-Yang; Wang, Leiming et al. (2015) Increased COUP-TFII expression in adult hearts induces mitochondrial dysfunction resulting in heart failure. Nat Commun 6:8245
Han, Sang Jun; Jung, Sung Yun; Wu, San-Pin et al. (2015) Estrogen Receptor ? Modulates Apoptosis Complexes and the Inflammasome to Drive the Pathogenesis of Endometriosis. Cell 163:960-74
Tang, Ke; Tsai, Sophia Y; Tsai, Ming-Jer (2015) COUP-TFs and eye development. Biochim Biophys Acta 1849:201-9
Mansuy-Aubert, Virginie; Gautron, Laurent; Lee, Syann et al. (2015) Loss of the liver X receptor LXR?/? in peripheral sensory neurons modifies energy expenditure. Elife 4:
Tseng, Hsiu-Ting; Park, Young Joo; Lee, Yoon Kwang et al. (2015) The orphan nuclear receptor small heterodimer partner is required for thiazolidinedione effects in leptin-deficient mice. J Biomed Sci 22:30
Kida, Yasuyuki S; Kawamura, Teruhisa; Wei, Zong et al. (2015) ERRs Mediate a Metabolic Switch Required for Somatic Cell Reprogramming to Pluripotency. Cell Stem Cell 16:547-55

Showing the most recent 10 out of 214 publications