Abstract

The Administrative Core ofthe proposed U19 Center will be responsible for centralized management of the scientific, organizational, financial, contractual, and communication requirements ofthe Center, including handling meeting coordination and ensuring dissemination of information across and between Center projects. The Administrative Core oversight of the Center's projects and Cores will ensure that Center activities synergize and that discoveries are coherently and systematically communicated to scientists within the Center, to the Consortium members, and to the public through presentation at local, national, and international conferences. Dr. Timothy Fennell will serve as Center Director and will have overall responsibility for the Center's administration, including coordinating meetings and symposia, coordinating reports and manuscripts, and monitoring project timelines and budgets. Center support will be provided by the existing RTI International (RTI) infrastructure (i.e., contracts, finance, and facilities). Dr. Fennell will be assisted by Dr. Kenneth Rehder, who reports directly to Dr. Jennie Hunter-Cevera, RTI's Executive Vice President (EVP) for Corporate Development and EVP of Discovery and Analytical Sciences.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Research Program--Cooperative Agreements (U19)
Project #
5U19ES019525-04
Application #
8464712
Study Section
Special Emphasis Panel (ZES1-SET-V)
Project Start
Project End
Budget Start
2013-05-01
Budget End
2014-04-30
Support Year
4
Fiscal Year
2013
Total Cost
$142,344
Indirect Cost
$79,172

  Institution

Name
Research Triangle Institute
Department
Type
DUNS #
004868105
City
Research Triangle
State
NC
Country
United States
Zip Code
27709

  Publications

Vidanapathirana, A K; Thompson, L C; Herco, M et al. (2018) Acute intravenous exposure to silver nanoparticles during pregnancy induces particle size and vehicle dependent changes in vascular tissue contractility in Sprague Dawley rats. Reprod Toxicol 75:10-22
Thompson, Leslie C; Sheehan, Nicole L; Walters, Dianne M et al. (2018) Airway Exposure to Modified Multi-walled Carbon Nanotubes Perturbs Cardiovascular Adenosinergic Signaling in Mice. Cardiovasc Toxicol :
Holland, Nathan A; Fraiser, Chad R; Sloan 3rd, Ruben C et al. (2017) Ultrafine Particulate Matter Increases Cardiac Ischemia/Reperfusion Injury via Mitochondrial Permeability Transition Pore. Cardiovasc Toxicol 17:441-450
Fennell, Timothy R; Mortensen, Ninell P; Black, Sherry R et al. (2017) Disposition of intravenously or orally administered silver nanoparticles in pregnant rats and the effect on the biochemical profile in urine. J Appl Toxicol 37:530-544
Thompson, Leslie C; Holland, Nathan A; Snyder, Ryan J et al. (2016) Pulmonary instillation of MWCNT increases lung permeability, decreases gp130 expression in the lungs, and initiates cardiovascular IL-6 transsignaling. Am J Physiol Lung Cell Mol Physiol 310:L142-54
Holland, Nathan A; Thompson, Leslie C; Vidanapathirana, Achini K et al. (2016) Impact of pulmonary exposure to gold core silver nanoparticles of different size and capping agents on cardiovascular injury. Part Fibre Toxicol 13:48
Anderson, Donald S; Patchin, Esther S; Silva, Rona M et al. (2015) Influence of particle size on persistence and clearance of aerosolized silver nanoparticles in the rat lung. Toxicol Sci 144:366-81
Shannahan, Jonathan H; Podila, Ramakrishna; Brown, Jared M (2015) A hyperspectral and toxicological analysis of protein corona impact on silver nanoparticle properties, intracellular modifications, and macrophage activation. Int J Nanomedicine 10:6509-21
Snyder, Rodney W; Fennell, Timothy R; Wingard, Christopher J et al. (2015) Distribution and biomarker of carbon-14 labeled fullerene C60 ([(14) C(U)]C60 ) in pregnant and lactating rats and their offspring after maternal intravenous exposure. J Appl Toxicol 35:1438-51
Aldossari, Abdullah A; Shannahan, Jonathan H; Podila, Ramakrishna et al. (2015) Influence of physicochemical properties of silver nanoparticles on mast cell activation and degranulation. Toxicol In Vitro 29:195-203

Showing the most recent 10 out of 27 publications