The overall purpose of the Admlnistrafive Core is to ensure scientific, organizational and operational excellence ofthe Program and its ability to meet scientific milestones and objectives ofthe NIEHS. The Core will be responsible for overall organizational structure, administrative activities and fiscal responsibilities of the PNNL's Program for the Toxicity of Engineered Nanoniaterials, and will ensure all research is conducted with integrity and with appropriate environmental, safety and health considerations and planning. These responsibilities will be accomplished by the following Aims: 1) Provide a management and admlnistrative support structure for decision-making processes, planning of research activities, and efficient management of program funds, and resource allocation with the Program; 2) Promote cross-disciplinary interactions and coordination among the research projects and the research core within the Program, including material synthesis and materials characterization; 3) Coordinate statistical analysis and modeling of experimental data across research projects and the research core within the Program;and 4) Ensure effecfive liaison with NIEHS and the broader NIEHS nanotoxicology research consortium. The Admlnistrafive Core will also provide oversight and prioritization of biostatistical resources and activities needed for data integration across projects, biological systems, and to maintain focus of the overall Program goals of developing novel approaches for hazard identificafion and risk assessment for engineered nanomaterials.

National Institute of Health (NIH)
National Institute of Environmental Health Sciences (NIEHS)
Research Program--Cooperative Agreements (U19)
Project #
Application #
Study Section
Special Emphasis Panel (ZES1-SET-V)
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Battelle Pacific Northwest Laboratories
United States
Zip Code
Wang, Yung-Chen; Engelhard, Mark H; Baer, Donald R et al. (2016) Quantifying the Impact of Nanoparticle Coatings and Nonuniformities on XPS Analysis: Gold/Silver Core-Shell Nanoparticles. Anal Chem 88:3917-25
Holland, Nathan A; Thompson, Leslie C; Vidanapathirana, Achini K et al. (2016) Impact of pulmonary exposure to gold core silver nanoparticles of different size and capping agents on cardiovascular injury. Part Fibre Toxicol 13:48
Duan, Jicheng; Kodali, Vamsi K; Gaffrey, Matthew J et al. (2016) Quantitative Profiling of Protein S-Glutathionylation Reveals Redox-Dependent Regulation of Macrophage Function during Nanoparticle-Induced Oxidative Stress. ACS Nano 10:524-38
Baer, Donald R; Wang, Yung-Cheng; Castner, David G (2016) Use of XPS to Quantify Thickness of Coatings on Nanoparticles. Micros Today 24:40-45
Scoville, David K; White, Collin C; Botta, Dianne et al. (2015) Susceptibility to quantum dot induced lung inflammation differs widely among the Collaborative Cross founder mouse strains. Toxicol Appl Pharmacol 289:240-50
Szymanski, Craig J; Munusamy, Prabhakaran; Mihai, Cosmin et al. (2015) Shifts in oxidation states of cerium oxide nanoparticles detected inside intact hydrated cells and organelles. Biomaterials 62:147-54
Munusamy, Prabhakaran; Wang, Chongmin; Engelhard, Mark H et al. (2015) Comparison of 20 nm silver nanoparticles synthesized with and without a gold core: Structure, dissolution in cell culture media, and biological impact on macrophages. Biointerphases 10:031003
Holland, N A; Becak, D P; Shannahan, Jonathan H et al. (2015) Cardiac Ischemia Reperfusion Injury Following Instillation of 20 nm Citrate-capped Nanosilver. J Nanomed Nanotechnol 6:
Teeguarden, Justin G; Mikheev, Vladimir B; Minard, Kevin R et al. (2014) Comparative iron oxide nanoparticle cellular dosimetry and response in mice by the inhalation and liquid cell culture exposure routes. Part Fibre Toxicol 11:46
Cohen, Joel M; Teeguarden, Justin G; Demokritou, Philip (2014) An integrated approach for the in vitro dosimetry of engineered nanomaterials. Part Fibre Toxicol 11:20

Showing the most recent 10 out of 26 publications