The overall purpose of the Admlnistrafive Core is to ensure scientific, organizational and operational excellence ofthe Program and its ability to meet scientific milestones and objectives ofthe NIEHS. The Core will be responsible for overall organizational structure, administrative activities and fiscal responsibilities of the PNNL's Program for the Toxicity of Engineered Nanoniaterials, and will ensure all research is conducted with integrity and with appropriate environmental, safety and health considerations and planning. These responsibilities will be accomplished by the following Aims: 1) Provide a management and admlnistrative support structure for decision-making processes, planning of research activities, and efficient management of program funds, and resource allocation with the Program; 2) Promote cross-disciplinary interactions and coordination among the research projects and the research core within the Program, including material synthesis and materials characterization; 3) Coordinate statistical analysis and modeling of experimental data across research projects and the research core within the Program;and 4) Ensure effecfive liaison with NIEHS and the broader NIEHS nanotoxicology research consortium. The Admlnistrafive Core will also provide oversight and prioritization of biostatistical resources and activities needed for data integration across projects, biological systems, and to maintain focus of the overall Program goals of developing novel approaches for hazard identificafion and risk assessment for engineered nanomaterials.

National Institute of Health (NIH)
National Institute of Environmental Health Sciences (NIEHS)
Research Program--Cooperative Agreements (U19)
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Special Emphasis Panel (ZES1-SET-V)
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Battelle Pacific Northwest Laboratories
United States
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Larson, Jeremy K; Carvan 3rd, Michael J; Teeguarden, Justin G et al. (2014) Low-dose gold nanoparticles exert subtle endocrine-modulating effects on the ovarian steroidogenic pathway ex vivo independent of oxidative stress. Nanotoxicology 8:856-66
Sharma, Gaurav; Kodali, Vamsi; Gaffrey, Matthew et al. (2014) Iron oxide nanoparticle agglomeration influences dose rates and modulates oxidative stress-mediated dose-response profiles in vitro. Nanotoxicology 8:663-75
Cohen, Joel M; Teeguarden, Justin G; Demokritou, Philip (2014) An integrated approach for the in vitro dosimetry of engineered nanomaterials. Part Fibre Toxicol 11:20
Minard, Kevin R; Littke, Matthew H; Wang, Wei et al. (2013) Magnetic particle detection (MPD) for in-vitro dosimetry. Biosens Bioelectron 43:88-93
Kodali, Vamsi; Littke, Matthew H; Tilton, Susan C et al. (2013) Dysregulation of macrophage activation profiles by engineered nanoparticles. ACS Nano 7:6997-7010
Techane, Sirnegeda; Baer, Donald R; Castner, David G (2011) Simulation and modeling of self-assembled monolayers of carboxylic acid thiols on flat and nanoparticle gold surfaces. Anal Chem 83:6704-12
Zhang, Haizhen; Burnum, Kristin E; Luna, Maria L et al. (2011) Quantitative proteomics analysis of adsorbed plasma proteins classifies nanoparticles with different surface properties and size. Proteomics 11:4569-77