This application requests five years of continued support for a collaborative, multi-site, interdisciplinary program of research on the neurobiology and genetics of autism and related conditions. In this program of research the investigators propose to study molecular and family genetic factors, brain-behavior relationships, and aspects of developmental course of autism and related conditions. They also propose continued collaboration with colleagues in the CPEA on a number of network-wide collaborative projects. Goals of this program of research includes a) localization of genes in autism through a continued and refined systematic genome search and candidate gene analysis, b) better definition of endophenotypes in autism through analysis of neuropsychological, social, cognitive, and psychiatric profiles of first degree relatives, c) clarification of the neuroanatomical basis of autism through neuroimaging, and 4) examination of issues of stability of phenotypes of autism and prognostic factors through the study longitudinally of cohorts of children with autism and related conditions. In the competitive renewal the investigators seek continued support for four projects and three core resources. Projects include: I) molecular genetics of autism and related conditions, II) family genetics, III) longitudinal studies, and IV) neuroimaging studies. Three core research resources include A) administration and patient recruitment, B) assessment and diagnosis, and C) data management and statistics. This program project builds on the network of existing collaborations and makes use of important resources at each site.

National Institute of Health (NIH)
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Research Program--Cooperative Agreements (U19)
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Application #
Study Section
Special Emphasis Panel (ZHD1-MRG-C (10))
Program Officer
Kau, Alice S
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Yale University
Schools of Medicine
New Haven
United States
Zip Code
Dickie, Erin W; Ameis, Stephanie H; Shahab, Saba et al. (2018) Personalized Intrinsic Network Topography Mapping and Functional Connectivity Deficits in Autism Spectrum Disorder. Biol Psychiatry 84:278-286
Bishop, Somer L; Thurm, Audrey; Farmer, Cristan et al. (2016) Autism Spectrum Disorder, Intellectual Disability, and Delayed Walking. Pediatrics 137:e20152959
Nebel, Mary Beth; Eloyan, Ani; Nettles, Carrie A et al. (2016) Intrinsic Visual-Motor Synchrony Correlates With Social Deficits in Autism. Biol Psychiatry 79:633-41
Bishop, Somer L; Farmer, Cristan; Thurm, Audrey (2015) Measurement of nonverbal IQ in autism spectrum disorder: scores in young adulthood compared to early childhood. J Autism Dev Disord 45:966-74
Wiggins, Jillian Lee; Swartz, Johnna R; Martin, Donna M et al. (2014) Serotonin transporter genotype impacts amygdala habituation in youth with autism spectrum disorders. Soc Cogn Affect Neurosci 9:832-8
Anderson, Deborah K; Liang, Jessie W; Lord, Catherine (2014) Predicting young adult outcome among more and less cognitively able individuals with autism spectrum disorders. J Child Psychol Psychiatry 55:485-94
Di Martino, A; Yan, C-G; Li, Q et al. (2014) The autism brain imaging data exchange: towards a large-scale evaluation of the intrinsic brain architecture in autism. Mol Psychiatry 19:659-67
MacDonald, Megan; Lord, Catherine; Ulrich, Dale A (2014) Motor skills and calibrated autism severity in young children with autism spectrum disorder. Adapt Phys Activ Q 31:95-105
Alaerts, Kaat; Woolley, Daniel G; Steyaert, Jean et al. (2014) Underconnectivity of the superior temporal sulcus predicts emotion recognition deficits in autism. Soc Cogn Affect Neurosci 9:1589-600
Grzadzinski, Rebecca L; Luyster, Rhiannon; Spencer, Amelia Gunn et al. (2014) Attachment in young children with autism spectrum disorders: an examination of separation and reunion behaviors with both mothers and fathers. Autism 18:85-96

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