Despite many advances in the diagnosis and treatment of cardiovascular disease (CVD) over the past several decades, it remains the leading cause of death and disability in the US and is one of the fastest rising causes of morbidity and mortality globally. This highlights the importance of ascertainment of contemporary and robust data on CVD epidemiology, use and consequences of CVD therapies, and longitudinal outcomes. The HMO Research Network is a consortium of 15 not-for-profit health plans geographically distributed throughout the U.S. with integrated research divisions committed to public domain research that advances population health through its work among its >11 million health plan members. This community-based network provides a unique opportunity to fill key knowledge gaps related to CVD identified by the National Heart, Lung and Blood Institute in RFA-HL-07-011, """"""""Cardiovascular Research Network (CVRN) in Community-Based Care."""""""" Therefore, the overall aims of our proposal are to:
Aim 1. To establish a collaborative Cardiovascular Research Network (CVRN) among 14 member plans of the HMO Research Network to create a unique national resource that leverages the network's cardiovascular expertise, diverse community-based study populations, and rich electronic data systems.
Aim 2. To leverage the HMO Research Network CVRN to conduct three core research projects that demonstrate the network's capability to provide insights into trends in cardiovascular disease, risk factors, and outcomes;identification of prognostic factors;and evaluation and improvement of management and associated clinical outcomes of cardiovascular conditions. The core research projects will target hypertension control, quality of care and outcomes of warfarin therapy for atrial fibrillation and venous thromboembolism, and the use and outcomes of implantable cardioverter defibrillators.
Aim 3. To implement an effective model structure within the HMO Research Network CVRN to rapidly respond to emerging cardiovascular research questions and to facilitate productive external collaborations that maximize the value and productivity of the CVRN. Section A: Overall Program Review

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Program--Cooperative Agreements (U19)
Project #
5U19HL091179-05
Application #
8098123
Study Section
Special Emphasis Panel (ZHL1-CSR-Z (S2))
Program Officer
Wells, Barbara L
Project Start
2007-09-28
Project End
2013-12-31
Budget Start
2011-07-01
Budget End
2013-12-31
Support Year
5
Fiscal Year
2011
Total Cost
$1,399,866
Indirect Cost
Name
Kaiser Foundation Research Institute
Department
Type
DUNS #
150829349
City
Oakland
State
CA
Country
United States
Zip Code
94612
Reynolds, Kristi; Go, Alan S; Leong, Thomas K et al. (2017) Trends in Incidence of Hospitalized Acute Myocardial Infarction in the Cardiovascular Research Network (CVRN). Am J Med 130:317-327
Ashburner, Jeffrey M; Go, Alan S; Chang, Yuchiao et al. (2017) Influence of Competing Risks on Estimating the Expected Benefit of Warfarin in Individuals with Atrial Fibrillation Not Currently Taking Anticoagulants: The Anticoagulation and Risk Factors in Atrial Fibrillation Study. J Am Geriatr Soc 65:35-41
Gurwitz, Jerry H; Magid, David J; Smith, David H et al. (2017) Treatment Effectiveness in Heart Failure with Comorbidity: Lung Disease and Kidney Disease. J Am Geriatr Soc 65:2610-2618
Bansal, Nisha; Szpiro, Adam; Masoudi, Frederick et al. (2017) Kidney function and appropriateness of device therapies in adults with implantable cardioverter defibrillators. Heart 103:529-537
McGrath, Emer R; Go, Alan S; Chang, Yuchiao et al. (2017) Use of Oral Anticoagulant Therapy in Older Adults with Atrial Fibrillation After Acute Ischemic Stroke. J Am Geriatr Soc 65:241-248
Ashburner, Jeffrey M; Go, Alan S; Chang, Yuchiao et al. (2016) Effect of Diabetes and Glycemic Control onĀ Ischemic Stroke Risk in AF Patients: ATRIA Study. J Am Coll Cardiol 67:239-47
Quinn, Gene R; Singer, Daniel E; Chang, Yuchiao et al. (2016) How Well Do Stroke Risk Scores Predict Hemorrhage in Patients With Atrial Fibrillation? Am J Cardiol 118:697-9
Lee, Keane K; Yang, Jingrong; Hernandez, Adrian F et al. (2016) Post-discharge Follow-up Characteristics Associated With 30-Day Readmission After Heart Failure Hospitalization. Med Care 54:365-72
Delate, Thomas; Hsiao, Wendy; Kim, Benjamin et al. (2016) Assessment of algorithms to identify patients with thrombophilia following venous thromboembolism. Thromb Res 137:97-102
Samuelson, Bethany; Go, Alan S; Sung, Sue Hee et al. (2016) Initial management and outcomes after superficial thrombophlebitis: The Cardiovascular Research Network Venous Thromboembolism study. J Hosp Med 11:432-4

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