Increasing health care costs and disturbing gaps in quality of care make it imperative to identify and implement the most effective and efficient health care services. This need for effectiveness research to guide practice and policy is especially pressing in mental health. The arrival rate of new mental health treatments far exceeds our ability to compare them in traditional clinical trials. Meeting this demand for timely and relevant evidence will require transformation of research to increase generalizability while reducing research time and expense. New infrastructure and innovative research methods will be necessary to accomplish that transformation. We propose to develop a Mental Health Research Network (MHRN) including nine established public domain research centers based in integrated not-for-profit health systems. These systems provide care to a diverse population of 10 million people in 11 states, and they share rich and compatible data resources to support a range of effectiveness research. Diversity of member demographics, insurance coverage, and organization of health services make this network an ideal environment for studying variation in care, comparing effectiveness and cost of treatments across practice environments, and studying dissemination and health policies. Participating research centers are experienced in a wide range of clinical areas and research methods. Three years of funding will support development of a core infrastructure for collaborative effectiveness research in mental health and completion of 4 research projects that leverage that infrastructure in specific clinical areas. The 4 research projects include the following: 1) An observational study of practice variation in high- and low-value care for mood disorders, 2) A pilot effectiveness trial of behavioral activation therapy for perinatal depression, 3) A geographically and ethnically diverse autism registry for effectiveness studies, and 4) Longitudinal analysis of SSRI warnings and suicidality in youth. Our long-term objectives are to expand the MHRN to include additional health systems and external investigators, to conduct multi-site observational and experimental studies of comparative effectiveness, to develop and evaluate methods for dissemination and implementation, and to become a national resource of research methods and effectiveness evidence for researchers, patients, providers and healthcare leaders.

Public Health Relevance

We propose to develop a Mental Health Research Network (MHRN) including 9 established research centers based in integrated health care systems. The MHRN will complement traditional clinical research by taking advantage of large potential samples of patients, diverse patient care settings, access to large provider groups, and integrated data systems to conduct rapid and efficient effectiveness trials in mental health. The ultimate goal is to improve the public health impact of mental health research on the US population.

National Institute of Health (NIH)
National Institute of Mental Health (NIMH)
Research Program--Cooperative Agreements (U19)
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Special Emphasis Panel (ZMH1-ERB-B (02))
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Chambers, David A
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Group Health Cooperative
United States
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Ahmedani, Brian K; Vannoy, Steven (2014) National pathways for suicide prevention and health services research. Am J Prev Med 47:S222-8
Ahmedani, Brian K; Simon, Gregory E; Stewart, Christine et al. (2014) Health care contacts in the year before suicide death. J Gen Intern Med 29:870-7
Lu, Christine Y; Zhang, Fang; Lakoma, Matthew D et al. (2014) Changes in antidepressant use by young people and suicidal behavior after FDA warnings and media coverage: quasi-experimental study. BMJ 348:g3596
Lu, Christine Y; Stewart, Christine; Ahmed, Ameena T et al. (2014) How complete are E-codes in commercial plan claims databases? Pharmacoepidemiol Drug Saf 23:218-20
Simon, Gregory E; Stewart, Christine; Beck, Arne et al. (2014) National prevalence of receipt of antidepressant prescriptions by persons without a psychiatric diagnosis. Psychiatr Serv 65:944-6
Penfold, Robert B; Stewart, Christine; Hunkeler, Enid M et al. (2013) Use of antipsychotic medications in pediatric populations: what do the data say? Curr Psychiatry Rep 15:426
Simon, Gregory E; Peterson, Do; Hubbard, Rebecca (2013) Is treatment adherence consistent across time, across different treatments and across diagnoses? Gen Hosp Psychiatry 35:195-201
Hacker, Karen; Penfold, Robert; Zhang, Fang et al. (2012) Impact of electronic health record transition on behavioral health screening in a large pediatric practice. Psychiatr Serv 63:256-61
Ahmed, Ameena T; Blair, Thomas R W; McIntyre, Roger S (2011) Surgical treatment of morbid obesity among patients with bipolar disorder: a research agenda. Adv Ther 28:389-400