Introduction and Overview Our objective in this study is to evaluate the possible unintended consequences ofthe FDA decision to issue a warning regarding the prescribing of SSRIs to children and adolescents and require a BBW on antidepressant labels. Depression is prevalent among youth in the US and is a risk factor for suicide.(21) Thus, it is of critical importance that the public health implications of possible decreases in antidepressant treatment rates be fully understood. While much research has been conducted in this area, suboptimal study design, absence of long-term trend data, and/or lack of statistical power have left important questions about the effects ofthe warnings on suicidality unanswered. Below we review the important studies to date and highlight how our proposed research will fill gaps in our understanding ofthe relationships among FDA warnings (and associated media reports), antidepressant treatment in youth, and risk of suicidal behavior.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Research Program--Cooperative Agreements (U19)
Project #
5U19MH092201-03
Application #
8381078
Study Section
Special Emphasis Panel (ZMH1-ERB-B)
Project Start
Project End
2014-07-31
Budget Start
2012-08-01
Budget End
2013-07-31
Support Year
3
Fiscal Year
2012
Total Cost
$121,742
Indirect Cost
$55,597
Name
Group Health Cooperative
Department
Type
DUNS #
078198520
City
Seattle
State
WA
Country
United States
Zip Code
98101
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Owen-Smith, Ashli; Stewart, Christine; Green, Carla et al. (2016) Adherence to common cardiovascular medications in patients with schizophrenia vs. patients without psychiatric illness. Gen Hosp Psychiatry 38:9-14
Scherrer, Jeffrey F; Salas, Joanne; Copeland, Laurel A et al. (2016) Prescription Opioid Duration, Dose, and Increased Risk of Depression in 3 Large Patient Populations. Ann Fam Med 14:54-62
Cummings, Janet R; Lynch, Frances L; Rust, Kristal C et al. (2016) Health Services Utilization Among Children With and Without Autism Spectrum Disorders. J Autism Dev Disord 46:910-20
Coleman, Karen J; Stewart, Christine; Waitzfelder, Beth E et al. (2016) Racial-Ethnic Differences in Psychiatric Diagnoses and Treatment Across 11 Health Care Systems in the Mental Health Research Network. Psychiatr Serv 67:749-57
Simon, Gregory E; Specht, Cynthia; Doederlein, Allen (2016) Coping With Suicidal Thoughts: A Survey of Personal Experience. Psychiatr Serv 67:1026-9
Rossom, Rebecca C; Simon, Gregory E; Beck, Arne et al. (2016) Facilitating Action for Suicide Prevention by Learning Health Care Systems. Psychiatr Serv 67:830-2
Hacker, Karen A; Penfold, Robert B; Arsenault, Lisa N et al. (2015) Effect of Pediatric Behavioral Health Screening and Colocated Services on Ambulatory and Inpatient Utilization. Psychiatr Serv 66:1141-8
Ahmedani, Brian K; Stewart, Christine; Simon, Gregory E et al. (2015) Racial/Ethnic differences in health care visits made before suicide attempt across the United States. Med Care 53:430-5
Coleman, Karen J; Lutsky, Marta A; Yau, Vincent et al. (2015) Validation of Autism Spectrum Disorder Diagnoses in Large Healthcare Systems with Electronic Medical Records. J Autism Dev Disord 45:1989-96

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