Abstract

Introduction and Overview Our objective in this study is to evaluate the possible unintended consequences ofthe FDA decision to issue a warning regarding the prescribing of SSRIs to children and adolescents and require a BBW on antidepressant labels. Depression is prevalent among youth in the US and is a risk factor for suicide.(21) Thus, it is of critical importance that the public health implications of possible decreases in antidepressant treatment rates be fully understood. While much research has been conducted in this area, suboptimal study design, absence of long-term trend data, and/or lack of statistical power have left important questions about the effects ofthe warnings on suicidality unanswered. Below we review the important studies to date and highlight how our proposed research will fill gaps in our understanding ofthe relationships among FDA warnings (and associated media reports), antidepressant treatment in youth, and risk of suicidal behavior.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Research Program--Cooperative Agreements (U19)
Project #
5U19MH092201-03
Application #
8381078
Study Section
Special Emphasis Panel (ZMH1-ERB-B)
Project Start
Project End
2014-07-31
Budget Start
2012-08-01
Budget End
2013-07-31
Support Year
3
Fiscal Year
2012
Total Cost
$121,742
Indirect Cost
$55,597

  Institution

Name
Group Health Cooperative
Department
Type
DUNS #
078198520
City
Seattle
State
WA
Country
United States
Zip Code
98101

  Publications

Rossom, Rebecca C; Simon, Greg E; Coleman, Karen J et al. (2018) Are wishes for death or suicidal ideation symptoms of depression in older adults? Aging Ment Health :1-7
Lu, Christine Y; Simon, Gregory; Soumerai, Stephen B et al. (2018) Counter-Point: Early Warning Systems Are Imperfect, but Essential. Med Care 56:382-383
Lu, Christine Y; Simon, Gregory; Soumerai, Stephen B (2018) Counter-Point: Staying Honest When Policy Changes Backfire. Med Care 56:384-390
Waitzfelder, Beth; Stewart, Christine; Coleman, Karen J et al. (2018) Treatment Initiation for New Episodes of Depression in Primary Care Settings. J Gen Intern Med 33:1283-1291
Coleman, Karen J; Johnson, Eric; Ahmedani, Brian K et al. (2018) Predicting Suicide Attempts for Racial and Ethnic Groups of Patients During Routine Clinical Care. Suicide Life Threat Behav :
Lu, Christine Y; Penfold, Robert B; Toh, Sengwee et al. (2018) Near Real-time Surveillance for Consequences of Health Policies Using Sequential Analysis. Med Care 56:365-372
Simon, Gregory E; Johnson, Eric; Lawrence, Jean M et al. (2018) Predicting Suicide Attempts and Suicide Deaths Following Outpatient Visits Using Electronic Health Records. Am J Psychiatry 175:951-960
Dimidjian, Sona; Goodman, Sherryl H; Sherwood, Nancy E et al. (2017) A pragmatic randomized clinical trial of behavioral activation for depressed pregnant women. J Consult Clin Psychol 85:26-36
Rossom, Rebecca C; Coleman, Karen J; Ahmedani, Brian K et al. (2017) Suicidal ideation reported on the PHQ9 and risk of suicidal behavior across age groups. J Affect Disord 215:77-84
Wolk, Courtney Benjamin; Jager-Hyman, Shari; Marcus, Steven C et al. (2017) Developing implementation strategies for firearm safety promotion in paediatric primary care for suicide prevention in two large US health systems: a study protocol for a mixed-methods implementation study. BMJ Open 7:e014407

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