This proposal aims to establish a regional hub for mental health research and training addressing the comorbidity between mental and chronic diseases, aiming to decrease the treatment gap for mental disorders among people with physical disorders in LA &C.
These aims will be achieved through: 1. Development of a research agenda focused on developing an intervention for the identification and treatment of depression among people attending programs for chronic diseases. This intervention will involve two key elements: a) improved recognition and b) improved psycho-social management of depression in diverse health care settings in LA &C. It will be mostly delivered through the use of mobile phones, with minimal assistance from primary care auxiliary nurses, with substantial task-shifting. The main emphasis is on patients helping themselves through using resources that are currently delivered on a one-to-one basis by specialized human resources. The intervention will be tested in primary care clinics in Sao Paulo, Brazil, and in secondary care clinics in Lima, Peru. Pilot studies will take place in Guatemala, Colombia and Ecuador. 2. To build increased mental health research capacity in the region through a research training program delivered by a network involving the University of Sao Paulo in Brazil, the Latin American network for the Global Alliance for Chronic Disease, and Universities of Washington and Bristol. The strategy will include: 1) greater prominence to South-South collaboration;2) focus on a multiplying strategy starting with the strengthening of a solid research hub and gradual expansion to other sub-centers in a large mutually supportive research network;and 3) more efficient methods of delivering training with improved accessibility. The capacity building component prioritizes training in research methodologies that can generate sound evidence on the best strategies to reduce this gap, allowing 'hands-on'training for researchers. In both components due importance is given to issues related to scaling up and policy making, including the creation of a highly qualified advisory board and consultation with a range of stakeholders throughout the life of the project.

Public Health Relevance

Depression is highly prevalent in LA &C and is now considered the second most important contributor to the global health burden in the region. Only small proportions of those depressed are recognized and receive treatment in LA &C. There is substantial co-morbidity between depression and chronic physical conditions, and outcome of both conditions is impaired when there is co-morbidity. Evidence on efficient, low-cost interventions is urgently needed to guide reduce the mental health treatment gap.

National Institute of Health (NIH)
National Institute of Mental Health (NIMH)
Research Program--Cooperative Agreements (U19)
Project #
Application #
Study Section
Special Emphasis Panel (ZMH1-ERB-B (04))
Program Officer
Pringle, Beverly
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Fundacao Faculdade de Medicina
Sao Paulo
Zip Code
Price, LeShawndra N (2018) Building global mental health research capacity: the collaborative hubs for international research on mental health. Glob Ment Health (Camb) 5:e34
Ruiz-Alejos, Andrea; Carrillo-Larco, Rodrigo M; Miranda, J Jaime et al. (2018) Addressing the impact of urban exposure on the incidence of type 2 diabetes mellitus: The PERU MIGRANT Study. Sci Rep 8:5512
Miranda, J J; Moscoso, M G; Toyama, M et al. (2018) Role of mHealth in overcoming the occurrence of post-stroke depression. Acta Neurol Scand 137:12-19
Benziger, Catherine P; Zavala-Loayza, José Alfredo; Bernabe-Ortiz, Antonio et al. (2018) Low prevalence of ideal cardiovascular health in Peru. Heart 104:1251-1256
Pham, Luu V; Miele, Catherine H; Schwartz, Noah G et al. (2017) Cardiometabolic correlates of sleep disordered breathing in Andean highlanders. Eur Respir J 49:
Bonini, B B; Araya, R; Quayle, J et al. (2017) LATIN-MH: a model for building research capacity within Latin America. Glob Ment Health (Camb) 4:e2
Jimenez, M Michelle; Bui, Anthony L; Mantilla, Eduardo et al. (2017) Human resources for health in Peru: recent trends (2007-2013) in the labour market for physicians, nurses and midwives. Hum Resour Health 15:69
Lazo-Porras, Maria; Bernabe-Ortiz, Antonio; Quispe, Renato et al. (2017) Urbanization, mainly rurality, but not altitude is associated with dyslipidemia profiles. J Clin Lipidol 11:1212-1222.e4
Miranda, J Jaime; Diez-Canseco, Francisco; Araya, Ricardo et al. (2017) Transitioning mental health into primary care. Lancet Psychiatry 4:90-92
Lazo-Porras, Maria; Ortiz-Soriano, Victor; Moscoso-Porras, Miguel et al. (2017) Cognitive impairment and hypertension in older adults living in extreme poverty: a cross-sectional study in Peru. BMC Geriatr 17:250

Showing the most recent 10 out of 21 publications