The University of the South Pacific (USP) is the major educational vehicle serving 12 lower income island nations in the South Pacific region. The Center for Drug Discovery and Conservation (CDDC) at the USP was founded as part of this ICBG program and provides advanced graduate student training in diverse subjects including marine natural products chemistry, microbiology, drug discovery, and marine conservation. The CDDC is the central resource through which all ICBG activities will occur. The CDDC will continue to facilitate interactions with local and government officials and subsequent collection activities. CDDC personnel will continue to provide local field expertise and preliminary taxonomic analyses of algal and invertebrate samples. Major research activities will include the participation in ecology-guided natural product discovery in collaboration with other associate programs. Our researchers will perform bioassay-guided fractionation of prioritized algal and invertebrate extracts and assist with the structure elucidate of active compounds. The CDDC will take an increased role in the marine microbiology program, leveraging valuable experience gained from prior ICBG funding to assemble a diverse and chemically rich collection of cultured marine bacteria. Extracts generated from these bacteria will serve as the source material for the microbial drug discovery efforts. Technology transfer and training are important components of this program and include personnel visiting Scripps and Georgia Institute of Technology for advanced training in natural products chemistry and marine microbiology, respectively. Training and scientific exchange will also occur during regular visits by associate program participants to the USP and during taxonomy and benefit sharing workshops organized by the CDDC. The CDDC will work with marine ecologists to develop more effective strategies for reef conservation and to expand the Locally-Managed Marine Area (LMMA) program, which has proven to be a highly effective method to bring village-level awareness to the importance of conservation and the maintenance of healthy coral reefs. A long-term goal of this program is to further enhance the capabilities of the CDDC as vibrant center for conservation and drug discovery and to ensure that it will continue to provide these important functions long after ICBG funding has ended.

Agency
National Institute of Health (NIH)
Institute
Fogarty International Center (FIC)
Type
Research Program--Cooperative Agreements (U19)
Project #
2U19TW007401-10
Application #
8785215
Study Section
Special Emphasis Panel (ZRG1-BCMB-H (50))
Project Start
Project End
Budget Start
2014-08-28
Budget End
2015-07-31
Support Year
10
Fiscal Year
2014
Total Cost
$187,040
Indirect Cost
$67,040
Name
Georgia Institute of Technology
Department
Type
DUNS #
097394084
City
Atlanta
State
GA
Country
United States
Zip Code
30332
Brooker, Rohan M; Brandl, Simon J; Dixson, Danielle L (2016) Cryptic effects of habitat declines: coral-associated fishes avoid coral-seaweed interactions due to visual and chemical cues. Sci Rep 6:18842
Dell, Claire L A; Longo, Guilherme O; Hay, Mark E (2016) Positive Feedbacks Enhance Macroalgal Resilience on Degraded Coral Reefs. PLoS One 11:e0155049
Jensen, Paul R (2016) Natural Products and the Gene Cluster Revolution. Trends Microbiol 24:968-977
Tang, Xiaoyu; Li, Jie; Millán-Aguiñaga, Natalie et al. (2015) Identification of Thiotetronic Acid Antibiotic Biosynthetic Pathways by Target-directed Genome Mining. ACS Chem Biol 10:2841-9
Jensen, Paul R; Moore, Bradley S; Fenical, William (2015) The marine actinomycete genus Salinispora: a model organism for secondary metabolite discovery. Nat Prod Rep 32:738-51
Choi, Eun Ju; Nam, Sang-Jip; Paul, Lauren et al. (2015) Previously Uncultured Marine Bacteria Linked to Novel Alkaloid Production. Chem Biol 22:1270-9
Duncan, Katherine R; Crüsemann, Max; Lechner, Anna et al. (2015) Molecular networking and pattern-based genome mining improves discovery of biosynthetic gene clusters and their products from Salinispora species. Chem Biol 22:460-71
Clements, Cody S; Hay, Mark E (2015) Competitors as accomplices: seaweed competitors hide corals from predatory sea stars. Proc Biol Sci 282:
Dixson, Danielle L; Abrego, David; Hay, Mark E (2014) Reef ecology. Chemically mediated behavior of recruiting corals and fishes: a tipping point that may limit reef recovery. Science 345:892-7
Rasher, Douglas B; Hay, Mark E (2014) Competition induces allelopathy but suppresses growth and anti-herbivore defence in a chemically rich seaweed. Proc Biol Sci 281:20132615

Showing the most recent 10 out of 42 publications