This is a competitive renewal for the Administrative Core (AdminC) of the Collaborative Initiative on Fetal Alcohol Spectrum Disorders (CIFASD) in response to RFA-AA-12-005. The AdminC oversees a multidisciplinary, multisite consortium consisting of both basic science and clinical components, with the aim of improving the diagnostic criteria for the range of outcomes following prenatal alcohol exposure. The consortium consists of three cores (AdminC, Dysmorphology, and Informatics), 5 clinical U01s, and 2 basic science UOIs. These projects are structured to be collaborative and interrelated. The AdminC maintains the organizational framework for the CIFASD, managing and supporting the two components and their Steering Committees, and providing support to the Science Advisory Board. Besides its administrative functions, the AdminC is also responsible for two additional components, the Developmental and Educational Components of the CIFASD. The Developmental Component provides a mechanism for the inclusion of new research ideas, potential new sites, and higher risk/higher payoff projects. The Educational Component provides a new mechanism to ensure that consortium findings are widely circulated to the public and other stakeholders in a timely fashion.
The Specific Aims of the AdminC are to: 1) Provide scientific and administrative leadership and oversight, ensuring that CIFASD investigators adhere to its goals and mission, as well as assisting and coordinating interactions between the various projects. Function as the main liaison to NIAAA regarding the CIFASD;2) Facilitate communication between the various projects by maintaining the CIFASD web site, scheduling monthly conference calls, convening the biannual meetings of the Steering Committees, and preparing and distributing annual progress reports;3) Provide assistance with data collection and distribution by working with the Informatics Core. Work with the Informatics Core to develop online interactive capacity among CIFASD investigators, and make most of these databases available to outside, interested scientists;4) Assist the Science Advisory Board and the Steering Committees in their annual evaluations of progress for each of the projects. In conjunction with the Steering Committees, it will establish annual priorities and address issues related to allocation of resources;and 5) Administer the Developmental and Educational Components of the CIFASD.

Public Health Relevance

The consequences resulting from prenatal alcohol exposure are wide-ranging and are major public health issues. The goal of the research proposed by the CIFASD is to enhance the diagnosis of fetal alcohol spectrum disorders across the range of outcomes, using a multisite, multidisciplinary consortium consisting of both basic science and clinical projects.

National Institute of Health (NIH)
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Resource-Related Research Projects--Cooperative Agreements (U24)
Project #
Application #
Study Section
Special Emphasis Panel (ZAA1-CC (02))
Program Officer
Dunty, Jr, William
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
San Diego State University
Schools of Arts and Sciences
San Diego
United States
Zip Code
Doyle, Lauren R; Moore, Eileen M; Coles, Claire D et al. (2018) Executive Functioning Correlates With Communication Ability in Youth With Histories of Heavy Prenatal Alcohol Exposure. J Int Neuropsychol Soc 24:1026-1037
Donald, Kirsten A; Hoogenhout, Michelle; du Plooy, Christopher P et al. (2018) Drakenstein Child Health Study (DCHS): investigating determinants of early child development and cognition. BMJ Paediatr Open 2:e000282
Suttie, Michael; Wozniak, Jeffrey R; Parnell, Scott E et al. (2018) Combined Face-Brain Morphology and Associated Neurocognitive Correlates in Fetal Alcohol Spectrum Disorders. Alcohol Clin Exp Res 42:1769-1782
Gross, Lauren A; Moore, Eileen M; Wozniak, Jeffrey R et al. (2018) Neural correlates of verbal memory in youth with heavy prenatal alcohol exposure. Brain Imaging Behav 12:806-822
Charness, Michael E (2018) The adolescent brain cognitive development study external advisory board. Dev Cogn Neurosci 32:155-160
Hendrickson, Timothy J; Mueller, Bryon A; Sowell, Elizabeth R et al. (2018) Two-year cortical trajectories are abnormal in children and adolescents with prenatal alcohol exposure. Dev Cogn Neurosci 30:123-133
Bodnar, Tamara S; Raineki, Charlis; Wertelecki, Wladimir et al. (2018) Altered maternal immune networks are associated with adverse child neurodevelopment: Impact of alcohol consumption during pregnancy. Brain Behav Immun 73:205-215
Dou, Xiaowei; Menkari, Carrie; Mitsuyama, Rei et al. (2018) L1 coupling to ankyrin and the spectrin-actin cytoskeleton modulates ethanol inhibition of L1 adhesion and ethanol teratogenesis. FASEB J 32:1364-1374
Idrus, Nirelia M; Breit, Kristen R; Thomas, Jennifer D (2017) Dietary choline levels modify the effects of prenatal alcohol exposure in rats. Neurotoxicol Teratol 59:43-52
Kable, Julie A; Coles, Claire D; CIFASD (2017) Prefrontal cortical responses in children with prenatal alcohol-related neurodevelopmental impairment: A functional near-infrared spectroscopy study. Clin Neurophysiol 128:2099-2109

Showing the most recent 10 out of 87 publications