In the fourth decade of the HIV epidemic, many questions remain about how alcohol use affects HIV clinical manifestations and how treatments beyond ART might mitigate alcohol-related harms. Such questions about the complex relationship between HIV and alcohol need to be addressed in order to accelerate the development of more effective treatments. The Uganda Russia Boston Alcohol Network for Alcohol Research Collaboration on HIV/AIDS (URBAN ARCH) Consortium will carry out cohort and intervention studies under the leadership of the Administrative Coordinating Core (Admin Core) to address gaps in our understanding about HIV and alcohol. The central goal of the URBAN ARCH Consortium is to examine the consequences of alcohol on HIV disease and to mitigate its harmful effects. To realize this goal, the URBAN ARCH Consortium will incorporate the expertise of researchers in epidemiology, internal medicine, addiction medicine, HIV/AIDS, psychiatry and biostatistics, under the leadership of a Consortium PI who is a leader in the field of HIV and clinical addiction medicine. The Consortium studies will build on three existing HIV- infected cohorts from Boston, Uganda, and Russia with distinctive strengths and well-characterized alcohol consumption patterns. The two international cohorts allow study of clinical issues that would not be possible in the United States, yet have important implications for US HIV-infected populations. The objective of the Admin Core is to ensure that the scientific and programmatic goals of the URBAN ARCH Consortium are achieved with high quality and timeliness. Accordingly, the Admin Core will accomplish the following Specific Aims: Promote a collaborative, integrated approach to research goals; Facilitate constructive communication and creative collaboration between all Consortium components; Coordinate and prioritize access to resources including the URBAN ARCH data and sample repository; Assess components'progress and quality to maximize the scientific impact of the Consortium; Encourage the sharing of data to investigators within and outside the Consortium. The accomplishment of the Admin Core's aims will maximize the overall productivity of the URBAN ARCH Consortium and realize the potential of the outstanding multi-institutional, inter-disciplinary, and international collaborations. In working with all of the Consortium components, the Admin Core will ensure adherence to preplanned aims and support new evolving lines of scientific inquiry consistent with the Consortium's goal.

Public Health Relevance

The URBAN ARCH Consortium will conduct and disseminate interdisciplinary alcohol/HIV research aimed at understanding the consequences of alcohol on HIV disease and advancing clinical approaches to mitigate its harm in the United States and globally. By utilizing distinctive cohorts in the United States and abroad, the Consortium will be uniquely positioned to provide insights about the relationship of alcohol and HIV infection so as to improve clinical and public health outcomes for the associated consequences.

National Institute of Health (NIH)
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Resource-Related Research Projects--Cooperative Agreements (U24)
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Special Emphasis Panel (ZAA1-DD (04))
Program Officer
Wang, Joe
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Boston Medical Center
United States
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Samet, Jeffrey H; Raj, Anita; Cheng, Debbie M et al. (2015) HERMITAGE--a randomized controlled trial to reduce sexually transmitted infections and HIV risk behaviors among HIV-infected Russian drinkers. Addiction 110:80-90
Edelman, E Jennifer; Cheng, Debbie M; Krupitsky, Evgeny M et al. (2015) Heroin Use and HIV Disease Progression: Results from a Pilot Study of a Russian Cohort. AIDS Behav 19:1089-97
Fuster, Daniel; Cheng, Debbie M; Quinn, Emily K et al. (2014) Inflammatory cytokines and mortality in a cohort of HIV-infected adults with alcohol problems. AIDS 28:1059-64
Walley, Alexander Y; Cheng, Debbie M; Coleman, Sharon M et al. (2014) Risk factors for recent nonfatal overdose among HIV-infected Russians who inject drugs. AIDS Care 26:1013-8
Goodness, Tracie M; Palfai, Tibor P; Cheng, Debbie M et al. (2014) Depressive symptoms and antiretroviral therapy (ART) initiation among HIV-infected Russian drinkers. AIDS Behav 18:1085-93
Tsui, Judith I; Cheng, Debbie M; Coleman, Sharon M et al. (2014) Pain is associated with risky drinking over time among HIV-infected persons in St. Petersburg, Russia. Drug Alcohol Depend 144:87-92
Lunze, Karsten; Raj, Anita; Cheng, Debbie M et al. (2014) Punitive policing and associated substance use risks among HIV-positive people in Russia who inject drugs. J Int AIDS Soc 17:19043
Kiriazova, T; Cheng, D M; Coleman, S M et al. (2014) Factors associated with study attrition among HIV-infected risky drinkers in St. Petersburg, Russia. HIV Clin Trials 15:116-25
Urada, L A; Raj, A; Cheng, D M et al. (2013) History of intimate partner violence is associated with sex work but not sexually transmitted infection among HIV-positive female drinkers in Russia. Int J STD AIDS 24:287-92
Tyurina, Arina; Krupitsky, Evgeny; Cheng, Debbie M et al. (2013) Is cannabis use associated with HIV drug and sex risk behaviors among Russian HIV-infected risky drinkers? Drug Alcohol Depend 132:74-80

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