A sound study design, appropriate analytic techniques, and the proper management of data are essential components of a study to ensure that valid inferences will be made. The Biostatistics and Data Management (BDM) Core within the Uganda Russia Boston Alcohol Network for Alcohol Research Collaboration on HIV/AIDS (URBAN ARCH) Consortium will provide statistical and data management leadership in all phases of research including study design, development of data collection instruments, implementation of the study protocols, performance of data analyses, and the preparation of manuscripts. The BDM Core will actively collaborate in the design, conduct, and analyses of clinical research studies with the aim of conducting scientifically rigorous research and providing definitive answers to the important scientific questions described within each project-specific proposal. There are two principal objectives of the BDM Core: to provide active statistical collaboration in the design and analysis of each individual study;and to develop and maintain an integrated, centralized data management system that may be used by all studies within the URBAN ARCH Consortium. To accomplish these goals, the BDM Core will have ongoing collaboration in all aspects of the planning, execution, and evaluation of each of the URBAN ARCH Consortium projects. The BDM Core brings together a highly experienced team of investigators who have collaborated extensively in studies of alcohol use and HIV, and who have a history of international, multi-site collaboration. Within the BDM Core, a close interaction of personnel performing tasks will facilitate procedural consistency and efficiency of Consortium-wide systems. Ultimately, the BDM Core will increase the productivity of the Consortium investigators, ensure the validity and generalizability of the research findings generated from the URBAN ARCH Consortium, and elevate the scientific understanding of alcohol's impact on HIV disease outcomes.

Public Health Relevance

The Biostatistics and Data Management Core will collaborate extensively with URBAN ARCH Consortium investigators in all phases of study, from study inception to the publication of research findings. These activities will contribute to the efforts of each study to examine the consequences of alcohol on HIV disease by increasing the efficiency and productivity of Consortium investigators and ultimately ensuring the scientific integrity of results from the URBAN ARCH Consortium studies.

National Institute of Health (NIH)
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Resource-Related Research Projects--Cooperative Agreements (U24)
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Special Emphasis Panel (ZAA1-DD (04))
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Wang, Joe
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Boston University
Biostatistics & Other Math Sci
Schools of Public Health
United States
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Samet, Jeffrey H; Raj, Anita; Cheng, Debbie M et al. (2015) HERMITAGE--a randomized controlled trial to reduce sexually transmitted infections and HIV risk behaviors among HIV-infected Russian drinkers. Addiction 110:80-90
Edelman, E Jennifer; Cheng, Debbie M; Krupitsky, Evgeny M et al. (2015) Heroin Use and HIV Disease Progression: Results from a Pilot Study of a Russian Cohort. AIDS Behav 19:1089-97
Fuster, Daniel; Cheng, Debbie M; Quinn, Emily K et al. (2014) Inflammatory cytokines and mortality in a cohort of HIV-infected adults with alcohol problems. AIDS 28:1059-64
Walley, Alexander Y; Cheng, Debbie M; Coleman, Sharon M et al. (2014) Risk factors for recent nonfatal overdose among HIV-infected Russians who inject drugs. AIDS Care 26:1013-8
Goodness, Tracie M; Palfai, Tibor P; Cheng, Debbie M et al. (2014) Depressive symptoms and antiretroviral therapy (ART) initiation among HIV-infected Russian drinkers. AIDS Behav 18:1085-93
Tsui, Judith I; Cheng, Debbie M; Coleman, Sharon M et al. (2014) Pain is associated with risky drinking over time among HIV-infected persons in St. Petersburg, Russia. Drug Alcohol Depend 144:87-92
Kiriazova, T; Cheng, D M; Coleman, S M et al. (2014) Factors associated with study attrition among HIV-infected risky drinkers in St. Petersburg, Russia. HIV Clin Trials 15:116-25
Raj, Anita; Kidd, Jeremy D; Cheng, Debbie M et al. (2013) Associations between partner violence perpetration and history of STI among HIV-infected substance using men in Russia. AIDS Care 25:646-51
Urada, L A; Raj, A; Cheng, D M et al. (2013) History of intimate partner violence is associated with sex work but not sexually transmitted infection among HIV-positive female drinkers in Russia. Int J STD AIDS 24:287-92
Tsui, Judith I; Cheng, Debbie M; Coleman, Sharon M et al. (2013) Pain is associated with heroin use over time in HIV-infected Russian drinkers. Addiction 108:1779-87