The overall aim of the NIAAA-funded Consortium to improve OutcoMes in hiv/Aids, Alcohol, Aging, & multi- Substance use (COMpAAAS) is to build and disseminate the evidence needed to optimize care for HIV+ experiencing medical harm from alcohol and related substance use, through coordinated, integrated, and externally validated observational, operations research modeling, and intervention studies. Combining and integrating the complimentary expertise of informatics, biostatistics and epidemiology, we propose a U24 Resource for Informatics and Biostatistics (RIB) to support and inform the other COMpAAAS components. This resource will address the complex challenges required to maximize power and minimize bias in analyses addressing consortium-wide questions. Advanced informatics methods supported include natural language processing (NLP), ontologies, database and clinical decision support, and application of vital data management tools for secure data collection, storage, annotation, retrieval, and integration. Advanced epidemiological and statistical methods include time-updated exposure techniques, multiple imputation, propensity score techniques, measurement error correction, and competing risks regression. Routine, but essential, statistical methods include Cox proportional hazards, logistic and linear regression, goodness of fit diagnostics, and agreement/accuracy metrics (kappa, sensitivity, specificity, etc.). The RIB will further leverage the observational and interventional studies, simulation models, and well-coordinated network of cores and workgroups of COMpAAAS with advanced informatics and biostatistical techniques tailored to the particular challenges of large scale, longitudinal data from multiple sources including electronic health records (EHR), clinical interventions, patient self-report, and tissue repositories.
Our specific aims are to provide 1) statistical and 2) informatics expertise for COMpAAAS to maximize scientific impact. To accomplish this, we will enhance the design, recruitment, and follow-up of intervention studies, support appropriate design and execution of data analyses and cross cohort collaborations, provide advanced statistical methods plus estimates of alcohol patterns for OR modeling and identify sexual/gender minority populations (CHAMP) from VACS survey data. In addition we will enhance the Consortium Web-Based Laboratory (WBL Portal) informatics infrastructure to support ongoing research design, data collection and management, development and testing of interventions such as clinical decision support and eHealth tools and enhance support for the analysis of textual data.

Public Health Relevance

The Resource for Informatics and Biostatistics (RIB) will extend and enhance the research capacities and productivity among investigators at the NIAAA-funded Consortium to improve OutcoMes in hiv/AIDS, Alcohol, Aging, and multi-Substance use (COMpAAAS). This resource will provide Biostatistics and Informatics expertise that will allow investigators to develop techniques tailored to the particular challenges of large scale, longitudinal data from multiple sources including electronic health records (EHR), clinical interventions, patient self-report, and tissue repositories.

Agency
National Institute of Health (NIH)
Institute
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Type
Resource-Related Research Projects--Cooperative Agreements (U24)
Project #
2U24AA022001-05
Application #
9206595
Study Section
Special Emphasis Panel (ZAA1-DD (10)V)
Program Officer
Roach, Deidra
Project Start
2012-09-15
Project End
2021-08-31
Budget Start
2016-09-01
Budget End
2017-08-31
Support Year
5
Fiscal Year
2016
Total Cost
$311,314
Indirect Cost
$67,760
Name
Yale University
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
043207562
City
New Haven
State
CT
Country
United States
Zip Code
06520
Hawkins, Kellie L; Gordon, Kirsha S; Levin, Myron J et al. (2018) Herpes Zoster and Herpes Zoster Vaccine Rates Among Adults Living With and Without HIV in the Veterans Aging Cohort Study. J Acquir Immune Defic Syndr 79:527-533
Justice, Amy C; Gordon, Kirsha S; Skanderson, Melissa et al. (2018) Nonantiretroviral polypharmacy and adverse health outcomes among HIV-infected and uninfected individuals. AIDS 32:739-749
Li, Haifeng; Su, Linnan; Chen, Sheng et al. (2018) Physicochemical Characterization and Functional Analysis of the Polysaccharide from the Edible Microalga Nostoc sphaeroides. Molecules 23:
Khan, Maria R; McGinnis, Kathleen A; Grov, Christian et al. (2018) Past year and prior incarceration and HIV transmission risk among HIV-positive men who have sex with men in the US. AIDS Care :1-8
Justice, Amy C; Gordon, Kirsha; Skanderson, Melissa et al. (2018) Non antiretroviral polypharmacy and adverse health outcomes among HIV-infected and uninfected individuals. AIDS :
Rajeevan, Nallakkandi; Niehoff, Kristina M; Charpentier, Peter et al. (2017) Utilizing patient data from the veterans administration electronic health record to support web-based clinical decision support: informatics challenges and issues from three clinical domains. BMC Med Inform Decis Mak 17:111
Greene, Meredith; Justice, Amy C; Covinsky, Kenneth E (2017) Assessment of geriatric syndromes and physical function in people living with HIV. Virulence 8:586-598
Marshall, Brandon David Lewis; Tate, Janet P; Mcginnis, Kathleen A et al. (2017) Long-term alcohol use patterns and HIV disease severity: A joint trajectory analysis. AIDS :
Li, Haifeng; Han, Wenjing; Wang, Hongyu et al. (2017) Tanshinone IIA Inhibits Glutamate-Induced Oxidative Toxicity through Prevention of Mitochondrial Dysfunction and Suppression of MAPK Activation in SH-SY5Y Human Neuroblastoma Cells. Oxid Med Cell Longev 2017:4517486
Cain, Lauren E; Saag, Michael S; Petersen, Maya et al. (2016) Using observational data to emulate a randomized trial of dynamic treatment-switching strategies: an application to antiretroviral therapy. Int J Epidemiol 45:2038-2049

Showing the most recent 10 out of 57 publications