The State of Florida has the highest rate of new HIV diagnoses in the US. Its ongoing epidemic is characterized by significant racial disparities and special populations including women and men who have sex with men. The Southern HIV Alcohol Research Consortium (SHARC) was created as a CHAART in 2011 to address the impact of high-risk alcohol consumption on HIV outcomes in Florida. The consortium consists of three independently-funded research projects: a randomized clinical trial of naltrexone in HIV-infected women with high-risk drinking, an ongoing cohort study focusing on the impact of alcohol on neurocognition and aging in HIV, and an immunology study of the direct impact of alcohol (and naltrexone) on immune senescence over time. The projects build upon a successful research infrastructure that has already recruited over 800 persons with HIV in Miami, Florida, share clinical research resources, and have overlapping aims. However, the consortium lacks a central administrative infrastructure or mechanism to support new research as a whole. The SHARC Administrative and Research Support Core, submitted in response to RFA-AA-12-010, is critically needed to ensure coordination and communication across our consortium projects, to form new, multidisciplinary research collaborations, and to extend our research into additional public health settings within Florida.
The specific aims of this Core are (1) to create a self-sustaining, transdisciplinary research consortium addressing HIV and risky alcohol use in Florida (administrative core);(2) to expand our research and clinical trial capacities (research support);and (3) to expand multidisciplinary research and to mentor a new generation of scientists (education). Our investigators bring expertise in clinical trials methodology, clinical epidemiology, immunology, cognitive function, health services research, and exercise. Overall, the Core will support research that has significant impact by maximizing overall research productivity, increasing capacity to conduct clinical trials, enhancing collaborations, mentoring new researchers, and translating findings into clinical practice and public health settings that will improve health outcomes in persons with HIV and high-risk alcohol comorbidities.
This project has significant public health relevance, as the research is located in Florida (which has the highest rate of new HIV diagnoses in the US), the research addresses a significant health issue (HIV and high-risk alcohol comorbidities), and the research seeks to identify intervention strategies that can be readily adopted into routine clinica practice settings, including public health HIV clinics.
|Okafor, Chukwuemeka N; Kelso, Natalie E; Bryant, Vaughn et al. (2016) Body mass index, inflammatory biomarkers and neurocognitive impairment in HIV-infected persons. Psychol Health Med :1-14|
|Akhtar-Khaleel, Wajiha Z; Cook, Robert L; Shoptaw, Steve et al. (2016) Long-Term Cigarette Smoking Trajectories Among HIV-Seropositive and Seronegative MSM in the Multicenter AIDS Cohort Study. AIDS Behav 20:1713-21|
|Akhtar-Khaleel, Wajiha Z; Cook, Robert L; Shoptaw, Steven et al. (2016) Trends and Predictors of Cigarette Smoking Among HIV Seropositive and Seronegative Men: The Multicenter Aids Cohort Study. AIDS Behav 20:622-32|
|Seider, Talia R; Gongvatana, Assawin; Woods, Adam J et al. (2016) Age exacerbates HIV-associated white matter abnormalities. J Neurovirol 22:201-12|
|McGinnis, Kathleen A; Fiellin, David A; Tate, Janet P et al. (2016) Number of Drinks to "Feel a Buzz" by HIV Status and Viral Load in Men. AIDS Behav 20:504-11|
|Hu, Xingdi; Chen, Xinguang; Cook, Robert L et al. (2016) Modeling Drinking Behavior Progression in Youth with Cross-sectional Data: Solving an Under-identified Probabilistic Discrete Event System. Curr HIV Res 14:93-100|
|Cook, Robert L; Kelso, Natalie E; Brumback, Babette A et al. (2016) Analytic strategies to evaluate the association of time-varying exposures to HIV-related outcomes: Alcohol consumption as an example. Curr HIV Res 14:85-92|
|Hu, Xingdi; Harman, Jeffrey; Winterstein, Almut G et al. (2016) Utilization of Alcohol Treatment Among HIV-Positive Women with Hazardous Drinking. J Subst Abuse Treat 64:55-61|
|Okafor, Chukwuemeka N; Cook, Robert L; Chen, Xinguang et al. (2016) Trajectories of Marijuana Use among HIV-seropositive and HIV-seronegative MSM in the Multicenter AIDS Cohort Study (MACS), 1984-2013. AIDS Behav :|
|Li, Yuanfeng; Si, Lanlan; Zhai, Yun et al. (2016) Genome-wide association study identifies 8p21.3 associated with persistent hepatitis B virus infection among Chinese. Nat Commun 7:11664|
Showing the most recent 10 out of 30 publications