The Center for International Blood and Marrow Transplant Research (CIBMTR) is a clinical research program dedicated to addressing important issues in hematopoietic cell transplantation (HCT) by offering a unique resource of data and statistical expertise to the scientific community. The CIBMTR includes >400 HCT centers that share data on HCT outcomes and a Statistical Center that maintains a clinical database with information for more than 250,000 HCT recipients. These data and the analytic support available through the CIBMTR Statistical Center have led to successful completion of hundreds of studies. U24-CA76518 provides the primary support for these activities. This application requests funding for the next 5 years to support this resource in order to provide the biomedical community continued access to a high quality clinical database and statistical support to facilitate clinical research. Planned resource enhancements include development of electronic data acquisition technology to facilitate participation by a wide range of U.S. and non-U.S. HCT centers;collaboration with other domestic and international organizations to increase the data available to study transplantation for rare indications and new HCT technologies;collecting data on outcome of other therapeutic applications of hematopoietic stem cells;expanding data on late effects and long-term quality of life;and developing new biostatistical methodology to address the challenges, needs and opportunities in analyzing HCT outcomes. The CIBMTR is committed to meeting the needs of investigators in a rapidly evolving field. It has and will build on the infrastructure made possible by support from U24-CA76518 and partnership with others to better serve the research community. Activities during the current and previous funding cycles have led to not only many publications on important issues in HCT but also have created the opportunity for greatly expanded global collaboration in data exchange and observational HCT research and contributed substantially to the success of a U.S. multicenter clinical trials network in HCT. Enhancements already in progress and planned for the next funding cycle will allow more in-depth exploration of immunobiologic aspects of HCT and post-HCT QOL. In summary, the CIBMTR, with the support provided through U24-CA76518, continues to play a unique role in facilitating clinical research in HCT.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Resource-Related Research Projects--Cooperative Agreements (U24)
Project #
5U24CA076518-15
Application #
8245589
Study Section
Special Emphasis Panel (ZCA1-RTRB-L (J1))
Program Officer
Merritt, William D
Project Start
1998-03-01
Project End
2013-02-28
Budget Start
2012-03-01
Budget End
2013-02-28
Support Year
15
Fiscal Year
2012
Total Cost
$2,891,099
Indirect Cost
$490,454
Name
Medical College of Wisconsin
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
937639060
City
Milwaukee
State
WI
Country
United States
Zip Code
53226
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Vij, Ravi; Kumar, Shaji; Zhang, Mei-Jie et al. (2015) Impact of pretransplant therapy and depth of disease response before autologous transplantation for multiple myeloma. Biol Blood Marrow Transplant 21:335-41
Hong, S; Le-Rademacher, J; Artz, A et al. (2015) Comparison of non-myeloablative conditioning regimens for lymphoproliferative disorders. Bone Marrow Transplant 50:367-74
Kornblit, Brian; Enevold, Christian; Wang, Tao et al. (2015) Toll-like receptor polymorphisms in allogeneic hematopoietic cell transplantation. Biol Blood Marrow Transplant 21:259-65
Bachanova, V; Burns, L J; Wang, T et al. (2015) Alternative donors extend transplantation for patients with lymphoma who lack an HLA matched donor. Bone Marrow Transplant 50:197-203
Copelan, Edward A; Avalos, Belinda R; Ahn, Kwang Woo et al. (2015) Comparison of outcomes of allogeneic transplantation for chronic myeloid leukemia with cyclophosphamide in combination with intravenous busulfan, oral busulfan, or total body irradiation. Biol Blood Marrow Transplant 21:552-8
Kim, Sung-Yong; Le Rademacher, Jennifer; Antin, Joseph H et al. (2014) Myelodysplastic syndrome evolving from aplastic anemia treated with immunosuppressive therapy: efficacy of hematopoietic stem cell transplantation. Haematologica 99:1868-75
Broux, B; Shamim, Z; Wang, T et al. (2014) The influence of interleukin-7 receptor ?-chain haplotypes on outcome after allogeneic hematopoietic cell transplantation. Int J Immunogenet 41:521-7
Eckrich, Michael J; Ahn, Kwang-Woo; Champlin, Richard E et al. (2014) Effect of race on outcomes after allogeneic hematopoietic cell transplantation for severe aplastic anemia. Am J Hematol 89:125-9
Kelly, Michael J; Horan, John T; Alonzo, Todd A et al. (2014) Comparable survival for pediatric acute myeloid leukemia with poor-risk cytogenetics following chemotherapy, matched related donor, or unrelated donor transplantation. Pediatr Blood Cancer 61:269-75

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