The overall goal of this U24 application is to continue supporting a team of investigators to develop new and provide established, state-of-the-art high resolution mouse imaging techniques to local cancer investigators. The Harvard Small Animal Imaging Resource (SAIR) has a proven track record for innovation in molecular imaging and clinical translation, has served over 70 regional cancer investigators and currently performs imaging studies for over 40 cancer related base grants. The Program is affiliated with two NCI designated Cancer Centers (the Dana Farber Harvard Cancer Center (DFHCC) and the MIT Center for Cancer Research) and several Mouse Model of Human Cancer Consortia (MMHCC). The specific goals of the SAIR are to: 1) increase the availability and expand types of high resolution mouse imaging systems, 2) develop new techniques and methods to image cellular and molecular information of specific cancers and organs, 3) assist with image acquisition, 4) maintain and ensure the proper use of imaging equipment, 5) assist in image analysis, processing, quantitation, interpretation and image fusion and 6) provide training to investigators and collaborators with regard to a) small animal handling and monitoring, b) small animal imaging and c) the specifics of utilizing the array of imaging equipment best to address the specific questions at hand. Ancillary cores of this Program include a Pathology, Chemistry, Cell and Bioinformatics Cores. Multidisciplinary training will involve participation in hands-on projects, seminars and didactic lecture series. The overall focus of this proposal is to provide a shared resource and tools, which allow cancer researchers to incorporate state-of-the-art imaging technologies into their individual research studies. The SAIR has become a dynamic and diverse resource wherein exchange of techniques and ideas occurs rapidly and fosters interdisciplinary collaborations in cancer research.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Resource-Related Research Projects--Cooperative Agreements (U24)
Project #
5U24CA092782-09
Application #
7643326
Study Section
Special Emphasis Panel (ZCA1-GRB-S (J1))
Program Officer
Croft, Barbara
Project Start
2001-07-01
Project End
2012-06-30
Budget Start
2009-07-01
Budget End
2010-06-30
Support Year
9
Fiscal Year
2009
Total Cost
$493,355
Indirect Cost
Name
Massachusetts General Hospital
Department
Type
DUNS #
073130411
City
Boston
State
MA
Country
United States
Zip Code
02199
Gaglia, Jason L; Harisinghani, Mukesh; Aganj, Iman et al. (2015) Noninvasive mapping of pancreatic inflammation in recent-onset type-1 diabetes patients. Proc Natl Acad Sci U S A 112:2139-44
Robbins, Clinton S; Hilgendorf, Ingo; Weber, Georg F et al. (2013) Local proliferation dominates lesional macrophage accumulation in atherosclerosis. Nat Med 19:1166-72
Feruglio, Paolo Fumene; Vinegoni, Claudio; Fexon, Lioubov et al. (2013) Noise suppressed, multifocus image fusion for enhanced intraoperative navigation. J Biophotonics 6:363-70
Carlson, Jonathan C T; Meimetis, Labros G; Hilderbrand, Scott A et al. (2013) BODIPY-tetrazine derivatives as superbright bioorthogonal turn-on probes. Angew Chem Int Ed Engl 52:6917-20
Lu, Xin; Agasti, Sarit S; Vinegoni, Claudio et al. (2012) Optochemogenetics (OCG) allows more precise control of genetic engineering in mice with CreER regulators. Bioconjug Chem 23:1945-51
Hendricks, J Adam; Keliher, Edmund J; Wan, Dongpeng et al. (2012) Synthesis of [18F]BODIPY: bifunctional reporter for hybrid optical/positron emission tomography imaging. Angew Chem Int Ed Engl 51:4603-6
Zhang, Wei; Fulci, Giulia; Buhrman, Jason S et al. (2012) Bevacizumab with angiostatin-armed oHSV increases antiangiogenesis and decreases bevacizumab-induced invasion in U87 glioma. Mol Ther 20:37-45
Fu, Wenxian; Wojtkiewicz, Gregory; Weissleder, Ralph et al. (2012) Early window of diabetes determinism in NOD mice, dependent on the complement receptor CRIg, identified by noninvasive imaging. Nat Immunol 13:361-8
Chen, John W; Figueiredo, Jose-Luiz; Wojtkiewicz, Gregory R et al. (2012) Selective factor XIIa inhibition attenuates silent brain ischemia: application of molecular imaging targeting coagulation pathway. JACC Cardiovasc Imaging 5:1127-38
Ying, Haoqiang; Kimmelman, Alec C; Lyssiotis, Costas A et al. (2012) Oncogenic Kras maintains pancreatic tumors through regulation of anabolic glucose metabolism. Cell 149:656-70

Showing the most recent 10 out of 44 publications