Archived human tissues are an essential resource for translational research. Formalin-fixed, paraffin-embedded (FFPE) tissues from cancer patients are used in a w/ide range of assays, including RT-PCR, SNP profiling, multiplex biomarkers, imaging biomarkers, targeted exome, whole exome, and whole genome sequencing. Remainder FFPE tissues generated during patient care are 'retrospective';use of these tissues under specific conditions does not require consent. For personalized medicine researchers, these specimens are vital resources enabling biomarker validation, detailed molecular analysis, and systems modeling before application is made to individual patients. But access to these human tissues is often a rate limiting factor in cancer research. We propose advanced development of the TIES software to (1) increase institutional capacity for using FFPE to support molecular characterization of human tumors, (2) increase access to tissues within cancer centers, and (3) improve the ability to share tissues and associated phenotype data among cancer centers.

Public Health Relevance

(See Instructions): This work proposes the development of a software system that will enhance the ability of cancer researchers to find and use human tissues and accompanying electronic data for scientific research. By increasing access to tissues and data, this work seeks to increase the speed of scientific discoveries that will ultimately impact cancer patients.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Resource-Related Research Projects--Cooperative Agreements (U24)
Project #
1U24CA180921-01
Application #
8606937
Study Section
Special Emphasis Panel (ZCA1-SRLB-V (O1))
Program Officer
Ganguly, Aniruddha
Project Start
2013-09-25
Project End
2018-07-31
Budget Start
2013-09-25
Budget End
2014-07-31
Support Year
1
Fiscal Year
2013
Total Cost
$686,990
Indirect Cost
$153,032
Name
University of Pittsburgh
Department
Miscellaneous
Type
Schools of Medicine
DUNS #
004514360
City
Pittsburgh
State
PA
Country
United States
Zip Code
15213