The Animal Health and Welfare Core (AHWC) is responsible for receipt, certification, and husbandry of mice that are sent to Vanderbilt for the purpose of metabolic phenotyping. The AHWC is the interface between the Vanderbilt Division of Animal Care and the VMMPC. The responsibilites and services ofthis core are critical for the VMMPC to perform well-controlled experiments in non-stressed, healthy mice. The overall objective of the core is to facilitate the use of mice in diabetes, obesity and related research, ensure compliance and implement and maintain the health and colony numbers appropriate to the rate of center usage. Specifically the core is responsible for 1) receipt and documentation of incoming mice, 2) assignment and oversight of quarantine procedures, 3) provision of day-to-day husbandry, 4) provision of veterinary care and support, 5) performance of pathological assessments, and 6) implementation and maintenance of any specific dietary requirements.
The quality of data obtained from mouse phenotyping is determined in large part by the health ofthe mouse. This core is critical to ensure mice are healthy so that our experiments are accurate and reproducible.
|Williams, Ashley S; Trefts, Elijah; Lantier, Louise et al. (2017) Integrin-Linked Kinase Is Necessary for the Development of Diet-Induced Hepatic Insulin Resistance. Diabetes 66:325-334|
|Peterson, Kristin R; Flaherty, David K; Hasty, Alyssa H (2017) Obesity Alters B Cell and Macrophage Populations in Brown Adipose Tissue. Obesity (Silver Spring) 25:1881-1884|
|Woodard, Lauren E; Cheng, Jizhong; Welch, Richard C et al. (2017) Kidney-specific transposon-mediated gene transfer in vivo. Sci Rep 7:44904|
|Wanders, Desiree; Forney, Laura A; Stone, Kirsten P et al. (2017) FGF21 Mediates the Thermogenic and Insulin-Sensitizing Effects of Dietary Methionine Restriction but Not Its Effects on Hepatic Lipid Metabolism. Diabetes 66:858-867|
|Cadar, Adrian G; Feaster, Tromondae K; Durbin, Matthew D et al. (2017) Production of Single Contracting Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes: Matrigel Mattress Technique. Curr Protoc Stem Cell Biol 42:4A.14.1-4A.14.7|
|Felsted, Jennifer A; Chien, Cheng-Hao; Wang, Dongqing et al. (2017) Alpha2delta-1 in SF1+ Neurons of the Ventromedial Hypothalamus Is an Essential Regulator of Glucose and Lipid Homeostasis. Cell Rep 21:2737-2747|
|Hinder, Lucy M; O'Brien, Phillipe D; Hayes, John M et al. (2017) Dietary reversal of neuropathy in a murine model of prediabetes and metabolic syndrome. Dis Model Mech 10:717-725|
|Jao, Li-En; Akef, Abdalla; Wente, Susan R (2017) A role for Gle1, a regulator of DEAD-box RNA helicases, at centrosomes and basal bodies. Mol Biol Cell 28:120-127|
|Dickerson, Matthew T; Vierra, Nicholas C; Milian, Sarah C et al. (2017) Osteopontin activates the diabetes-associated potassium channel TALK-1 in pancreatic ?-cells. PLoS One 12:e0175069|
|Traver, Geri; Mont, Stacey; Gius, David et al. (2017) Loss of Nrf2 promotes alveolar type 2 cell loss in irradiated, fibrotic lung. Free Radic Biol Med 112:578-586|
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