The Administrative Core is directed by the PI, Dr Henri Brunengraber, who will oversee the whole management of the Case MMPC with the help of faculty and administrative staff. The Administrative Core will meet twice monthly with the Committee of Core Directors, and with the external Steering Committee (which will come to Cleveland once a year). The Administrative Core will interact with the other MMPCs, the NIDDK and NIHLB Program Directors in charge of the MMPCs, and with users. The Administrative Core will coordinate the operations of the cores and will manage all financial aspects of the MMPC administration. As an extension of the Administrative Core, the Training and Education Core (Drs Brunengraber, Croniger, Puchowicz) mentors users in the use of isotopic techniques, protocol design, analytical procedures, trouble shooting, and data interpretation. Also, the PI co-directs a one-week annual MMPC course on the use of isotopes for metabolic research.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Resource-Related Research Projects--Cooperative Agreements (U24)
Project #
5U24DK076174-02
Application #
8336861
Study Section
Special Emphasis Panel (ZDK1-GRB-S (M1))
Program Officer
Abraham, Kristin M
Project Start
2011-09-25
Project End
2016-05-31
Budget Start
2012-07-01
Budget End
2013-05-31
Support Year
2
Fiscal Year
2012
Total Cost
$531,724
Indirect Cost
$193,046
Name
Case Western Reserve University
Department
Nutrition
Type
Schools of Medicine
DUNS #
077758407
City
Cleveland
State
OH
Country
United States
Zip Code
44106
Mottillo, Emilio P; Balasubramanian, Priya; Lee, Yun-Hee et al. (2014) Coupling of lipolysis and de novo lipogenesis in brown, beige, and white adipose tissues during chronic ?3-adrenergic receptor activation. J Lipid Res 55:2276-86
Kelly, Karen R; Navaneethan, Sankar D; Solomon, Thomas P J et al. (2014) Lifestyle-induced decrease in fat mass improves adiponectin secretion in obese adults. Med Sci Sports Exerc 46:920-6
Du, Jinwei; Li, Qiang; Tang, Fangqiang et al. (2014) Cited2 is required for the maintenance of glycolytic metabolism in adult hematopoietic stem cells. Stem Cells Dev 23:83-94
Cannon, Matthew V; Buchner, David A; Hester, James et al. (2014) Maternal nutrition induces pervasive gene expression changes but no detectable DNA methylation differences in the liver of adult offspring. PLoS One 9:e90335
Tao, Hanlin; Zhang, Yong; Zeng, Xiangang et al. (2014) Niclosamide ethanolamine-induced mild mitochondrial uncoupling improves diabetic symptoms in mice. Nat Med 20:1263-9
Khan, Shenaz; Abu Jawdeh, Bassam G; Goel, Monu et al. (2014) Lipotoxic disruption of NHE1 interaction with PI(4,5)P2 expedites proximal tubule apoptosis. J Clin Invest 124:1057-68
Sadhukhan, Sushabhan; Han, Yong; Jin, Zhicheng et al. (2014) Glutathionylated 4-hydroxy-2-(E)-alkenal enantiomers in rat organs and their contributions toward the disposal of 4-hydroxy-2-(E)-nonenal in rat liver. Free Radic Biol Med 70:78-85
Ruiz, Rafaela; Jideonwo, Victoria; Ahn, Miwon et al. (2014) Sterol regulatory element-binding protein-1 (SREBP-1) is required to regulate glycogen synthesis and gluconeogenic gene expression in mouse liver. J Biol Chem 289:5510-7
Feng, Xiujing; Scott, Anthony; Wang, Yong et al. (2014) PTPRT regulates high-fat diet-induced obesity and insulin resistance. PLoS One 9:e100783
Prince, Allison; Zhang, Yifan; Croniger, Colleen et al. (2013) Oxidative metabolism: glucose versus ketones. Adv Exp Med Biol 789:323-8

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