Abstract

of Core A: Administrative Core The Administrative Core is directed by the PI, Dr Henri Brunengraber, who will oversee the whole management ofthe Case MMPC with the help of faculty and administrative staff. The Administrative Core will meet twice monthly with the Committee of Core Directors, and with the external Steering Committee (which will come to Cleveland once a year). The Administrative Core will interact with the other MMPCs, the NIDDK and NIHLB Program Directors in charge ofthe MMPCs, and with users. The Administrative Core will coordinate the operations ofthe cores and will manage all financial aspects ofthe MMPC administration. As an extension of the Administrative Core, the Training and Education Core (Drs Brunengraber, Croniger, Puchowicz) mentors users in the use of isotopic techniques, protocol design, analytical procedures, trouble shooting, and data interpretation. Also, the PI co-directs a one-week annual MMPC course on the use of isotopes for metabolic research.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Resource-Related Research Projects--Cooperative Agreements (U24)
Project #
5U24DK076174-04
Application #
8708042
Study Section
Special Emphasis Panel (ZDK1-GRB-S)
Project Start
Project End
Budget Start
2014-06-01
Budget End
2015-05-31
Support Year
4
Fiscal Year
2014
Total Cost
$75,893
Indirect Cost
$27,553

  Institution

Name
Case Western Reserve University
Department
Type
DUNS #
077758407
City
Cleveland
State
OH
Country
United States
Zip Code
44106

  Publications

Ko, Chih-Wei; Counihan, Daniel; Wu, Jing et al. (2018) Macrophages with a deletion of the phosphoenolpyruvate carboxykinase 1 (Pck1) gene have a more proinflammatory phenotype. J Biol Chem 293:3399-3409
Bederman, Ilya R; Pora, Gavriella; O'Reilly, Maureen et al. (2018) Absence of leptin signaling allows fat accretion in cystic fibrosis mice. Am J Physiol Gastrointest Liver Physiol 315:G685-G698
Roychowdhury, Sanjoy; McCullough, Rebecca L; Sanz-Garcia, Carlos et al. (2016) Receptor interacting protein 3 protects mice from high-fat diet-induced liver injury. Hepatology 64:1518-1533
Mosinski, J D; Pagadala, M R; Mulya, A et al. (2016) Gastric bypass surgery is protective from high-fat diet-induced non-alcoholic fatty liver disease and hepatic endoplasmic reticulum stress. Acta Physiol (Oxf) 217:141-51
Palczewski, Grzegorz; Widjaja-Adhi, M Airanthi K; Amengual, Jaume et al. (2016) Genetic dissection in a mouse model reveals interactions between carotenoids and lipid metabolism. J Lipid Res 57:1684-95
Li, Lei; Che, Li; Wang, Chunmei et al. (2016) [(11)C]acetate PET Imaging is not Always Associated with Increased Lipogenesis in Hepatocellular Carcinoma in Mice. Mol Imaging Biol 18:360-7
Mera, Paula; Laue, Kathrin; Ferron, Mathieu et al. (2016) Osteocalcin Signaling in Myofibers Is Necessary and Sufficient for Optimum Adaptation to Exercise. Cell Metab 23:1078-1092
Zhang, Yifan; Zhang, Shenghui; Marin-Valencia, Isaac et al. (2015) Decreased carbon shunting from glucose toward oxidative metabolism in diet-induced ketotic rat brain. J Neurochem 132:301-12
DeSantis, David A; Ko, Chih-Wei; Wang, Lan et al. (2015) Constitutive Activation of the Nlrc4 Inflammasome Prevents Hepatic Fibrosis and Promotes Hepatic Regeneration after Partial Hepatectomy. Mediators Inflamm 2015:909827
Cordoba-Chacon, Jose; Majumdar, Neena; List, Edward O et al. (2015) Growth Hormone Inhibits Hepatic De Novo Lipogenesis in Adult Mice. Diabetes 64:3093-103

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