A well-organized Administrative Core is essential to ensure the efficiency and success ofthe MMPC. To that end, the Administrative Core will be the first entry point to the MMPC-UCD for reseachers wanting to phenotype their mouse lines for diabetes, obesity, and diabetic complications. To do so, the Administrative Core will maintain MMPC budgetary and workflow records, oversee the importation and workflow assignments for strains submitted for services, establish, standardize, document, and distribute phenotyping protocols, provide quality assurance (QA) and quality control (QC) procedures, provide and take responsibility for budgetary oversight, consult and interact with, and provide input to, the Coordinating and Bioinformatics Unit (CBU), establish a Center Steering Committee to provide scientific and administrative oversight, participate in all external committee meetings and assignments, establish and coordinate a Research and Development (R&D) program, and participate in an Opportunity Pool Programs to fund Pilot and Feasibility studies and other projects.

Public Health Relevance

Mouse models of diabetes, diabetic complications, obesity and other related disorders have been invaluable for elucidating the disease potential, pathogenesis and treatment of these conditions in the human population. The Administrative Core will provide leadership and direction for all projects to phenotype the mouse lines in order to identify and characterize potential mouse models for study of human disease

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Resource-Related Research Projects--Cooperative Agreements (U24)
Project #
1U24DK092993-01
Application #
8204174
Study Section
Special Emphasis Panel (ZDK1-GRB-S (M1))
Project Start
Project End
Budget Start
2011-09-16
Budget End
2012-06-30
Support Year
1
Fiscal Year
2011
Total Cost
$157,291
Indirect Cost
Name
University of California Davis
Department
Type
DUNS #
047120084
City
Davis
State
CA
Country
United States
Zip Code
95618
Majtan, Tomas; Jones Jr, Wendell; Krijt, Jakub et al. (2018) Enzyme Replacement Therapy Ameliorates Multiple Symptoms of Murine Homocystinuria. Mol Ther 26:834-844
Yokoyama, Amy S; Dunaway, Keith; Rutkowsky, Jennifer et al. (2018) Chronic consumption of a western diet modifies the DNA methylation profile in the frontal cortex of mice. Food Funct 9:1187-1198
Rutkowsky, Jennifer M; Lee, Linda L; Puchowicz, Michelle et al. (2018) Reduced cognitive function, increased blood-brain-barrier transport and inflammatory responses, and altered brain metabolites in LDLr -/-and C57BL/6 mice fed a western diet. PLoS One 13:e0191909
Cheng, Yingduan; Yuan, Quan; Vergnes, Laurent et al. (2018) KDM4B protects against obesity and metabolic dysfunction. Proc Natl Acad Sci U S A 115:E5566-E5575
Rozman, Jan; Rathkolb, Birgit; Oestereicher, Manuela A et al. (2018) Identification of genetic elements in metabolism by high-throughput mouse phenotyping. Nat Commun 9:288
Inceoglu, Bora; Bettaieb, Ahmed; Haj, Fawaz G et al. (2017) Modulation of mitochondrial dysfunction and endoplasmic reticulum stress are key mechanisms for the wide-ranging actions of epoxy fatty acids and soluble epoxide hydrolase inhibitors. Prostaglandins Other Lipid Mediat 133:68-78
Havel, Peter J; Kievit, Paul; Comuzzie, Anthony G et al. (2017) Use and Importance of Nonhuman Primates in Metabolic Disease Research: Current State of the Field. ILAR J 58:251-268
Baldassini, W A; Ramsey, J J; Hagopian, K et al. (2017) The influence of Shc proteins and high-fat diet on energy metabolism of mice. Cell Biochem Funct 35:527-537
Hsu, Ming-Fo; Bettaieb, Ahmed; Ito, Yoshihiro et al. (2017) Protein tyrosine phosphatase Shp2 deficiency in podocytes attenuates lipopolysaccharide-induced proteinuria. Sci Rep 7:461
McGavigan, Anne K; Garibay, Darline; Henseler, Zachariah M et al. (2017) TGR5 contributes to glucoregulatory improvements after vertical sleeve gastrectomy in mice. Gut 66:226-234

Showing the most recent 10 out of 74 publications