A well-organized Administrative Core is essential to ensure the efficiency and success ofthe MMPC. To that end, the Administrative Core will be the first entry point to the MMPC-UCD for reseachers wanting to phenotype their mouse lines for diabetes, obesity, and diabetic complications. To do so, the Administrative Core will maintain MMPC budgetary and workflow records, oversee the importation and workflow assignments for strains submitted for services, establish, standardize, document, and distribute phenotyping protocols, provide quality assurance (QA) and quality control (QC) procedures, provide and take responsibility for budgetary oversight, consult and interact with, and provide input to, the Coordinating and Bioinformatics Unit (CBU), establish a Center Steering Committee to provide scientific and administrative oversight, participate in all external committee meetings and assignments, establish and coordinate a Research and Development (R&D) program, and participate in an Opportunity Pool Programs to fund Pilot and Feasibility studies and other projects.

Public Health Relevance

Mouse models of diabetes, diabetic complications, obesity and other related disorders have been invaluable for elucidating the disease potential, pathogenesis and treatment of these conditions in the human population. The Administrative Core will provide leadership and direction for all projects to phenotype the mouse lines in order to identify and characterize potential mouse models for study of human disease

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Resource-Related Research Projects--Cooperative Agreements (U24)
Project #
5U24DK092993-02
Application #
8381206
Study Section
Special Emphasis Panel (ZDK1-GRB-S)
Project Start
Project End
Budget Start
2012-07-01
Budget End
2013-05-31
Support Year
2
Fiscal Year
2012
Total Cost
$248,819
Indirect Cost
$65,864
Name
University of California Davis
Department
Type
DUNS #
047120084
City
Davis
State
CA
Country
United States
Zip Code
95618
Huang, Wei-Hsiang; Guenthner, Casey J; Xu, Jin et al. (2016) Molecular and Neural Functions of Rai1, the Causal Gene for Smith-Magenis Syndrome. Neuron 92:392-406
Dickel, Diane E; Barozzi, Iros; Zhu, Yiwen et al. (2016) Genome-wide compendium and functional assessment of in vivo heart enhancers. Nat Commun 7:12923
Ng, Kit Fai; Anderson, Steve; Mayo, Patrice et al. (2016) Characterizing blood-brain barrier perturbations after exposure to human triglyceride-rich lipoprotein lipolysis products using MRI in a rat model. Magn Reson Med 76:1246-51
Lloyd, K C Kent; Khanna, Chand; Hendricks, William et al. (2016) Precision medicine: an opportunity for a paradigm shift in veterinary medicine. J Am Vet Med Assoc 248:45-8
Aung, Hnin Hnin; Altman, Robin; Nyunt, Tun et al. (2016) Lipotoxic brain microvascular injury is mediated by activating transcription factor 3-dependent inflammatory and oxidative stress pathways. J Lipid Res 57:955-68
Green, Adrian J; Graham, James L; Gonzalez, Eduardo A et al. (2016) Perinatal triphenyl phosphate exposure accelerates type 2 diabetes onset and increases adipose accumulation in UCD-type 2 diabetes mellitus rats. Reprod Toxicol :
Lloyd, Kent; Franklin, Craig; Lutz, Cat et al. (2015) Reproducibility: use mouse biobanks or lose them. Nature 522:151-3
Flynn, Charles Robb; Albaugh, Vance L; Cai, Steven et al. (2015) Bile diversion to the distal small intestine has comparable metabolic benefits to bariatric surgery. Nat Commun 6:7715
Walton, Jeffrey H; Ng, Kit Fai; Anderson, Steven E et al. (2015) MRI measurement of blood-brain barrier transport with a rapid acquisition refocused echo (RARE) method. Biochem Biophys Res Commun 463:479-82
Bettaieb, Ahmed; Hosein, Ellen; Chahed, Samah et al. (2015) Decreased adiposity and enhanced glucose tolerance in shikonin treated mice. Obesity (Silver Spring) 23:2269-77

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