The primary mission ofthe MMPC-UCD Body Composition, Thermoregulation, and Food Intake Behavior Core is to provide our clients with in-depth assessements of molecular and whole-animal phenomena relevant to body weight regulation and metabolism. In addition to providing essential basic metabolic phenotyping services and expertise, the Core has a unique strength in the application of challenge tests designed to unmask subtle phenotypes associated with energy balance and gut function. In addition, the Core will conduct pilot and feasibility studies with a goal to institute new mouse phenotyping approaches that will be useful to the MMPC-UCD and the MMPC system as a whole. Investigators participating in this Core have proven capabilities in studying mouse thermogenesis, adipose tissue biology, and energy balance regulators including gut signals. The MMPC-UCD Body Composition, Thermoregulation, and Food Intake Behavior Core will employ assays that complement and extend those offered by existing MMPCs, using state-of-the-art approaches and a unique perspective that includes an appreciation ofthe roles of gut physiology and peripheral neuron function.

Public Health Relevance

Mouse models of diabetes, diabetic complications, obesity and other related disorders have been invaluable for elucidating the disease potential, pathogenesis and treatment of these conditions in the human population. The Body Composition, Thermoregulation, and Food Intabke Behavior Core will conduct procedures and analyses on mouse lines submitted to the MMPC-UCD in order to identify potentail mouse models of human disease for study.

National Institute of Health (NIH)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Resource-Related Research Projects--Cooperative Agreements (U24)
Project #
Application #
Study Section
Special Emphasis Panel (ZDK1-GRB-S)
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of California Davis
United States
Zip Code
Chen, Zhongyi; Guo, Lilu; Zhang, Yongqin et al. (2014) Incorporation of therapeutically modified bacteria into gut microbiota inhibits obesity. J Clin Invest 124:3391-406
La Merrill, Michele; Karey, Emma; Moshier, Erin et al. (2014) Perinatal exposure of mice to the pesticide DDT impairs energy expenditure and metabolism in adult female offspring. PLoS One 9:e103337
Buss, Julia; Havel, Peter J; Epel, Elissa et al. (2014) Associations of ghrelin with eating behaviors, stress, metabolic factors, and telomere length among overweight and obese women: preliminary evidence of attenuated ghrelin effects in obesity? Appetite 76:84-94
de Lartigue, Guillaume; Ronveaux, Charlotte C; Raybould, Helen E (2014) Deletion of leptin signaling in vagal afferent neurons results in hyperphagia and obesity. Mol Metab 3:595-607
Yahiatène, Idir; Aung, Hnin H; Wilson, Dennis W et al. (2014) Single-molecule quantification of lipotoxic expression of activating transcription factor 3. Phys Chem Chem Phys 16:21595-601
Zhou, Peng; Hummel, Alyssa D; Pywell, Cameron M et al. (2014) High fat diet rescues disturbances to metabolic homeostasis and survival in the Id2 null mouse in a sex-specific manner. Biochem Biophys Res Commun 451:374-81
Tao, Hanlin; Zhang, Yong; Zeng, Xiangang et al. (2014) Niclosamide ethanolamine-induced mild mitochondrial uncoupling improves diabetic symptoms in mice. Nat Med 20:1263-9