A well-organized Administrative Core is essential to ensure the efficiency and success ofthe MMPC. To that end, the Administrative Core will be the first entry point to the MMPC-UCD for reseachers wanting to phenotype their mouse lines for diabetes, obesity, and diabetic complications. To do so, the Administrative Core will maintain MMPC budgetary and workflow records, oversee the importation and workflow assignments for strains submitted for services, establish, standardize, document, and distribute phenotyping protocols, provide quality assurance (QA) and quality control (QC) procedures, provide and take responsibility for budgetary oversight, consult and interact with, and provide input to, the Coordinating and Bioinformatics Unit (CBU), establish a Center Steering Committee to provide scientific and administrative oversight, participate in all external committee meetings and assignments, establish and coordinate a Research and Development (R&D) program, and participate in an Opportunity Pool Programs to fund Pilot and Feasibility studies and other projects.

Public Health Relevance

Mouse models of diabetes, diabetic complications, obesity and other related disorders have been invaluable for elucidating the disease potential, pathogenesis and treatment of these conditions in the human population. The Administrative Core will provide leadership and direction for all projects to phenotype the mouse lines in order to identify and characterize potential mouse models for study of human disease.

National Institute of Health (NIH)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Resource-Related Research Projects--Cooperative Agreements (U24)
Project #
Application #
Study Section
Special Emphasis Panel (ZDK1-GRB-S)
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of California Davis
United States
Zip Code
Chen, Zhongyi; Guo, Lilu; Zhang, Yongqin et al. (2014) Incorporation of therapeutically modified bacteria into gut microbiota inhibits obesity. J Clin Invest 124:3391-406
La Merrill, Michele; Karey, Emma; Moshier, Erin et al. (2014) Perinatal exposure of mice to the pesticide DDT impairs energy expenditure and metabolism in adult female offspring. PLoS One 9:e103337
Buss, Julia; Havel, Peter J; Epel, Elissa et al. (2014) Associations of ghrelin with eating behaviors, stress, metabolic factors, and telomere length among overweight and obese women: preliminary evidence of attenuated ghrelin effects in obesity? Appetite 76:84-94
de Lartigue, Guillaume; Ronveaux, Charlotte C; Raybould, Helen E (2014) Deletion of leptin signaling in vagal afferent neurons results in hyperphagia and obesity. Mol Metab 3:595-607
Yahiatène, Idir; Aung, Hnin H; Wilson, Dennis W et al. (2014) Single-molecule quantification of lipotoxic expression of activating transcription factor 3. Phys Chem Chem Phys 16:21595-601
Zhou, Peng; Hummel, Alyssa D; Pywell, Cameron M et al. (2014) High fat diet rescues disturbances to metabolic homeostasis and survival in the Id2 null mouse in a sex-specific manner. Biochem Biophys Res Commun 451:374-81
Tao, Hanlin; Zhang, Yong; Zeng, Xiangang et al. (2014) Niclosamide ethanolamine-induced mild mitochondrial uncoupling improves diabetic symptoms in mice. Nat Med 20:1263-9