The heart of this application is a smoothly functioning, high-through-put Animal Core that can provide animal care that meets or exceeds The Guide standards while meeting the needs of the phenotyping core investigator and the phenotyping core laboratories. The Animal Core for the Mouse Metabolic Phenotyping Center (MMPC) at UCD (MMPC-UCD) will be comprised of space, resource, and personnel within the UCD Mouse Biology Program (MBP). MBP focuses on expanding knowledge ofthe biology of laboratory mice and on the application of genetically-altered mice in biomedical research. Among the many projects relying on MBP support and vivarium services are the NIH/NCRR's Mutant Mouse Regional Resources Centers (MMRRC) and the trans-NIH Knock Out Mouse Project (KOMP) Repository. MBP is already engaged in working with investigators around the globe coordinating rodent imports and exports;creating, expanding and cryoarchiving lines of genetically altered mice;assisting research planning using genetically altered mice (age, gender, number, genetic background, special husbandry requirements, etc);and providing stewardship and oversight of animal care and health for all mice housed in MBP. With the MBP operational and management program within the University and our close working relationship with the UCD Institutional Animal Care and Use Committee (lACUC), the Attending Veterinarian, and rodent infectious disease specialists, MBP has wide latitude in the importation, quarantine and housing of mice of varying health statuses. With this experience and these operational programs in place, we are uniquely qualified to provide rodent importation, acclimation/quarantine, housing, health monitoring and project scheduling that will be conducive for rapid and efficient evaluation of strains submitted to MMPC-UCD for phenotyping. This Animal Core will have the institutional resources and authority to import and acclimate/quarantine mice for further phenotypic analysis with minimal delay. This will broaden the availability of metabolic phenotyping tests by allowing more investigator mice to be imported and analyzed, and expedite generation of data and completion of research using these mice in a more timely fashion.
Mouse models of diabetes, diabetic complications, obesity and other related disorders have been invaluable for elucidating the disease potential, pathogenesis and treatment of these conditions in the human population. This animal core will provide stewardship and oversight for these animals that meets and exceeds federal and institutional policies and guidelines on the care and use of animals used in biomedical research.
|Majtan, Tomas; Jones Jr, Wendell; Krijt, Jakub et al. (2018) Enzyme Replacement Therapy Ameliorates Multiple Symptoms of Murine Homocystinuria. Mol Ther 26:834-844|
|Yokoyama, Amy S; Dunaway, Keith; Rutkowsky, Jennifer et al. (2018) Chronic consumption of a western diet modifies the DNA methylation profile in the frontal cortex of mice. Food Funct 9:1187-1198|
|Rutkowsky, Jennifer M; Lee, Linda L; Puchowicz, Michelle et al. (2018) Reduced cognitive function, increased blood-brain-barrier transport and inflammatory responses, and altered brain metabolites in LDLr -/-and C57BL/6 mice fed a western diet. PLoS One 13:e0191909|
|Cheng, Yingduan; Yuan, Quan; Vergnes, Laurent et al. (2018) KDM4B protects against obesity and metabolic dysfunction. Proc Natl Acad Sci U S A 115:E5566-E5575|
|Rozman, Jan; Rathkolb, Birgit; Oestereicher, Manuela A et al. (2018) Identification of genetic elements in metabolism by high-throughput mouse phenotyping. Nat Commun 9:288|
|López-Yoldi, Miguel; Stanhope, Kimber L; Garaulet, Marta et al. (2017) Role of cardiotrophin-1 in the regulation of metabolic circadian rhythms and adipose core clock genes in mice and characterization of 24-h circulating CT-1 profiles in normal-weight and overweight/obese subjects. FASEB J 31:1639-1649|
|Jung, Chris J; Zhang, Junli; Trenchard, Elizabeth et al. (2017) Efficient gene targeting in mouse zygotes mediated by CRISPR/Cas9-protein. Transgenic Res 26:263-277|
|Green, Adrian J; Graham, James L; Gonzalez, Eduardo A et al. (2017) Perinatal triphenyl phosphate exposure accelerates type 2 diabetes onset and increases adipose accumulation in UCD-type 2 diabetes mellitus rats. Reprod Toxicol 68:119-129|
|Ono-Moore, Kikumi D; Zhao, Ling; Huang, Shurong et al. (2017) Transgenic mice with ectopic expression of constitutively active TLR4 in adipose tissues do not show impaired insulin sensitivity. Immun Inflamm Dis 5:526-540|
|Vogel Ciernia, Annie; Pride, Michael C; Durbin-Johnson, Blythe et al. (2017) Early motor phenotype detection in a female mouse model of Rett syndrome is improved by cross-fostering. Hum Mol Genet 26:1839-1854|
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