The main objective of the Metabolism and Endocrinology Core is to provide the expertise, technical resources, and instrumentation necessary to characterize perturbations in metabolism in murine models potentially useful for understanding diabetes, its complications, obesity, and related metabolic disorders. The core will conduct in vivo and in vitro metabolic procedures and offer an extensive list of assays of metabolic substrates, endocrine hormones, and indices of renal function, inflammation and oxidative stress. In addition, the Metabolism and Endocrinology Core will provide assay management services for the analysis of samples generated by all cores.
Mouse models of diabetes, diabetic complications, obesity and other related disorders have been invaluable for elucidating the disease potential, pathogenesis and treatment of these conditions in the human population. The Metabolism and Endocrinology Core will conduct procedures and analyses on mouse lines submitted to the MMPC-UCD in order to identify potential mouse models of human disease for study.
|Majtan, Tomas; Jones Jr, Wendell; Krijt, Jakub et al. (2018) Enzyme Replacement Therapy Ameliorates Multiple Symptoms of Murine Homocystinuria. Mol Ther 26:834-844|
|Yokoyama, Amy S; Dunaway, Keith; Rutkowsky, Jennifer et al. (2018) Chronic consumption of a western diet modifies the DNA methylation profile in the frontal cortex of mice. Food Funct 9:1187-1198|
|Rutkowsky, Jennifer M; Lee, Linda L; Puchowicz, Michelle et al. (2018) Reduced cognitive function, increased blood-brain-barrier transport and inflammatory responses, and altered brain metabolites in LDLr -/-and C57BL/6 mice fed a western diet. PLoS One 13:e0191909|
|Cheng, Yingduan; Yuan, Quan; Vergnes, Laurent et al. (2018) KDM4B protects against obesity and metabolic dysfunction. Proc Natl Acad Sci U S A 115:E5566-E5575|
|Rozman, Jan; Rathkolb, Birgit; Oestereicher, Manuela A et al. (2018) Identification of genetic elements in metabolism by high-throughput mouse phenotyping. Nat Commun 9:288|
|López-Yoldi, Miguel; Stanhope, Kimber L; Garaulet, Marta et al. (2017) Role of cardiotrophin-1 in the regulation of metabolic circadian rhythms and adipose core clock genes in mice and characterization of 24-h circulating CT-1 profiles in normal-weight and overweight/obese subjects. FASEB J 31:1639-1649|
|Jung, Chris J; Zhang, Junli; Trenchard, Elizabeth et al. (2017) Efficient gene targeting in mouse zygotes mediated by CRISPR/Cas9-protein. Transgenic Res 26:263-277|
|Green, Adrian J; Graham, James L; Gonzalez, Eduardo A et al. (2017) Perinatal triphenyl phosphate exposure accelerates type 2 diabetes onset and increases adipose accumulation in UCD-type 2 diabetes mellitus rats. Reprod Toxicol 68:119-129|
|Ono-Moore, Kikumi D; Zhao, Ling; Huang, Shurong et al. (2017) Transgenic mice with ectopic expression of constitutively active TLR4 in adipose tissues do not show impaired insulin sensitivity. Immun Inflamm Dis 5:526-540|
|Vogel Ciernia, Annie; Pride, Michael C; Durbin-Johnson, Blythe et al. (2017) Early motor phenotype detection in a female mouse model of Rett syndrome is improved by cross-fostering. Hum Mol Genet 26:1839-1854|
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