The main objective of the Metabolism and Endocrinology Core is to provide the expertise, technical resources, and instrumentation necessary to characterize perturbations in metabolism in murine models potentially useful for understanding diabetes, its complications, obesity, and related metabolic disorders. The core will conduct in vivo and in vitro metabolic procedures and offer an extensive list of assays of metabolic substrates, endocrine hormones, and indices of renal function, inflammation and oxidative stress. In addition, the Metabolism and Endocrinology Core will provide assay management services for the analysis of samples generated by all cores.

Public Health Relevance

Mouse models of diabetes, diabetic complications, obesity and other related disorders have been invaluable for elucidating the disease potential, pathogenesis and treatment of these conditions in the human population. The Metabolism and Endocrinology Core will conduct procedures and analyses on mouse lines submitted to the MMPC-UCD in order to identify potential mouse models of human disease for study.

National Institute of Health (NIH)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Resource-Related Research Projects--Cooperative Agreements (U24)
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Special Emphasis Panel (ZDK1-GRB-S)
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University of California Davis
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Chen, Zhongyi; Guo, Lilu; Zhang, Yongqin et al. (2014) Incorporation of therapeutically modified bacteria into gut microbiota inhibits obesity. J Clin Invest 124:3391-406
La Merrill, Michele; Karey, Emma; Moshier, Erin et al. (2014) Perinatal exposure of mice to the pesticide DDT impairs energy expenditure and metabolism in adult female offspring. PLoS One 9:e103337
Buss, Julia; Havel, Peter J; Epel, Elissa et al. (2014) Associations of ghrelin with eating behaviors, stress, metabolic factors, and telomere length among overweight and obese women: preliminary evidence of attenuated ghrelin effects in obesity? Appetite 76:84-94
de Lartigue, Guillaume; Ronveaux, Charlotte C; Raybould, Helen E (2014) Deletion of leptin signaling in vagal afferent neurons results in hyperphagia and obesity. Mol Metab 3:595-607
Yahiatène, Idir; Aung, Hnin H; Wilson, Dennis W et al. (2014) Single-molecule quantification of lipotoxic expression of activating transcription factor 3. Phys Chem Chem Phys 16:21595-601
Zhou, Peng; Hummel, Alyssa D; Pywell, Cameron M et al. (2014) High fat diet rescues disturbances to metabolic homeostasis and survival in the Id2 null mouse in a sex-specific manner. Biochem Biophys Res Commun 451:374-81
Tao, Hanlin; Zhang, Yong; Zeng, Xiangang et al. (2014) Niclosamide ethanolamine-induced mild mitochondrial uncoupling improves diabetic symptoms in mice. Nat Med 20:1263-9