Abstract

A well-organized Administrative Core is essential to ensure the efficiency and success of the MMPC. To that end, the Administrative Core will be the first entry point to the MMPC-UCD for researchers wanting to phenotype their mouse lines for diabetes, obesity, and diabetic complications. To do so, the Administrative Core will maintain MMPC budgetary and workflow records, oversee the importation and workflow assignments for strains submitted for services, establish, standardize, document, and distribute phenotyping protocols, provide quality assurance (QA) and quality control (QC) procedures, provide and take responsibility for budgetary oversight, consult and interact with, and provide input to, the Coordinating and Bioinformatics Unit (CBU), establish a Center Steering Committee to provide scientific and administrative oversight, participate in all external committee meetings and assignments, establish and coordinate a Research and Development (R&D) program, and participate in an Opportunity Pool Programs to fund Pilot and Feasibility studies and other projects.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Resource-Related Research Projects--Cooperative Agreements (U24)
Project #
5U24DK092993-05
Application #
8878235
Study Section
Special Emphasis Panel (ZDK1)
Program Officer
Abraham, Kristin M
Project Start
2011-09-16
Project End
2016-08-01
Budget Start
2015-06-01
Budget End
2016-08-01
Support Year
5
Fiscal Year
2015
Total Cost
Indirect Cost

  Institution

Name
University of California Davis
Department
Surgery
Type
Schools of Medicine
DUNS #
047120084
City
Davis
State
CA
Country
United States
Zip Code
95618

  Publications

Rozman, Jan; Rathkolb, Birgit; Oestereicher, Manuela A et al. (2018) Identification of genetic elements in metabolism by high-throughput mouse phenotyping. Nat Commun 9:288
Majtan, Tomas; Jones Jr, Wendell; Krijt, Jakub et al. (2018) Enzyme Replacement Therapy Ameliorates Multiple Symptoms of Murine Homocystinuria. Mol Ther 26:834-844
Yokoyama, Amy S; Dunaway, Keith; Rutkowsky, Jennifer et al. (2018) Chronic consumption of a western diet modifies the DNA methylation profile in the frontal cortex of mice. Food Funct 9:1187-1198
Rutkowsky, Jennifer M; Lee, Linda L; Puchowicz, Michelle et al. (2018) Reduced cognitive function, increased blood-brain-barrier transport and inflammatory responses, and altered brain metabolites in LDLr -/-and C57BL/6 mice fed a western diet. PLoS One 13:e0191909
Cheng, Yingduan; Yuan, Quan; Vergnes, Laurent et al. (2018) KDM4B protects against obesity and metabolic dysfunction. Proc Natl Acad Sci U S A 115:E5566-E5575
Hsu, Ming-Fo; Bettaieb, Ahmed; Ito, Yoshihiro et al. (2017) Protein tyrosine phosphatase Shp2 deficiency in podocytes attenuates lipopolysaccharide-induced proteinuria. Sci Rep 7:461
McGavigan, Anne K; Garibay, Darline; Henseler, Zachariah M et al. (2017) TGR5 contributes to glucoregulatory improvements after vertical sleeve gastrectomy in mice. Gut 66:226-234
Ito, Yoshihiro; Hsu, Ming-Fo; Bettaieb, Ahmed et al. (2017) Protein tyrosine phosphatase 1B deficiency in podocytes mitigates hyperglycemia-induced renal injury. Metabolism 76:56-69
López-Yoldi, Miguel; Stanhope, Kimber L; Garaulet, Marta et al. (2017) Role of cardiotrophin-1 in the regulation of metabolic circadian rhythms and adipose core clock genes in mice and characterization of 24-h circulating CT-1 profiles in normal-weight and overweight/obese subjects. FASEB J 31:1639-1649
Jung, Chris J; Zhang, Junli; Trenchard, Elizabeth et al. (2017) Efficient gene targeting in mouse zygotes mediated by CRISPR/Cas9-protein. Transgenic Res 26:263-277

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