The Promotion and Outreach Core (P/O Core) of the Michigan Regional Comprehensive Metabolomic Resource Core (MRC2) will promote adoption of metabolomics technology to augment biomedical research and increase utilization of national Regional Comprehensive Metabolomics Resource Cores (RCMRCs). The P/O Core will leverage the support of 3 outstanding programs at the University of Michigan and their associated infrastructure: the School of Education, the Outreach and Dissemination Core of the National Center for Integrative Biomedical Informatics and the Education Core of the Michigan Institute for Clinical and Human Research (MICHR) home to the university's Clinical Translational Sciences Award (CTSA). The P/O Core will continue successful programs currently offered by the Michigan Metabolomics and Obesity Center. In addition, the Core will develop a Metabolomics Seminar Series, featuring external and UM speakers, develop a yearly Metabolomics Immersion Workshop and support an Individualized Multi-Week Metabolomics Instruction Program (Visiting Scientist Program). To disseminate material to a wider audience, the P/O, through the MRC2 website will offer on-line metabolomics instruction, including video and podcasts of the symposium, seminar series and select segments of the immersion workshop, develop short YouTube? videos which will provide information on metabolomics methodology with demonstration of the use of the University of Michigan metabolomics LIMS system, statistical packages and bioinformatics tools. The Core will develop user-centered interface Metabolomics Online to facilitate finding statistical and bioinformatic tools for metabolomic inside UM and external sites, including the RCMRCs. The site will also support a Wiki for interaction among the RCMRC to facilitate interaction and exchange of ideas. The P/6 core will support training of Post-graduates in metabolomics technology and informatics. Finally, the Core will support a traditional Pilot and Feasibility Program and a novel 'Small Pilot and Feasibility Program'that is modeled on a successful UM program to provide,rapid assistance for researchers to access the MRC2 infrastructure.
The development of metabolomics has increased interest in the use of the technology by a broad range of scientists. The increased use of the technology will lead to increased understanding of disease. By supporting a variety of educational and outreach programs, the Promotion and Outreach Core will allow a larger number of scientists to understand metabolomics to use the technology in their research programs.
|Noori, S; McNamara, P; Jain, A et al. (2015) Catecholamine-resistant hypotension and myocardial performance following patent ductus arteriosus ligation. J Perinatol 35:123-7|
|Puskarich, Michael A; Finkel, Michael A; Karnovsky, Alla et al. (2015) Pharmacometabolomics of l-carnitine treatment response phenotypes in patients with septic shock. Ann Am Thorac Soc 12:46-56|
|Lanning, Nathan J; Looyenga, Brendan D; Kauffman, Audra L et al. (2014) A mitochondrial RNAi screen defines cellular bioenergetic determinants and identifies an adenylate kinase as a key regulator of ATP levels. Cell Rep 7:907-17|
|Clyman, Ronald I; Wickremasinghe, Andrea; Merritt, T Allen et al. (2014) Hypotension following patent ductus arteriosus ligation: the role of adrenal hormones. J Pediatr 164:1449-55.e1|
|Bassis, Christine M; Theriot, Casey M; Young, Vincent B (2014) Alteration of the murine gastrointestinal microbiota by tigecycline leads to increased susceptibility to Clostridium difficile infection. Antimicrob Agents Chemother 58:2767-74|
|Theriot, Casey M; Koenigsknecht, Mark J; Carlson Jr, Paul E et al. (2014) Antibiotic-induced shifts in the mouse gut microbiome and metabolome increase susceptibility to Clostridium difficile infection. Nat Commun 5:3114|
|Parlee, Sebastian D; Simon, Becky R; Scheller, Erica L et al. (2014) Administration of saccharin to neonatal mice influences body composition of adult males and reduces body weight of females. Endocrinology 155:1313-26|
|Michaud, Dominique S; Izard, Jacques (2014) Microbiota, oral microbiome, and pancreatic cancer. Cancer J 20:203-6|
|Wardlaw, Sharon L; Burant, Charles F; Klein, Samuel et al. (2014) Continuous 24-hour leptin, proopiomelanocortin, and amino acid measurements in human cerebrospinal fluid: correlations with plasma leptin, soluble leptin receptor, and amino acid levels. J Clin Endocrinol Metab 99:2540-8|
|Evans, Charles R; Karnovsky, Alla; Kovach, Melissa A et al. (2014) Untargeted LC-MS metabolomics of bronchoalveolar lavage fluid differentiates acute respiratory distress syndrome from health. J Proteome Res 13:640-9|
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