The proposed Michigan Regional Comprehensive Metabolomics Resource Core (MRCMRC or MRC2) is a fully integrated program that will provide researchers nation-wide with the expertise and infrastructure to determine the levels of known and unknown metabolites in cells, tissues and biological fluids. In addition, the MRC will provide opportunities for training in the technology of metabolomic analysis, statistical analysis and bioinformatic evaluation of metabolite data as well as approaches to Incorporation of metabolomics into basic, preclinical, translational and clinical research. Incorporated into this service component will be a robust research component directed towards improving the breadth of metabolite detection, the quality and efficiency of metabolomic analysis and importantly, tools to turn spectral data into knowledge to for the researcher The MRC2 will contain an Administrative Core to oversee and integrate operations;an Analytical Core to help design experiments for directed quantitative measure of metabolites or high-throughput evaluation of large numbers of known and unknown metabolites;a Data and Information Technology Core which will perform primary data processing or re-mining of archival data and will serve as a data repository;a Statistics and Bioinformatics Core which will assist researchers in the statistical evaluation of metabolomic data and integration with other 'omics or phenotypic data;and a Promotion and Outreach Core which will organize and provide seminars, symposia, workshops and web-based videos to increase the lay and research communities knowledge and use of metabolomic data.

Public Health Relevance

The RCMRC grant is directed towards providing increasing the technology to measure small molecules (metabolites) found in the body. These metabolites are the building blocks of all cells and participate in all body processes. By providing researchers with ways to measure the metabolites accurately from cells and tissues and in the blood, new insights into the ways In which changes in metabolism can contribute to diseases, such as diabetes and caner will be found. With this knowledge, new ways to prevent and treat a variety of diseases may be possible.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Resource-Related Research Projects--Cooperative Agreements (U24)
Project #
5U24DK097153-03
Application #
8730637
Study Section
Special Emphasis Panel (ZRG1)
Program Officer
Maruvada, Padma
Project Start
2012-09-04
Project End
2017-08-31
Budget Start
2014-09-01
Budget End
2015-08-31
Support Year
3
Fiscal Year
2014
Total Cost
Indirect Cost
Name
University of Michigan Ann Arbor
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
City
Ann Arbor
State
MI
Country
United States
Zip Code
48109
Sarkar, Mrinal K; Kaplan, Nihal; Tsoi, Lam C et al. (2017) Endogenous Glucocorticoid Deficiency in Psoriasis Promotes Inflammation and Abnormal Differentiation. J Invest Dermatol 137:1474-1483
Afshinnia, Farsad; Zeng, Lixia; Byun, Jaeman et al. (2017) Myeloperoxidase Levels and Its Product 3-Chlorotyrosine Predict Chronic Kidney Disease Severity and Associated Coronary Artery Disease. Am J Nephrol 46:73-81
Tavakoli, Sina; Short, John D; Downs, Kevin et al. (2017) Differential Regulation of Macrophage Glucose Metabolism by Macrophage Colony-stimulating Factor and Granulocyte-Macrophage Colony-stimulating Factor: Implications for (18)F FDG PET Imaging of Vessel Wall Inflammation. Radiology 283:87-97
Perng, Wei; Hector, Emily C; Song, Peter X K et al. (2017) Metabolomic Determinants of Metabolic Risk in Mexican Adolescents. Obesity (Silver Spring) 25:1594-1602
Calvert, Andrea E; Chalastanis, Alexandra; Wu, Yongfei et al. (2017) Cancer-Associated IDH1 Promotes Growth and Resistance to Targeted Therapies in the Absence of Mutation. Cell Rep 19:1858-1873
Phannasil, Phatchariya; Ansari, Israr-Ul H; El Azzouny, Mahmoud et al. (2017) Mass spectrometry analysis shows the biosynthetic pathways supported by pyruvate carboxylase in highly invasive breast cancer cells. Biochim Biophys Acta 1863:537-551
Reising, Arved E; Godinho, Justin M; Jorgenson, James W et al. (2017) Bed morphological features associated with an optimal slurry concentration for reproducible preparation of efficient capillary ultrahigh pressure liquid chromatography columns. J Chromatogr A 1504:71-82
Djuric, Zora; Aslam, Muhammad Nadeem; Simon, Becky R et al. (2017) Effects of fish oil supplementation on prostaglandins in normal and tumor colon tissue: modulation by the lipogenic phenotype of colon tumors. J Nutr Biochem 46:90-99
Wahl, Daniel R; Dresser, Joseph; Wilder-Romans, Kari et al. (2017) Glioblastoma Therapy Can Be Augmented by Targeting IDH1-Mediated NADPH Biosynthesis. Cancer Res 77:960-970
Šlechtová, Tereza; Gilar, Martin; Kalíková, Kv?ta et al. (2017) Performance comparison of three trypsin columns used in liquid chromatography. J Chromatogr A 1490:126-132

Showing the most recent 10 out of 126 publications