The Promotion and Outreach Core (P/O Core) of the Michigan Regional Comprehensive Metabolomic Resource Core (MRC2) will promote adoption of metabolomics technology to augment biomedical research and increase utilization of national Regional Comprehensive Metabolomics Resource Cores (RCMRCs). The P/O Core will leverage the support of 3 outstanding programs at the University of Michigan and their associated infrastructure: the School of Education, the Outreach and Dissemination Core of the National Center for Integrative Biomedical Informatics and the Education Core of the Michigan Institute for Clinical and Human Research (MICHR) home to the university's Clinical Translational Sciences Award (CTSA). The P/O Core will continue successful programs currently offered by the Michigan Metabolomics and Obesity Center. In addition, the Core will develop a Metabolomics Seminar Series, featuring external and UM speakers, develop a yearly Metabolomics Immersion Workshop and support an Individualized Multi-Week Metabolomics Instruction Program (Visiting Scientist Program). To disseminate material to a wider audience, the P/O, through the MRC2 website will offer on-line metabolomics instruction, including video and podcasts of the symposium, seminar series and select segments of the immersion workshop, develop short YouTube? videos which will provide information on metabolomics methodology with demonstration of the use of the University of Michigan metabolomics LIMS system, statistical packages and bioinformatics tools. The Core will develop user-centered interface Metabolomics Online to facilitate finding statistical and bioinformatic tools for metabolomic inside UM and external sites, including the RCMRCs. The site will also support a Wiki for interaction among the RCMRC to facilitate interaction and exchange of ideas. The P/6 core will support training of Post-graduates in metabolomics technology and informatics. Finally, the Core will support a traditional Pilot and Feasibility Program and a novel 'Small Pilot and Feasibility Program'that is modeled on a successful UM program to provide,rapid assistance for researchers to access the MRC2 infrastructure.

Public Health Relevance

The development of metabolomics has increased interest in the use of the technology by a broad range of scientists. The increased use of the technology will lead to increased understanding of disease. By supporting a variety of educational and outreach programs, the Promotion and Outreach Core will allow a larger number of scientists to understand metabolomics to use the technology in their research programs.

Project Start
Project End
Budget Start
2014-09-01
Budget End
2015-08-31
Support Year
3
Fiscal Year
2014
Total Cost
Indirect Cost
Name
University of Michigan Ann Arbor
Department
Type
DUNS #
City
Ann Arbor
State
MI
Country
United States
Zip Code
48109
Wernisch, Stefanie; Pennathur, Subramaniam (2016) Evaluation of coverage, retention patterns, and selectivity of seven liquid chromatographic methods for metabolomics. Anal Bioanal Chem 408:6079-91
Demehri, Farokh R; Frykman, Philip K; Cheng, Zhi et al. (2016) Altered fecal short chain fatty acid composition in children with a history of Hirschsprung-associated enterocolitis. J Pediatr Surg 51:81-6
Nadeem Aslam, Muhammad; Bassis, Christine M; Zhang, Li et al. (2016) Calcium Reduces Liver Injury in Mice on a High-Fat Diet: Alterations in Microbial and Bile Acid Profiles. PLoS One 11:e0166178
Giorgetti, Elisa; Yu, Zhigang; Chua, Jason P et al. (2016) Rescue of Metabolic Alterations in AR113Q Skeletal Muscle by Peripheral Androgen Receptor Gene Silencing. Cell Rep 17:125-36
Moore, Stephanie; Hess, Stephanie; Jorgenson, James (2016) Characterization of an immobilized enzyme reactor for on-line protein digestion. J Chromatogr A 1476:1-8
Ma, Siming; Upneja, Akhil; Galecki, Andrzej et al. (2016) Cell culture-based profiling across mammals reveals DNA repair and metabolism as determinants of species longevity. Elife 5:
Wynn, Michelle L; Yates, Joel A; Evans, Charles R et al. (2016) RhoC GTPase Is a Potent Regulator of Glutamine Metabolism and N-Acetylaspartate Production in Inflammatory Breast Cancer Cells. J Biol Chem 291:13715-29
Kochen, Michael A; Chambers, Matthew C; Holman, Jay D et al. (2016) Greazy: Open-Source Software for Automated Phospholipid Tandem Mass Spectrometry Identification. Anal Chem 88:5733-41
Theriot, Casey M; Bowman, Alison A; Young, Vincent B (2016) Antibiotic-Induced Alterations of the Gut Microbiota Alter Secondary Bile Acid Production and Allow for Clostridium difficile Spore Germination and Outgrowth in the Large Intestine. mSphere 1:
Obi, Andrea T; Stringer, Kathleen A; Diaz, Jose A et al. (2016) 1D-¹H-nuclear magnetic resonance metabolomics reveals age-related changes in metabolites associated with experimental venous thrombosis. J Vasc Surg Venous Lymphat Disord 4:221-30

Showing the most recent 10 out of 97 publications