The Promotion and Outreach Core (P/O Core) of the Michigan Regional Comprehensive Metabolomic Resource Core (MRC2) will promote adoption of metabolomics technology to augment biomedical research and increase utilization of national Regional Comprehensive Metabolomics Resource Cores (RCMRCs). The P/O Core will leverage the support of 3 outstanding programs at the University of Michigan and their associated infrastructure: the School of Education, the Outreach and Dissemination Core of the National Center for Integrative Biomedical Informatics and the Education Core of the Michigan Institute for Clinical and Human Research (MICHR) home to the university's Clinical Translational Sciences Award (CTSA). The P/O Core will continue successful programs currently offered by the Michigan Metabolomics and Obesity Center. In addition, the Core will develop a Metabolomics Seminar Series, featuring external and UM speakers, develop a yearly Metabolomics Immersion Workshop and support an Individualized Multi-Week Metabolomics Instruction Program (Visiting Scientist Program). To disseminate material to a wider audience, the P/O, through the MRC2 website will offer on-line metabolomics instruction, including video and podcasts of the symposium, seminar series and select segments of the immersion workshop, develop short YouTube? videos which will provide information on metabolomics methodology with demonstration of the use of the University of Michigan metabolomics LIMS system, statistical packages and bioinformatics tools. The Core will develop user-centered interface Metabolomics Online to facilitate finding statistical and bioinformatic tools for metabolomic inside UM and external sites, including the RCMRCs. The site will also support a Wiki for interaction among the RCMRC to facilitate interaction and exchange of ideas. The P/6 core will support training of Post-graduates in metabolomics technology and informatics. Finally, the Core will support a traditional Pilot and Feasibility Program and a novel 'Small Pilot and Feasibility Program' that is modeled on a successful UM program to provide,rapid assistance for researchers to access the MRC2 infrastructure.

Public Health Relevance

The development of metabolomics has increased interest in the use of the technology by a broad range of scientists. The increased use of the technology will lead to increased understanding of disease. By supporting a variety of educational and outreach programs, the Promotion and Outreach Core will allow a larger number of scientists to understand metabolomics to use the technology in their research programs.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Resource-Related Research Projects--Cooperative Agreements (U24)
Project #
4U24DK097153-05
Application #
9132220
Study Section
Special Emphasis Panel (ZRG1-BST-J)
Project Start
Project End
Budget Start
2016-09-01
Budget End
2017-08-31
Support Year
5
Fiscal Year
2016
Total Cost
$362,951
Indirect Cost
$129,542
Name
University of Michigan Ann Arbor
Department
Type
DUNS #
073133571
City
Ann Arbor
State
MI
Country
United States
Zip Code
48109
Perng, Wei; Tang, Lu; Song, Peter X K et al. (2018) Metabolomic profiles and development of metabolic risk during the pubertal transition: a prospective study in the ELEMENT Project. Pediatr Res :
Zarrinpar, Amir; Chaix, Amandine; Xu, Zhenjiang Z et al. (2018) Antibiotic-induced microbiome depletion alters metabolic homeostasis by affecting gut signaling and colonic metabolism. Nat Commun 9:2872
Ward, Kristen M; Yeoman, Larisa; McHugh, Cora et al. (2018) Atypical Antipsychotic Exposure May Not Differentiate Metabolic Phenotypes of Patients with Schizophrenia. Pharmacotherapy 38:638-650
Jadoon, Adil; Mathew, Anna V; Byun, Jaeman et al. (2018) Gut Microbial Product Predicts Cardiovascular Risk in Chronic Kidney Disease Patients. Am J Nephrol 48:269-277
Patel, Anita; Yusta, Bernardo; Matthews, Dianne et al. (2018) GLP-2 receptor signaling controls circulating bile acid levels but not glucose homeostasis in Gcgr-/- mice and is dispensable for the metabolic benefits ensuing after vertical sleeve gastrectomy. Mol Metab 16:45-54
Puskarich, Michael A; Evans, Charles R; Karnovsky, Alla et al. (2018) Septic Shock Nonsurvivors Have Persistently Elevated Acylcarnitines Following Carnitine Supplementation. Shock 49:412-419
Schofield, Heather K; Zeller, Jörg; Espinoza, Carlos et al. (2018) Mutant p53R270H drives altered metabolism and increased invasion in pancreatic ductal adenocarcinoma. JCI Insight 3:
Gok, Emre; Alghanem, Fares; Moon, Ruth et al. (2018) Development of an Ex-Situ Limb Perfusion System for a Rodent Model. ASAIO J :
Bria, Carmen R M; Afshinnia, Farsad; Skelly, Patrick W et al. (2018) Asymmetrical flow field-flow fractionation for improved characterization of human plasma lipoproteins. Anal Bioanal Chem :
Maile, Michael D; Standiford, Theodore J; Engoren, Milo C et al. (2018) Associations of the plasma lipidome with mortality in the acute respiratory distress syndrome: a longitudinal cohort study. Respir Res 19:60

Showing the most recent 10 out of 139 publications