The Southeast Resource Center for Integrated Metabolomics (SECIM) integrates existing strengths to create a comprehensive resource for basic and clinical scientists to obtain state-of-the-art metabolomics data and analyses. The SECIM Administrative Core is directed by Prof Arthur Edison, who will provide oversight of the entire project. The SECIM Program Coordinator, Dr. Eric Milgram, will oversee day-to-day operations, manage and optimize the overall workflow, serve as the primary interface and point of contact with SECIM users, and provide technical assistance to the mass spectrometry technical cores 1 and 3. Dr. Milgram has 60% of his effort in this core and 40% in the Bioinformatics Core to provide a seamless interface between the SECIM user portal, pipeline, and analysis. The Administrative Core provides oversight to SECIM through the establishment of 3 standing committees: the SECIM-Executive Committee (SECIM-EC), the Internal Advisory Committee (lAC), and the External Advisory Committee (EAC). SECIM-EC is comprised of SECIM leadership and is responsible for operational and budgetary decisions. The lAC is comprised of faculty representatives from colleges or centers at UF who have a stake in SECIM and will provide input about services;this group also covers the vast majority of types of metabolomics applications, ranging from agriculture to basic science to clinical science. The EAC is comprised of international metabolomics experts who will advise on technical and strategic matters and challenge SECIM to constantly improve. The Administrative Core will also develop and implement a comprehensive business plan, designed to move SECIM into full cost recovery in years 6 and beyond. Alicia Turner is the SECIM Chief Business Development Officer, and she has developed a model that serves as the starting budget for SECIM. During the first 3 years of operation, Ms. Turner will improve the model as real user data are recorded and true costs determined. She will train a financial assistant, who will implement the model in a full cost recovery auxiliary in the CTSI in year 6.
The major goal of metabolomics is the measurement and characterization of metabolites from living organisms, including people. Small molecule metabolites are sensitive to disease, treatment, and many environmental factors, and they can be used as indicators of disease in diagnosis or as markers to assess the outcome of treatment.
|Ardente, A J; Garrett, T J; Wells, R S et al. (2016) A Targeted Metabolomics Assay to Measure Eight Purines in the Diet of Common Bottlenose Dolphins, Tursiops truncatus. J Chromatogr Sep Tech 7:|
|Chouinard, Christopher D; Wei, Michael S; Beekman, Christopher R et al. (2016) Ion Mobility in Clinical Analysis: Current Progress and Future Perspectives. Clin Chem 62:124-33|
|Patterson, Rainey E; Kalavalapalli, Srilaxmi; Williams, Caroline M et al. (2016) Lipotoxicity in steatohepatitis occurs despite an increase in tricarboxylic acid cycle activity. Am J Physiol Endocrinol Metab 310:E484-94|
|Qiu, Yunping; Moir, Robyn; Willis, Ian et al. (2016) Isotopic Ratio Outlier Analysis of the S. cerevisiae Metabolome Using Accurate Mass Gas Chromatography/Time-of-Flight Mass Spectrometry: A New Method for Discovery. Anal Chem 88:2747-54|
|Liu, Haiyan; Tayyari, Fariba; Edison, Arthur S et al. (2016) NMR-based metabolomics reveals urinary metabolome modifications in female Sprague-Dawley rats by cranberry procyanidins. J Nutr Biochem 34:136-45|
|Markley, John L; BrÃ¼schweiler, Rafael; Edison, Arthur S et al. (2016) The future of NMR-based metabolomics. Curr Opin Biotechnol 43:34-40|
|Koethe, John R; Jenkins, Cathy A; Petucci, Christopher et al. (2016) Superior Glucose Tolerance and Metabolomic Profiles, Independent of Adiposity, in HIV-Infected Women Compared With Men on Antiretroviral Therapy. Medicine (Baltimore) 95:e3634|
|Bingol, Kerem; Bruschweiler-Li, Lei; Li, Dawei et al. (2016) Emerging new strategies for successful metabolite identification in metabolomics. Bioanalysis 8:557-73|
|Zhang, Bo; Xie, Mouzhe; Bruschweiler-Li, Lei et al. (2016) Nanoparticle-Assisted Removal of Protein in Human Serum for Metabolomics Studies. Anal Chem 88:1003-7|
|Antharam, Vijay C; McEwen, Daniel C; Garrett, Timothy J et al. (2016) An Integrated Metabolomic and Microbiome Analysis Identified Specific Gut Microbiota Associated with Fecal Cholesterol and Coprostanol in Clostridium difficile Infection. PLoS One 11:e0148824|
Showing the most recent 10 out of 32 publications