In this NIH Metabolomics Common Fund center proposal for a Regional Comprehensive Metabolomics Resource Core (RCMRC), """"""""Resource Center for Stable Isotope-Resolved Metabolomics"""""""", we aim to continue and expand on our current, successful Center for Regulatory and Environmental Analytical Metabolomics (CREAM). The role of the Administrative Core is to provide overall administration, budgetary management, oversee analytical services (e.g. sample tracking, analysis status, and billing), and oversight for the other 4 Cores'operations. The Core PI list comprises the current directorship of CREAM, ensuring smooth personnel and management transition to the NIH RCMRC version of CREAM. This section describes both current and expanded operations with regards to administration of the proposed center, and to ensure complete operational and policy harmony with the Common Funds goals. The Administrative Core will be responsible for all aspects of service scheduling and recharges, financial management of the annually awarded Pilot and Feasibility projects, maintaining all budgets and cost reporting of Cores, organizing outreach workshops and symposia, as well as coordinating annual reports, regular meetings among the project personnel and all interaction?s with other RCMRC's, program wide Executive Committee, the Data Repository and Coordinating Center (DRCC), NIH Project Scientist &staff, and any other appropriate entities.
The specific aims of the Administrative Core are as follows: SA1. Establish the RCMRC-CREAM and evolve a tiered set of services for users. SA2. Coordinate with Clients and manage sample, analytical, and data workflow across all Cores. SA3. Provide administrative and budgetary oversight for the RCMRC-CREAM and across all Cores. SA4. Coordinate external efforts with other RCMRC facilities, the Executive Committee, NIH Project Scientists and staff, NIH Common Fund programs, and any other appropriate entities. SA5. Plan and implement transition to self-sustaining operations.

Public Health Relevance

The Administrative Core is necessary to operate this complex metabolomics center for accelerating systems biochemical understanding of human diseases, from which novel biomarkers and therapeutic targets for many critical health issues can be uncovered and translated into clinical development.

Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of Kentucky
United States
Zip Code
Lane, Andrew N; Tan, Julie; Wang, Yali et al. (2017) Probing the metabolic phenotype of breast cancer cells by multiple tracer stable isotope resolved metabolomics. Metab Eng 43:125-136
Wang, Qingding; Zhou, Yuning; Rychahou, Piotr et al. (2017) Ketogenesis contributes to intestinal cell differentiation. Cell Death Differ 24:458-468
Yang, Ye; Fan, Teresa W-M; Lane, Andrew N et al. (2017) Chloroformate derivatization for tracing the fate of Amino acids in cells and tissues by multiple stable isotope resolved metabolomics (mSIRM). Anal Chim Acta 976:63-73
Yao, Sen; Flight, Robert M; Rouchka, Eric C et al. (2017) Perspectives and expectations in structural bioinformatics of metalloproteins. Proteins 85:938-944
Yao, Sen; Flight, Robert M; Rouchka, Eric C et al. (2017) Aberrant coordination geometries discovered in the most abundant metalloproteins. Proteins 85:885-907
Lane, Andrew N; Fan, Teresa W-M (2017) NMR-based Stable Isotope Resolved Metabolomics in systems biochemistry. Arch Biochem Biophys 628:123-131
Matrka, Marie C; Watanabe, Miki; Muraleedharan, Ranjithmenon et al. (2017) Overexpression of the human DEK oncogene reprograms cellular metabolism and promotes glycolysis. PLoS One 12:e0177952
Qi, Zhen; Voit, Eberhard O (2017) Inference of cancer mechanisms through computational systems analysis. Mol Biosyst 13:489-497
Zhao, Jiangsha; Li, Jieran; Fan, Teresa W M et al. (2017) Glycolytic reprogramming through PCK2 regulates tumor initiation of prostate cancer cells. Oncotarget 8:83602-83618
Sun, Ramon C; Fan, Teresa W-M; Deng, Pan et al. (2017) Noninvasive liquid diet delivery of stable isotopes into mouse models for deep metabolic network tracing. Nat Commun 8:1646

Showing the most recent 10 out of 28 publications