The Mayo Clinic Comprehensive Metabolomics Research Core (MCCMRC) integrates mass spectrometry and NMR Spectroscopy to measure metabolite concentrations and their in vivo dynamics using state of the art Stable isotope techniques. In addition, we propose an outreach and education program which will support feasibility studies and provide education and training opportunities to investigators wishing to utilize these techniques. The MCCMRC will expand services over those currently provided to cater the increasing needs of investigators at a regional and national level. Our services include large scale and targeted metabolomic profiling and measurement of stable isotopes in multiple metabolites, in an integrated fashion that allows us to track changes in metabolite concentration and the underlying rates of appearance and disappearance. This will enable mapping of alterations in dynamic metabolic networking in physiology as well as in pathological states. Clinique features of our program include the use of stable isotopes in diabetes, aging, cardiovascular and lipid research as well as phospometabolomic and pharmacometabolomic approaches. The program is integrated with the Proteomic, Genomic and Pharmacogenomic centers and is supported by a common Bioinformatics/biostatistics core. In addition, we are integrated closely to the major translational research programs in Mayo Clinic including the Centers of Individualized Medicine, Regenerative Medicine, Cancer, Alzheimer, Microbiome and Aging as well as the CTSA. This allows rapid translation of the findings to clinical practice thereby improving human health and patient care. The application offers an opportunity to develop networks with other national centers offering translational approaches to metabolomic technology. We will offer analytical services as well as expertise on study design, mathematical modeling, sample collection and data analysis to institutional, regional and national investigators. MCCMRC will expand our ability to offer a visiting scientists program of workshops, short-term training and didactic courses in order to educate them on the potential of metabolomics tools for research but also on the application of these techniques to their research protocols. In addition, we will leverage institutional training and career development and develop a curriculum and hands-on training program centered on metabolic training in the participating institutions. We will also offer pilot and feasibility funds to pursue innovative approaches to research based on metabolomics. The MCCMRC has an administrative core that will coordinate and integrate all activities of the education, training and feasibility program as well as the technology cores.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Resource-Related Research Projects--Cooperative Agreements (U24)
Project #
5U24DK100469-02
Application #
8731885
Study Section
Special Emphasis Panel (ZRG1)
Program Officer
Maruvada, Padma
Project Start
2013-09-10
Project End
2018-08-31
Budget Start
2014-09-01
Budget End
2015-08-31
Support Year
2
Fiscal Year
2014
Total Cost
Indirect Cost
Name
Mayo Clinic, Rochester
Department
Type
DUNS #
City
Rochester
State
MN
Country
United States
Zip Code
55905
Hinton, David J; Vázquez, Marely Santiago; Geske, Jennifer R et al. (2017) Metabolomics biomarkers to predict acamprosate treatment response in alcohol-dependent subjects. Sci Rep 7:2496
Talbert, Erin E; Yang, Jennifer; Mace, Thomas A et al. (2017) Dual Inhibition of MEK and PI3K/Akt Rescues Cancer Cachexia through both Tumor-Extrinsic and -Intrinsic Activities. Mol Cancer Ther 16:344-356
Zhang, Yuwen; Rao, Enyu; Zeng, Jun et al. (2017) Adipose Fatty Acid Binding Protein Promotes Saturated Fatty Acid-Induced Macrophage Cell Death through Enhancing Ceramide Production. J Immunol 198:798-807
Robinson, Matthew M; Dasari, Surendra; Konopka, Adam R et al. (2017) Enhanced Protein Translation Underlies Improved Metabolic and Physical Adaptations to Different Exercise Training Modes in Young and Old Humans. Cell Metab 25:581-592
Kazak, Lawrence; Chouchani, Edward T; Lu, Gina Z et al. (2017) Genetic Depletion of Adipocyte Creatine Metabolism Inhibits Diet-Induced Thermogenesis and Drives Obesity. Cell Metab 26:660-671.e3
Chang, Alice Y; Lalia, Antigoni Z; Jenkins, Gregory D et al. (2017) Combining a nontargeted and targeted metabolomics approach to identify metabolic pathways significantly altered in polycystic ovary syndrome. Metabolism 71:52-63
Lalia, Antigoni Z; Dasari, Surendra; Robinson, Matthew M et al. (2017) Influence of omega-3 fatty acids on skeletal muscle protein metabolism and mitochondrial bioenergetics in older adults. Aging (Albany NY) 9:1096-1129
Hames, Kazanna C; Morgan-Bathke, Maria; Harteneck, Debra A et al. (2017) Very-long-chain ?-3 fatty acid supplements and adipose tissue functions: a randomized controlled trial. Am J Clin Nutr 105:1552-1558
Hinshaw, Ling; Schiavon, Michele; Dadlani, Vikash et al. (2016) Effect of Pramlintide on Postprandial Glucose Fluxes in Type 1 Diabetes. J Clin Endocrinol Metab 101:1954-62
Vella, Adrian; Jensen, Michael D; Nair, K Sreekumaran (2016) Eulogy for the Metabolic Clinical Investigator? Diabetes 65:2821-3

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