Cardiac safety remains a major public health concern. Sudden cardiac death (SCD) for instance, is responsible for half of all heart disease deaths and is the largest cause of natural death in the U.S. (representing about 325,000 adults each year). Despite the effort implemented to reduce this number by early advanced care, there is a clear need for the improvement of risk stratification techniques to optimize the use of prophylactic therapies such as implantable defibrillators and drug therapies. Meanwhile cardiac safety is also one of the most challenging hurdles in the development of new molecular entities. It has been estimated that as many as 86% of all drugs tested in pharmaceutical development show specific inhibitory activity of potassium ion kinetics which in some cases can lead to torsades de pointes and potentially to SCD. According to the US Food and Drug Administration (FDA), the main reason for the inability of the current pharmaceutical to effectively screen out potentially harmful drugs is the lack of better markers to improve predictability and efficacy of new compounds. The roles of the surface electrocardiograms (ECGs) as a noninvasive approach to assess drug cardiotoxicity, to predict arrhythmic events, and to risk stratify cardiac and non-cardiac patients represent a matter of paramount importance. We propose to the NHLBI to enable the creation of a """"""""Center for Quantitative Electrocardiography and Cardiac Safety"""""""" (CES) by supporting its inceptive activities around 1) the development and maintenance of computer resources (data storage and computing center), 2) the deployment of medical information and 3) the formation of a scientific network. The CES will host the Telemetric and Holter ECG Warehouse, an initiative currently implemented by a working group consisting of staff members from the FDA, the University of Rochester and its Medical Center. The CES will distribute these resources to the International scientific community, sharing unique clinical and ECG information for the design and validation of technologies to improve quantitative electrocardiography and cardiac safety.

National Institute of Health (NIH)
National Heart, Lung, and Blood Institute (NHLBI)
Resource-Related Research Projects--Cooperative Agreements (U24)
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Special Emphasis Panel (ZHL1-CSR-U (M1))
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Boineau, Robin
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University of Rochester
Internal Medicine/Medicine
Schools of Dentistry
United States
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Couderc, Jean-Philippe; Ma, Shiyang; Page, Alex et al. (2017) An evaluation of multiple algorithms for the measurement of the heart rate corrected JTpeak interval. J Electrocardiol 50:769-775
Page, Alex; Aktas, Mehmet K; Soyata, Tolga et al. (2016) ""QT clock"" to improve detection of QT prolongation in long QT syndrome patients. Heart Rhythm 13:190-8
Tereshchenko, Larisa G; Cygankiewicz, Iwona; McNitt, Scott et al. (2012) Predictive value of beat-to-beat QT variability index across the continuum of left ventricular dysfunction: competing risks of noncardiac or cardiovascular death and sudden or nonsudden cardiac death. Circ Arrhythm Electrophysiol 5:719-27
Halamek, Josef; Couderc, Jean-Philippe; Jurak, Pavel et al. (2012) Measure of the QT-RR dynamic coupling in patients with the long QT syndrome. Ann Noninvasive Electrocardiol 17:323-30
Couderc, Jean-Philippe (2012) The Telemetric and Holter ECG Warehouse (THEW): the first three years of development and research. J Electrocardiol 45:677-83
Couderc, Jean-Philippe (2010) The telemetric and Holter ECG warehouse initiative (THEW): a data repository for the design, implementation and validation of ECG-related technologies. Conf Proc IEEE Eng Med Biol Soc 2010:6252-5
Baas, T; Gravenhorst, F; Fischer, R et al. (2010) Comparison of three T-Wave Delineation Algorithms based on Wavelet Filterbank, Correlation and PCA. Comput Cardiol (2010) 37:264-364
Burattini, Laura; Zareba, Wojciech; Burattini, Roberto (2010) Identification of gender-related normality regions for T-wave alternans. Ann Noninvasive Electrocardiol 15:328-36
Jie, Xiao; Rodriguez, Blanca; Pueyo, Esther (2010) A new ECG biomarker for drug toxicity: a combined signal processing and computational modeling study. Conf Proc IEEE Eng Med Biol Soc 2010:2565-8
Halámek, Josef; Jurák, Pavel; Lipoldová, Jolana et al. (2010) QT/RR Coupling and Gender Differences. Comput Cardiol (2010) 37:365-368

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